A5101745399- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Parathyroid Disorders and Treatments
- Pancreatic and Hepatic Oncology Research
- Xenotransplantation and immune response
- Neuropeptides and Animal Physiology
- Genetic Syndromes and Imprinting
- Hepatocellular Carcinoma Treatment and Prognosis
- Renal Transplantation Outcomes and Treatments
- Pain Mechanisms and Treatments
- Neuroscience and Neuropharmacology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Neuroendocrine Tumor Research Advances
- Gastric Cancer Management and Outcomes
- Liver Disease Diagnosis and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Medical Imaging and Pathology Studies
- Pancreatic function and diabetes
- Traumatic Brain Injury and Neurovascular Disturbances
- Cancer Treatment and Pharmacology
- Organ Donation and Transplantation
- Glycosylation and Glycoproteins Research
- Virus-based gene therapy research
- Ovarian cancer diagnosis and treatment
- Colorectal Cancer Treatments and Studies
Nagoya University
2015-2025
Nagoya City University
1983-2025
Tokyo Women's Medical University Adachi Medical Center
2024-2025
Showa University Fujigaoka Hospital
2018-2024
RIKEN Center for Sustainable Resource Science
2018-2024
Menard (Poland)
2018-2023
University of the Ryukyus
2022
Diabetes Australia
2020
Neostem (United States)
2019-2020
Tohoku University
1991-2019
Immune checkpoint inhibitors, including anti–programmed cell death-1 (PD-1) antibodies, have become promising treatments for a variety of advanced malignancies. However, these medicines can cause immune-related adverse events (irAEs), endocrinopathies. This study examined the incidence endocrine irAEs induced by nivolumab. Sixty-six patients treated with nivolumab at Nagoya University Hospital were prospectively evaluated pituitary hormones, thyroid function, antithyroid antibodies (Abs),...
To elucidate the clinical significance of neural invasion in pancreatic carcinoma, a clinicopathological study was performed. Neural is common feature carcinoma whose has not yet been determined. Over period > 10 years, 129 204 (63%) patients with underwent resection by extensive radical surgery. A those specimens performed, particular reference to invasion. Intrapancreatic observed 116 (90%), which 80 (69%) showed extrapancreatic nerve plexus involvement. statistically significant (p <...
The ontogeny of the somatostatin (SRIF) neuron system in forebrain and diencephalon rat was investigated by means indirect immunofluorescence method. SRIF-positive cells first appear primordium hypothalamus surrounding fasciculus mammillothalamicus fetus at gestational day 14 (10-12-mm embryo). At days 16-17 (14-17-mm embryo, developing piriform cortex entopeduncular nucleus. 18-19 (17-26-mm embryos) showed a remarkable increase number numerous groups such are detectable various diencephalic...
The present study aimed to evaluate the effects of flash glucose monitoring (FGM) and conventional self-monitoring blood (SMBG) on glycemic control in patients with non-insulin-treated type 2 diabetes.In this 24-week, multicenter, open-label, randomized (1:1), parallel-group study, diabetes at five hospitals Japan were randomly assigned FGM (n=49) or SMBG (n=51) groups provided each device for 12 weeks. primary outcome was change glycated hemoglobin (HbA1c) level, compared using analysis...
Hyponatremia is the most common clinical electrolyte disorder. Once thought to be asymptomatic in response adaptation by brain, recent evidence suggests that chronic hyponatremia may linked attention deficits, gait disturbances, risk of falls, and cognitive impairments. Such neurologic defects are associated with a reduction quality life significant cause mortality. However, because underlying diseases such as adrenal insufficiency, heart failure, liver cirrhosis, cancer also affect brain...
Background Several immune-related adverse events (irAEs) are reported to be associated with therapeutic efficacy of immune checkpoint inhibitors, yet whether pituitary dysfunction, a life-threatening irAE, affects overall survival (OS) in patients malignancies is unclear. This prospective study examined the association dysfunction (pituitary-irAE) OS non-small cell lung carcinoma (NSCLC) or malignant melanoma (MM). Methods A total 174 (NSCLC, 108; MM, 66) treated ipilimumab, nivolumab,...
The pituitary is a major hormone center that secretes systemic hormones responding to hypothalamus-derived-releasing hormones. Previously, we reported the independent induction and hypothalamic differentiation of human embryonic stem cells (ESCs). Here, functional hypothalamic-pituitary unit generated using induced pluripotent (iPS) in vitro. adrenocorticotropic (ACTH) secretion capacity reached comparable level adult mouse because simultaneous maturation with neurons within same aggregates....
CD4 + T cells are essential for development of thyroiditis induced by anti–PD-1 antibody treatment in thyroglobulin-immunized mice.
Background Pituitary dysfunction is a life-threatening immune-related adverse event (irAE) induced by immune checkpoint inhibitors (ICIs). To date, it not possible to identify patients who may develop pituitary irAEs prior ICI treatment. The aim of this study was characterize the predisposition for ICI-induced analyzing anti-pituitary antibodies (APAs) and human leukocyte antigens (HLAs). Methods In case–control study, APAs HLA alleles were analyzed in 62 (17 developed isolated...
We investigated the effects of intraplantar (i.pl.) administration l ‐arginine and N G ‐nitro‐ methyl ester ( ‐NAME) on formalin‐induced behavioural nociception in mouse. ‐ but not d ‐arginine, at 0.1 − 1 μg per paw, coadministered with i.pl. formalin, enhanced second‐but first‐phase nociceptive responses, whereas it was without significant 3 conversely, produced antinociception 10 resulting a bell‐shaped dose‐response curve. ‐NAME when administered i.pl., exhibited antinociceptive activity...
The perpendicular anisotropy caused by the internal planar stress due to substrate constraint in Gd-Fe and Tb-Fe sputtered films was investigated. σ these is found be very sensitive preparation conditions, especially argon pressure during sputtering, PAr. Stress compressive for low PAr tensile high contribution of total varies depending on Measurement change before after removal reveals that predominant part originates from with a composition around 30 at.%Tb, where magnetostriction...
Central diabetes insipidus (CDI) can be caused by several diseases, but in about half of the patients etiological diagnosis remains unknown. Lymphocytic infundibulo-neurohypophysitis (LINH) is an increasingly recognized entity among cases idiopathic CDI; however, differential from other pituitary diseases including tumors difficult because similar clinical and radiological manifestations. The definite LINH requires invasive biopsy.The study was designed to identify autoantigen(s) thus...
Abstract Background Anti-programmed cell death-1 (PD-1) antibodies can cause thyroid dysfunction. However, no predictive biomarkers enabling stratification of dysfunction risk have been identified. Methods A total 209 patients treated with an anti-PD-1 antibody were evaluated for anti-thyroid at baseline and prospectively function every 6 weeks 24 after treatment initiation, then observed until the visits stopped. Thyroid ultrasonography was performed if patient positive baseline. Results Of...
During recent years the electrical phenomena associated with spinal reflex functions have been recorded by means of electrodes placed on ventral and dorsal roots or cord.The physiological significance these has determined to a certain extent neurophysiologists.More recently, Magoun his associates (1, 2, 3) found that. reticular formation brain stem descending inhibitory facilitatory influences upon activity.The electrophysiological study effect morphine reported Wikler (4), but its remains...