A5035218225- MicroRNA in disease regulation
- Natural product bioactivities and synthesis
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Chromatography in Natural Products
- Developmental Biology and Gene Regulation
- TGF-β signaling in diseases
- Pain Mechanisms and Treatments
- Bioactive Compounds and Antitumor Agents
- Sesquiterpenes and Asteraceae Studies
- Glycosylation and Glycoproteins Research
- Phytochemistry and Biological Activities
- Phytochemical Studies and Bioactivities
- Cell Adhesion Molecules Research
- Cancer-related gene regulation
- RNA Research and Splicing
- Histone Deacetylase Inhibitors Research
- Medicinal Plant Pharmacodynamics Research
- Axon Guidance and Neuronal Signaling
- Lung Cancer Treatments and Mutations
- Angiogenesis and VEGF in Cancer
- Phytochemical compounds biological activities
- Head and Neck Cancer Studies
- Kruppel-like factors research
University of Shanghai for Science and Technology
2025
Sichuan University
2025
Xi'an Chest Hospital
2024
Central South University
2023
Xiangya Hospital Central South University
2023
Eye & ENT Hospital of Fudan University
2017
82th Hospital of Pla
2016
Fudan University
2014
Air Force Medical University
2004-2014
Xijing Hospital
2012-2013
MiR-34a, a direct target of p53, has been shown to several molecules associated with the cell cycle and survival pathways, its dysregulation is implicated in cancer drug resistance or sensitivity human cancers. However, correlation between miR-34a expression chemoresistance not explored HCC. In this study, we confirmed that was significantly down-regulated HCC tissues lines by qRT-PCR. lower displayed higher Bcl-2 protein than those high miR-34a; therefore, an inverse evident level...
MicroRNA-10b (miR-10b) was recently reported to be dysregulated in some types of cancer and play a role invasion metastasis. However, effects potential mechanisms action miR-10b the metastasis hepatocellular carcinoma (HCC) have not been explored. In this study, we confirmed that is highly expressed metastatic HCC tissues cell lines by qRT-PCR. Moreover, patients with higher expression had significantly poorer overall survival, high an independent predictor poor prognosis. Inhibition reduced...
Due to invasion and intrahepatic metastasis, the prognosis for patients with hepatocellular carcinoma (HCC) is poor. However, mechanisms underlying these processes of HCC remain unclear. Cancer stem cells may be involved in early systemic dissemination metastasis formation side population (SP) isolated from diverse cancer possess cell-like properties. migration are not well understood. In this study, we identified populations SP cell lines using flow cytometry. showed higher levels...
Hepatocellular carcinoma (HCC) is one of the most common malignant tumours and it carries a poor prognosis due to high rate recurrence or metastasis after surgery. Bmi-1 plays significant role in growth many solid tumours. However, exact mechanisms underlying Bmi-1-mediated cell invasion metastasis, especially HCC, are not yet known. In present study, we sought evaluate expression HCC samples its relationship with clinicopathological characteristics prognostic value, also investigated...
Dysregulation of transcription factors (TFs) is associated with tumor progression, but little known about TF expression patterns in the context gastric cancer (GC) metastasis. Using array-based profile analysis, we found that 22 TFs showed differential activities between GC cell lines low- and high-metastatic potential. Of this group TFs, serum response factor (SRF) was significantly upregulated metastatic cells. SRF frequently elevated a panel cells tissues, high-level more aggressive...
Background The prognosis for patients with hepatocellular carcinoma (HCC) is poor, and the mechanisms underlying development of HCC remain unclear. Notch1 Notch3 may be involved in malignant transformation, although their roles unknown. Materials Methods tissues were stained anti-Notch1 or -Notch3 antibody. migration invasion capacities cells measured transwell cell culture chambers. RT-PCR was used to measure expression mRNA. Additionally, western blot analysis assess protein Notch1,...
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal solid tumor due to the lack of reliable early detection markers and effective therapies.MicroRNAs (miRNAs), noncoding RNAs that regulate gene expression, are involved in tumorigenesis have remarkable potential for diagnosis treatment malignancy.In this study, we investigated aberrantly expressed miRNAs PDAC by comparing miRNA expression profiles cell lines with normal pancreas line found miR-135a was significantly down-regulated...
