Timo Deutschbein
A5009989142- Pituitary Gland Disorders and Treatments
- Adrenal and Paraganglionic Tumors
- Hormonal Regulation and Hypertension
- Adrenal Hormones and Disorders
- Cancer, Hypoxia, and Metabolism
- Growth Hormone and Insulin-like Growth Factors
- Glioma Diagnosis and Treatment
- Stress Responses and Cortisol
- Myasthenia Gravis and Thymoma
- Neuroblastoma Research and Treatments
- Ophthalmology and Eye Disorders
- Meningioma and schwannoma management
- Cancer, Lipids, and Metabolism
- Hormonal and reproductive studies
- Sexual Differentiation and Disorders
- Mitochondrial Function and Pathology
- Thyroid Cancer Diagnosis and Treatment
- Cardiovascular Function and Risk Factors
- Neuroendocrine Tumor Research Advances
- Electrolyte and hormonal disorders
- Neural Networks and Applications
- Heart Failure Treatment and Management
- Diabetes and associated disorders
- Graph Theory and Algorithms
- Metabolomics and Mass Spectrometry Studies
Universitätsklinikum Würzburg
2016-2025
University of Würzburg
2016-2025
Medicover
2020-2024
Klinikum Oldenburg
2021-2022
University of Padua
2018-2021
Klinik und Poliklinik für Neurologie
2013-2021
Center for HIV and Hepatogastroenterology
2021
Azienda Ospedaliera di Padova
2021
Walter de Gruyter (Germany)
2021
European Neuroendocrine Tumor Society
2012-2020
Recurrence of adrenocortical carcinoma (ACC) even after complete (R0) resection occurs frequently. The aim this study was to identify markers with prognostic value for patients in clinical setting. From the German ACC registry, 319 European Network Study Adrenal Tumors stage I–III were identified. As an independent validation cohort, 250 from three countries included. Clinical, histological, and immunohistochemical correlated recurrence-free (RFS) overall survival (OS). Although univariable...
To collect outcome data in a large cohort of patients with aggressive pituitary tumours (APT)/carcinomas (PC) and specifically report effects temozolomide (TMZ) treatment.Electronic survey to ESE members Dec 2015-Nov 2016.Reports on 166 (40 PC, 125 APT, 1 unclassified) were obtained. Median age at diagnosis was 43 (range 4-79) years. 69% the clinically functioning, most frequent immunohistochemical subtype corticotroph (45%). Ki-67 index did not distinguish APT from median 7% 10%...
Cross-sectional imaging regularly results in incidental discovery of adrenal tumours, requiring exclusion adrenocortical carcinoma (ACC). However, differentiation is hampered by poor specificity characteristics. We aimed to validate a urine steroid metabolomics approach, using profiling as the diagnostic basis for ACC.
Malignant pheochromocytoma and paraganglioma (MPP) are characterized by prognostic heterogeneity. Our objective was to look for parameters of overall survival (OS) in MPP patients. Retrospective multicenter study a neck-thoraco-abdomino-pelvic CT or MRI at the time malignancy diagnosis European centers between 1998 2010. One hundred sixty-nine patients from 18 were included. Main characteristics with were: primary 53% patients; tumor- hormone-related symptoms 57% 58% cases; positive plasma...
Background: Benign adrenal tumors are commonly discovered on cross-sectional imaging. Mild autonomous cortisol secretion (MACS) is regularly diagnosed, but its effect cardiometabolic disease in affected persons ill defined. Objective: To determine burden and steroid excretion with benign without MACS. Design: Cross-sectional study. Setting: 14 endocrine secondary tertiary care centers (recruitment from 2011 to 2016). Participants: 1305 prospectively recruited tumors. Measurements: Cortisol...
Adrenocortical carcinoma (ACC) is a rare malignancy that harbors dismal prognosis in advanced stages. Mitotane approved as an orphan drug for treatment of ACC and counteracts tumor growth steroid hormone production. Despite serious adverse effects, mitotane has been clinically used decades. Elucidation its unknown molecular mechanism action seems essential to develop better therapies. Here, we set out identify the target altered downstream mechanisms by combining expression genomics mass...
Abstract BACKGROUND Measurements of plasma or urinary metanephrines are recommended for diagnosis pheochromocytoma and paraganglioma (PPGL). What test offers optimal diagnostic accuracy patients at high low risk disease, whether free offer advantages over deconjugated metanephrines, what offered by including methoxytyramine in panels all remain unclear. METHODS A population 2056 with suspected PPGLs underwent prospective screening disease using mass spectrometric-based measurements free,...
