A5021070209- Growth Hormone and Insulin-like Growth Factors
- Pituitary Gland Disorders and Treatments
- Adrenal Hormones and Disorders
- Adrenal and Paraganglionic Tumors
- Cancer, Hypoxia, and Metabolism
- Diabetes and associated disorders
- Liver Disease Diagnosis and Treatment
- Lipid metabolism and disorders
- Neuroendocrine Tumor Research Advances
- Regulation of Appetite and Obesity
- Adipose Tissue and Metabolism
- Metabolism, Diabetes, and Cancer
- Myasthenia Gravis and Thymoma
- Diet and metabolism studies
- Neuroblastoma Research and Treatments
- Cancer Immunotherapy and Biomarkers
- Hormonal Regulation and Hypertension
- Adipokines, Inflammation, and Metabolic Diseases
- Ion channel regulation and function
- Food Allergy and Anaphylaxis Research
- Birth, Development, and Health
- IgG4-Related and Inflammatory Diseases
- Biochemical Analysis and Sensing Techniques
- Thyroid Disorders and Treatments
- Muscle Physiology and Disorders
Kobe University
2016-2025
Nara Medical University
1990-2025
NTT Medical Center
2016-2024
Nara Medical University Hospital
2020-2024
Tokyo Medical and Dental University Hospital
2011-2022
Hamamatsu University School of Medicine
2021
Diabetes Australia
2013-2020
Tohoku Medical and Pharmaceutical University
2020
Kobe University Hospital
2015
Nagoya Institute of Technology
2014
To explore a novel adipokine, we screened adipocyte differentiation‐related gene and found that TIG2/chemerin was strongly induced during the differentiation. Chemerin secreted by mature 3T3‐L1 adipocytes expressed abundantly in adipose tissue vivo as recently described. Intriguingly, expression of chemerin differently regulated liver db / mice. In addition, serum concentration decreased its receptor/ChemR23 were adipocytes, suggesting function autocrine/paracrine fashion. Finally,...
Leptin, secreted by adipocytes, regulates satiety and energy expenditure. Several forms of leptin receptors produced alternative mRNA splicing are found in many tissues, including the hypothalamus, liver, lung, kidney, hematopoietic cells, gonads, suggesting that exerts effects these tissues. In accordance with distribution receptors, there is accumulating evidence plays various roles reproduction, hematopoiesis, immune systems addition to regulation food intake present study, we examined...
Liver dysfunction in adult hypopituitary patients with GH deficiency (GHD) has been reported and an increased prevalence of nonalcoholic fatty liver disease (NAFLD) suggested. The objective the present study was to elucidate pathophysiology GHD. We recruited 69 consecutive Japanese GHD examined NAFLD by ultrasonography steatohepatitis (NASH) biopsy. Patients had given routine replacement therapy except for GH. compared these healthy age-, gender-, BMI-matched controls. further analyzed...
Although various function of chemerin have been suggested, its physiological role remains to be elucidated. Here we show that chemerin-deficient mice are glucose intolerant irrespective exhibiting reduced macrophage accumulation in adipose tissue. The intolerance was mainly due increased hepatic production and impaired insulin secretion. Chemerin receptor ChemR23 were expressed β-cell. Studies using isolated islets perfused pancreas revealed glucose-dependent secretion (GSIS) mice....
Abstract Hepatic fibrosis in nonalcoholic steatohepatitis (NASH) and cirrhosis determines patient prognosis; however, effective treatment for has not been established. Oxidative stress inflammation activate hepatic stellate cells (HSCs) promote fibrosis. In contrast, cellular senescence inhibits HSCs’ activity limits The aim of this study was to explore the effect IGF-I on NASH cirrhotic models clarify underlying mechanisms. We demonstrate that significantly ameliorated steatosis,...
The causes of growth hormone–dependent short stature are primary pituitary disease, deficiency due to hypothalamic dysfunction, and, less often, insensitivity hormone. prototypical syndrome hormone is Laron-type dwarfism, which characterized by absent or defective receptors. Kowarski et al. described two children with retardation resulting from biologically inactive hormone1; additional cases were reported subsequently.2–7 This disorder high serum concentrations immunoreactive hormone, low...
Most of the GH receptor (GHR) gene abnormalities causing insensitivity syndrome (GHIS) are located in region coding extracellular domain, and serum GH-binding protein (GHBP) levels, determined by ligand-mediated immunofunctional assay, low most patients with GHIS. We present here a heterozygous point mutation donor splice site intron 9 GHR two Japanese siblings GHIS, whose GHBP levels were high. The same was found their mother as well. analysis ribonucleic acid from peripheral leukocytes...
The pituitary-specific transcriptional factor-1 (PIT-1, also known as POU1F1), is an essential factor for multiple hormone-secreting cell types. A genetic defect in the PIT-1 gene results congenital growth hormone (GH), prolactin (PRL), and thyroid-stimulating (TSH) deficiency. Here, we investigated 3 cases of adult-onset combined GH, PRL, TSH deficiencies found that endocrinological phenotype each was linked to autoimmunity directed against protein. We detected anti-PIT-1 antibody along...
IGF-I induces skeletal muscle hypertrophy by stimulating protein synthesis and suppressing the degradation pathway; downstream signaling pathways Akt-mammalian target of rapamycin (mTOR)-p70-kDA-S6-kinase (p70S6K), Forkhead box O1 (FoxO1) play essential roles in this regulation. Reactive oxygen species (ROS) modulate various growth factors via redox However, role ROS is not fully understood. In study, we investigated whether regulate biological action C2C12 myocytes. We found that While...
Adaptation under fasting conditions is critical for survival in animals. Sirtuin 1 (SIRT1), a protein deacetylase, plays an essential role adaptive metabolic and endocrine responses by modifying the acetylation status of various proteins. Fasting induces growth hormone (GH) resistance liver, leading to decreased serum insulin-like factor-I (IGF-I) levels as adaptation malnutrition; however, underlying mechanisms this action remain be fully elucidated. Here we report that vivo knockdown SIRT1...
Pituitary develops from oral ectoderm in contact with adjacent ventral hypothalamus. Impairment this process results congenital pituitary hypoplasia (CPH); however, there have been no human disease models for CPH thus far, prohibiting the elucidation of underlying mechanisms. In study, we established a model using patient-derived induced pluripotent stem cells (iPSCs) and 3D organoid technique, which hypothalamus develop simultaneously. Interestingly, patient iPSCs heterozygous mutation...