MicroRNA-150 (miR-150) is frequently dysregulated in cancer and involved carcinogenesis progression. In this study, we found that miR-150 was significantly downregulated hepatocellular carcinoma (HCC) tissues compared to adjacent noncancerous tissues. Low levels of were associated with worse clinicopathological characteristics a poor prognosis for patients HCC. overexpression inhibited cell proliferation, migration invasion vitro tumor growth metastasis vivo. Further experiments indicated...
Hepatocellular carcinoma (HCC) is one of the most common human malignancies and also leading cause cancer-related death in world. The mechanisms underlying progression metastasis HCC remain unclear. E3 ubiquitin ligase F-box WD repeat domain-containing 7 (Fbxw7) broadly considered as a tumor suppressor gene. However, role Fbxw7 not clear. To investigate expression biological functions HCC, we examined level using tissue microarray immunohistochemistry. Our data showed that significantly...
Background: Lenvatinib is an oral tyrosine kinase inhibitor that selectively inhib-its receptors involved in tumor angiogenesis and growth. It emerging first-line treatment agent for hepatocellular carcinoma (HCC). However, there no intravenous ad-ministration of Lenvatinib. Aims: This study aimed to construct nanocomposites can efficiently support target liver cancer tissues cells. Objective: In this study, ferric oxide-viral-like mesoporous silica nanoparticles-folic acid (Fe3O4-vMSN-FA)...
ABSTRACT Prostate cancer (PCa) is one of the malignant tumors affecting men and an important reason for increase in male mortality worldwide. The pathogenesis PCa not fully understood. Thus, there urgent need to discover novel therapeutic targets facilitate development effective anti‐PCa strategies. Quantitative real‐time PCR Western blot were applied detect PODXL2 expressions tissues cells. Progression‐free survival patients was assessed using Kaplan–Meier analysis. relevance between...
Abstract Lung cancer continues to be the leading cause of cancer‐related mortality worldwide. This warrants search for new and effective agents against lung cancer. We others have recently shown that lanostane‐type triterpenoids isolated from fungal species Poria cocos ( P. ) can inhibit growth. However, mechanisms responsible anticancer effects these remain unclear. In this study, we investigated effect polyporenic acid C (PPAC), a triterpenoid , on growth A549 nonsmall cell cells (NSCLC)....
The objective of this study was to evaluate the potential using polymeric micelles modified with a peptide (termed GE11) ligand epidermal growth factor receptor as targeted carriers achieve increased accumulation in laryngeal cancer and enhanced intracellular delivery for encapsulated anticancer drugs. Poly (ethylene glycol)-distearoylphosphatidylethanolamine (PEG-DSPE) containing paclitaxel were prepared via film-hydration method followed by investigation vitro release phosphate-buffered...
Chemical investigation on the rhizome of Souliea vaginata resulted in isolation two new cycloartane triterpene glycosides and a alkaloid, soulieosides D E, soulieotine (1⎯3), their structures were elucidated basis extensive NMR spectral experiments chemical methods as (20S * ,22R ,23S ,24R )-16β:23;22:25-diepoxy-3β,24-dihydroxy-23-methoxy-9,19cyclolanostane-3-O-β-D-(4-acetyl)xylopyranoside (1), )-16β:23;22:25-diepoxy-3β,23,24-trihydroxy-9,19-cyclolanostane-3-O-β-D-(3-acet yl)xylopyranoside (2), E-3-
Six new acylated flavone C-glycosides, 2' '-O-(2' ''-methylbutyryl)isoswertisin (1), 3' (2), ''-methylbutyryl)vitexin (3), ''-methylbutyryl)orientin (4), '-O-(3' '',4' ''-dimethoxybenzoyl)vitexin (5), and ''-dimethoxybenzoyl)orientin (6), the known C-glycoside, isoswertisin, were isolated from flowers of Trollius ledebouri. The structures 1−6 elucidated by spectroscopic methods.
Medicinal plant is a main source of cancer drug development. Some the cycloartane triterpenoids isolated from aerial part Cimicifuga dahurica showed cytotoxicity in several cell lines. It great interest to examine antiproliferative activity and mechanisms total triterpenoid glycosides C. therefore might eventually be useful prevention or treatment Hepatoma.The (TGA) was extracted its evaluated HepG2 cells primary cultured normal mouse hepatocytes by an MTT assay. Morphology observation,...