Surgery is the standard of care for localized adrenocortical carcinomas, but its role recurrent disease not well defined.Our objective was to evaluate clinical outcome after surgery recurrence.We conducted a retrospective analysis in 154 patients with first recurrence initial radical resection from German Adrenocortical Carcinoma Registry.We evaluated progression-free survival (PFS) and overall (OS) by Kaplan-Meier method identified prognostic factors Cox regression analysis.A total 101...
Up to 7% of all adrenal incidentalomas (AIs) are pheochromocytomas (PCCs). In the evaluation AI, it is generally recommended that PCC be excluded by measurement plasma-free or 24-hour urinary fractionated metanephrines. However, recent studies suggest biochemical exclusion not performed for lesions with CT characteristics an adrenocortical adenoma (ACA).
Primary aldosteronism is the most frequent cause of secondary hypertension and associated with increased morbidity mortality compared hypertensive controls. The central diagnostic challenge differentiation between bilateral unilateral disease, which determines treatment options. Bilateral adrenal venous sampling, currently recommended for differential diagnosis, an invasive procedure several drawbacks, making it desirable to develop novel noninvasive tools. When investigating expression...
Representative data on diagnostic findings in primary hypophysitis (PrHy) are scarce.The objective of the study was to collate consistent clinical features a large series patients with PrHy. Another gain information current practice work-up.The Pituitary Working Group German Society Endocrinology conducted nationwide retrospective cross-sectional cohort Germany.Seventy-six PrHy were identified.Clinical and endocrinological assessed.Headache (50%) increase body mass (18%) most frequent...
The best treatment of primary hypophysitis (PrHy) is a matter debate.Our main objective was to analyze the practice for PrHy in Germany and compare outcome options.The Pituitary Working Group German Society Endocrinology conducted nationwide retrospective cross-sectional cohort study.Seventy-six patients with were eligible study.Clinical endocrinological outcomes, side effects complications therapy, initial response, recurrence rates assessed. Outcome depending on modality evaluated.For mere...
Objective Hypertension and symptoms of catecholamine excess are features pheochromocytomas paragangliomas (PPGLs). This prospective observational cohort study assessed whether differences in presenting patients tested for PPGLs might assist establishing likelihood disease. Design methods Patients were because signs symptoms, an incidental mass on imaging or routine surveillance due to previous history hereditary risk. with ( n = 245) compared without 1820) identified follow-up. Differences...
Medical treatment in Cushing's disease (CD) is limited due to poor understanding of its pathogenesis. Pathogenic variants ubiquitin specific peptidase 8 (USP8) have been confirmed as causative around half corticotroph tumors. We aimed further characterize the molecular landscape those CD tumors lacking USP8 mutations a large cohort patients.Exome sequencing was performed on 18 paired tumor-blood samples with wild-type status. Candidate gene were screened by Sanger 175 additional samples. The...
To describe clinical and pathological characteristics treatment outcomes in a large cohort of aggressive pituitary tumours (APT)/pituitary carcinomas (PC).Electronic survey August 2020-May 2021.96% 171 (121 APT, 50 PC), initially presented as macro/giant tumours, 6 were microadenomas (5 corticotroph). Ninety-seven considered clinically benign, demonstrated behaviour after 5.5 years (IQR: 2.8-12). Of the patients, 63% men. Adrenocorticotrophic hormone (ACTH)-secreting constituted 30% APT/PC,...
Abstract Context Despite prolactin´s (PRL) role in stimulating hematopoiesis, anemia is commonly observed men with macroprolactinomas. However, hematological changes microprolactinomas and women prolactinomas remain unexplored, the impact of erythropoietic alterations on quality life (QoL) still unclear. Objective To explore sex-related red blood cell (RBC) parameters their potential QoL at initial diagnosis prolactinoma after normalization PRL under dopamine agonists. Design Retrospective,...
Adrenocortical carcinoma (ACC) is rare and confers an unfavorable prognosis in advanced stages. Other than combination chemotherapy with cisplatin, etoposide, doxorubicin, mitotane, the second- third-line regimens are not well-established. Gemcitabine (GEM)-based was suggested a phase 2 clinical trial 28 patients. In other solid tumors, human equilibrative nucleoside transporter type 1 (hENT1) and/or ribonucleotide reductase catalytic subunit M1 (RRM1) expression have been associated...
Background Salivary cortisol is increasingly used to assess patients with suspected hypo- and hypercortisolism. This study established disease-specific reference ranges for an automated electrochemiluminescence immunoassay (ECLIA). Methods Unstimulated saliva from 62 hypothalamic–pituitary disease was collected at 0800 h. A peak serum level below 500 nmol/l during the insulin tolerance test (ITT) identify hypocortisolism. Receiver-operating characteristic (ROC) analysis allowed establishment...