A5022591078- Pituitary Gland Disorders and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Adrenal and Paraganglionic Tumors
- Adrenal Hormones and Disorders
- Hormonal Regulation and Hypertension
- Semiconductor materials and devices
- Semiconductor materials and interfaces
- Pluripotent Stem Cells Research
- Myasthenia Gravis and Thymoma
- Liver Disease Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- IgG4-Related and Inflammatory Diseases
- Neuroendocrine Tumor Research Advances
- Integrated Circuits and Semiconductor Failure Analysis
- Advancements in Semiconductor Devices and Circuit Design
- Neuroblastoma Research and Treatments
- Telomeres, Telomerase, and Senescence
- CRISPR and Genetic Engineering
- 3D Printing in Biomedical Research
- CCD and CMOS Imaging Sensors
- Lipid metabolism and disorders
- Liver physiology and pathology
- Single-cell and spatial transcriptomics
- Advanced Semiconductor Detectors and Materials
- Birth, Development, and Health
Kobe University
2013-2025
Kyoto University
2021-2025
Kobe University Hospital
2019-2022
Sony (Taiwan)
2006-2019
Diabetes Australia
2019
Hiroshima University
2008-2010
Rockwell Automation (United States)
1979
Abstract Hepatic fibrosis in nonalcoholic steatohepatitis (NASH) and cirrhosis determines patient prognosis; however, effective treatment for has not been established. Oxidative stress inflammation activate hepatic stellate cells (HSCs) promote fibrosis. In contrast, cellular senescence inhibits HSCs’ activity limits The aim of this study was to explore the effect IGF-I on NASH cirrhotic models clarify underlying mechanisms. We demonstrate that significantly ameliorated steatosis,...
The pituitary is a major hormone center that secretes systemic hormones responding to hypothalamus-derived-releasing hormones. Previously, we reported the independent induction and hypothalamic differentiation of human embryonic stem cells (ESCs). Here, functional hypothalamic-pituitary unit generated using induced pluripotent (iPS) in vitro. adrenocorticotropic (ACTH) secretion capacity reached comparable level adult mouse because simultaneous maturation with neurons within same aggregates....
Pituitary develops from oral ectoderm in contact with adjacent ventral hypothalamus. Impairment this process results congenital pituitary hypoplasia (CPH); however, there have been no human disease models for CPH thus far, prohibiting the elucidation of underlying mechanisms. In study, we established a model using patient-derived induced pluripotent stem cells (iPSCs) and 3D organoid technique, which hypothalamus develop simultaneously. Interestingly, patient iPSCs heterozygous mutation...
We developed a back-illuminated InGaAs image sensor with 1280x1040 pixels at 5-um pitch by using Cu-Cu hybridization connecting different materials, III-V InGaAs/InP of photodiode array (PDA), and silicon readout integrated circuit (ROIC). A new process architecture an dies-to-silicon wafer bonding was established for high productivity pixel-pitch scaling. achieved low dark current sensitivity wavelengths ranging from visible to short-wavelength infrared (SWIR).
Immune checkpoint inhibitors (ICIs) as a cancer immunotherapy have emerged treatment for multiple advanced types. Because of enhanced immune responses, immune-related adverse events (irAEs), including endocrinopathies such hypophysitis, been associated with the use ICIs. Most underlying mechanisms ICI-related hypophysitis remain unclear, especially programmed cell death-1 (PD-1)/PD-1 ligand 1 (PD-L1) inhibitors. We hypothesized that is paraneoplastic syndrome caused by ectopic expression...
Cancer immunotherapy has emerged as treatment of multiple advanced cancer types. Immune checkpoint inhibitors, namely anticytotoxic T-lymphocyte antigen-4 (CTLA-4), antiprogrammed cell death-1 (PD-1), and ligand 1 (PD-L1) antibodies, have been used for various cancers. Classified immune-related adverse events, several endocrinopathies, including hypophysitis, are associated with these agents. Although anti-CTLA-4-induced hypophysitis frequently observed, upon use anti-PD-1 anti-PD-L1...
Objective Patients with acromegaly exhibit reduced life expectancy and increased prevalence of age-related diseases, such as diabetes, hypertension, cardiovascular disease. However, the underlying mechanism has not been fully elucidated. Telomere shortening is reportedly associated these diseases. Methods We measured telomere length in patients using quantitative PCR method. The effect GH IGF-I on cellular senescence was examined human skin fibroblasts. Results exhibited shorter than age-,...
Anti-pituitary-specific transcriptional factor 1 (PIT-1) antibody syndrome is characterized by acquired growth hormone (GH), prolactin (PRL), and thyroid-stimulating (TSH) deficiencies associated with circulating anti-PIT-1 antibodies. Although autoimmunity to PIT-1 has been suggested as a pathogenesis, the precise mechanism of remains unclarified.To elucidate involvement antibody- or cell-mediated immunity in syndrome.To investigate direct effect on pituitary cells, cell proliferation,...
Most of acromegaly is caused by a sporadic somatotropinoma and couple novel gene mutations responsible for have recently been reported. To determine the cause in Japanese patients, we analyzed 61 consecutive patients with without apparent family history. Comprehensive genetic analysis revealed that 31 harbored guanine nucleotide-binding protein, alpha stimulating (GNAS) (50.8%) three aryl hydrocarbon receptor interacting protein (AIP) (4.9%). No had G protein-coupled 101 (GPR101) mutations....
Abstract Context Anti–pituitary-specific transcriptional factor-1 (anti–PIT-1) antibody syndrome is characterized by acquired and specific deficiencies in growth hormone, prolactin, thyroid-stimulating hormone. Although PIT-1–reactive cytotoxic T lymphocytes (CTLs) have been speculated to recognize anterior pituitary cells cause the injury pathogenesis of syndrome, it remains unclear whether endogenous PIT-1 protein processed through proteolytic pathway presented as an antigen on cells....
Although acromegaly has been reported in patients with Neurofibromatosis type 1 (NF1), these cases have not associated growth hormone (GH)-producing somatotroph adenoma, but optic pathway glioma.A 68 year-old Japanese woman, who had clinically diagnosed NF1, was referred to our hospital due a thyroid tumor and hypercalcemia.Acromegaly suspected her facial features, subsequent examinations revealed the presence of GH excess pituitary tumor, leading diagnosis acromegaly.Histological...
Heterogeneous clinical characteristics are observed in acquired isolated adrenocorticotropic hormone (ACTH) deficiency (IAD); however, its classification remains to be established because of largely unknown pathophysiology. In IAD, anti-pituitary antibodies have been detected some patients, although their significance unclear. Therefore, this study aimed classify patients with IAD and clarify the antibodies. We analyzed 46 consecutive IAD. Serum were via immunofluorescence staining using a...
Accumulating evidence suggests that cellular heterogeneity in organs and cell-cell tissue-tissue interactions are crucial for maintaining physical homeostasis disease progression. Endocrine also exhibit comprise multiple cell types. For instance, the pituitary gland comprises five types of hormone-producing cells as well non-hormone-producing supporting cells, such fibroblasts, endothelial folliculostellate cells. However, functional roles between non-producing remain incompletely...
CMOS technologies using metal/high-k damascene gate stacks with uniaxial strained silicon channels were developed. Gate electrodes of HfSix and TiN applied to nFETs pFETs, respectively. TiN/HfO2 epitaxial SiGe source/drains successfully integrated for the first time. As a result, drive currents 1050 710 uA/um at Vdd=1 V, Ioff= 100 nA/um Tinv=1.6 nm obtained pFETs. The further integration pFETs on (110) substrates contributed higher current 830 uA/um. These performances realized under low...