A5026021847- Pituitary Gland Disorders and Treatments
- Adrenal and Paraganglionic Tumors
- Glioma Diagnosis and Treatment
- Growth Hormone and Insulin-like Growth Factors
- Neuroendocrine Tumor Research Advances
- Adrenal Hormones and Disorders
- Cancer, Hypoxia, and Metabolism
- Neuroblastoma Research and Treatments
- Head and Neck Surgical Oncology
- Meningioma and schwannoma management
- Diet, Metabolism, and Disease
- Hormonal Regulation and Hypertension
- Lung Cancer Research Studies
- Liver Disease Diagnosis and Treatment
- Estrogen and related hormone effects
- Nuclear Receptors and Signaling
- Cerebrospinal fluid and hydrocephalus
- Angiogenesis and VEGF in Cancer
- Peroxisome Proliferator-Activated Receptors
- Sinusitis and nasal conditions
- Diet and metabolism studies
- Cancer, Lipids, and Metabolism
- Retinoids in leukemia and cellular processes
- Neurofibromatosis and Schwannoma Cases
- Pancreatic function and diabetes
University of California, Los Angeles
2016-2025
UCLA Medical Center
2016-2025
University of California System
2025
Olive View-UCLA Medical Center
2021-2024
UCLA Health
2007-2022
University of Colorado Denver
2021
University of Colorado Cancer Center
2021
UCLA Jonsson Comprehensive Cancer Center
2021
University of Padua
2018
University of Iowa
2017
The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Neuroendocrine and Adrenal Gland Tumors focus on the diagnosis, treatment, management of patients with neuroendocrine tumors (NETs), adrenal tumors, pheochromocytomas, paragangliomas, multiple endocrine neoplasia. NETs are generally subclassified by site origin, stage, histologic characteristics. Appropriate diagnosis treatment often involves collaboration between specialists disciplines, using specific biochemical,...
We recently cloned a novel pituitary tumor transforming gene (PTTG). Here we report PTTG expression in human adenomas and normal tissue. In situ hybridization revealed nonfunctioning GH-secreting but not Using more sensitive detection method, RT-PCR, low level was detected pituitary. However, when levels tissue were compared with those 54 tumors using comparative reverse transcription polymerase chain reaction (RT-PCR), found that most samples expressed higher of PTTG. More than 50%...
Abstract Objective The aim of the Acromegaly Consensus Group was to revise and update consensus on diagnosis treatment acromegaly comorbidities last published in 2013. Participants Group, convened by 11 Steering Committee members, consisted 45 experts medical surgical management acromegaly. authors received no corporate funding or remuneration. Evidence This evidence-based developed using Grading Recommendations, Assessment, Development, Evaluation (GRADE) system describe both strength...
Somatostatin receptor (SSTR) PET has demonstrated a significant improvement over conventional imaging (CI) in patients with neuroendocrine tumors (NETs). SSTR should replace 111In-pentetreotide scintigraphy (OctreoScan; Mallinckrodt) all indications which the latter is currently being used
To collect outcome data in a large cohort of patients with aggressive pituitary tumours (APT)/carcinomas (PC) and specifically report effects temozolomide (TMZ) treatment.Electronic survey to ESE members Dec 2015-Nov 2016.Reports on 166 (40 PC, 125 APT, 1 unclassified) were obtained. Median age at diagnosis was 43 (range 4-79) years. 69% the clinically functioning, most frequent immunohistochemical subtype corticotroph (45%). Ki-67 index did not distinguish APT from median 7% 10%...
Abstract We report a covalent chemistry-based hepatocellular carcinoma (HCC)-specific extracellular vesicle (EV) purification system for early detection of HCC by performing digital scoring on the purified EVs. Earlier creates more opportunities curative therapeutic interventions. EVs are present in circulation at relatively stages disease, providing potential detection. develop an EV (i.e., Click Chips) synergistically integrating chemistry-mediated capture/release, multimarker antibody...
Pituitary tumorigenesis is a poorly understood process involving dysregulation of the cell cycle, proliferation, and angiogenesis. The novel securin pituitary tumor transforming gene (PTTG) disrupts division stimulates fibroblast growth factor (FGF)-2-mediated We investigated expression angiogenic vascular endothelial (VEGF) its receptor KDR/Flk-1 in 103 human tumors, we assessed functional relationships between these genes vitro. Nonfunctioning tumors (n = 81) demonstrated markedly raised...
Carbohydrate metabolism via glycolysis and the tricarboxylic acid cycle is pivotal for cancer growth, increased refined carbohydrate consumption adversely affects survival. Traditionally, glucose fructose have been considered as interchangeable monosaccharide substrates that are similarly metabolized, little attention has given to sugars other than glucose. However, intake dramatically in recent decades cellular uptake of uses distinct transporters. Here, we report provides an alternative...
Abstract Context Cushing disease, a chronic hypercortisolism disorder, is associated with considerable morbidity and mortality. Normalizing cortisol production the primary treatment goal. Objective We aimed to evaluate safety efficacy of osilodrostat, potent, orally available 11βhydroxylase inhibitor, compared placebo in patients disease. Methods LINC 4 was phase III, multicenter trial comprising an initial 12-week, randomized, double-blind, placebo-controlled (osilodrostat:placebo, 2:1)...
Pituitary hyperplasia and lactotroph replication are induced by estrogen. The product of the pituitary tumor transforming gene (PTTG) exhibits in vitro vivo activity induces basic bFGF secretion, thereby modulating angiogenesis formation. We demonstrated previously that pttg is estrogen bFGF, latter being expressed a concordant fashion with experimental human adenomas. now elucidate role paracrine regulation tumorigenesis PTTG. Coincident circulating rat estradiol surge maximal...
Pituitary tumors cause considerable morbidity due to local invasion, hypopituitarism, or hormone hypersecretion. In many cases, no suitable drug therapies are available, and surgical excision is currently the only effective treatment. We show here abundant expression of nuclear receptor PPAR-γ in all 39 human pituitary tumors. activating thiazolidinediones (TZDs) rosiglitazone troglitazone induced G0-G1 cell-cycle arrest apoptosis human, rat somatolactotroph, murine gonadotroph tumor cells,...
Summary objective Pituitary tumour transforming gene (PTTG) encodes a multifunctional protein that is implicated in initiating and perpetuating pituitary adenoma growth. PTTG appears to have key regulatory functions determining control of many fundamental cellular events including mitosis, cell transformation, DNA repair regulation. Several these are mediated through interactions with binding factor (PBF) fibroblast growth factor‐2 (FGF‐2). Given this background, we determined the expression...
Pituitary hyperplasia and lactotroph replication are induced by estrogen. The product of the pituitary tumor transforming gene (PTTG) exhibits in vitro vivo activity induces basic bFGF secretion, thereby modulating angiogenesis formation. We demonstrated previously that pttg is estrogen bFGF, latter being expressed a concordant fashion with experimental human adenomas. now elucidate role paracrine regulation tumorigenesis PTTG. Coincident circulating rat estradiol surge maximal...