A5035705338- Hormonal Regulation and Hypertension
- Adrenal and Paraganglionic Tumors
- Hormonal and reproductive studies
- Stress Responses and Cortisol
- Regulation of Appetite and Obesity
- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Cannabis and Cannabinoid Research
- Pituitary Gland Disorders and Treatments
- Adrenal Hormones and Disorders
- Ovarian function and disorders
- Diet, Metabolism, and Disease
- Cancer, Hypoxia, and Metabolism
- Thyroid Cancer Diagnosis and Treatment
- Pancreatic function and diabetes
- Growth Hormone and Insulin-like Growth Factors
- Sleep and Wakefulness Research
- Radiomics and Machine Learning in Medical Imaging
- Lipid metabolism and disorders
- Eating Disorders and Behaviors
- Parathyroid Disorders and Treatments
- Dietary Effects on Health
- Cardiovascular Disease and Adiposity
- Pancreatic and Hepatic Oncology Research
- Diabetes Treatment and Management
Azienda USL di Bologna
2021-2025
University of Bologna
2016-2025
Policlinico S.Orsola-Malpighi
2014-2025
Bristol-Myers Squibb (Switzerland)
2024
Istituti di Ricovero e Cura a Carattere Scientifico
2021-2024
GlaxoSmithKline (India)
2024
Takeda (United States)
2024
AbbVie (United States)
2024
Oncopeptides (Sweden)
2024
March of Dimes
2019
Abdominal obesity and hyperinsulinemia play a key role in the development of polycystic ovary syndrome (PCOS). Dietary-induced weight loss administration insulin-lowering drugs, such as metformin, are usually followed by improved hyperandrogenism related clinical abnormalities. This study was carried out to evaluate effects combined hypocaloric diet metformin on body weight, fat distribution, glucose-insulin system, hormones group 20 obese PCOS women[ mass index (BMI) > 28 kg/m2] with...
In addition to its orexigenic properties, ghrelin has been shown modulate the secretory pattern of pituitary hormones, and it may exert direct effects on peripheral organs such as gonads endocrine pancreas. To study possible interactions among ghrelin, glucose homeostasis, reproductive system, we investigated 10 obese women with polycystic ovary syndrome (OB-PCOS) in comparison age- body mass index-matched subjects (OB). Plasma levels insulin, glucose, androgens, were measured at baseline...
There are no studies in vivo on the effects of insulin androgens and sex hormone-binding globulin (SHBG) men. We, therefore, investigated suppression testosterone SHBG two groups eight nondiabetic adult obese men six healthy normal weight who underwent diazoxide treatment (100 mg, three times daily) for 7 days. Blood samples hormone determination were obtained before subjects had been selected study, immediately administration, last day treatment. A 24-h oral glucose tolerance test was also...
Subclinical Cushing's syndrome (SCS) is defined as alterations in hypothalamic-pituitary-adrenal axis without classic signs/symptoms of glucocorticoid excess. Whether SCS leads to metabolic and cardiovascular diseases still controversial.To evaluate the prevalence hypertension, type 2 diabetes (T2D), coronary heart disease (CHD), ischemic stroke, osteoporosis, fractures, their relationship increasing patterns subclinical hypercortisolism, patients with nonsecreting adrenal adenomas (NSA)...
Type 2 diabetes mellitus is the result of interaction between genetic and environmental factors, leading to heterogeneous progressive pancreatic β -cell dysfunction. Overweight obesity are major contributors development insulin resistance impaired glucose tolerance. The inability cells secrete enough produces type diabetes. Abnormalities in other hormones such as reduced secretion incretin glucagon-like peptide 1 (GLP-1), hyperglucagonemia, raised concentrations counterregulatory also...
Chronic exposure to environmental stress may play a role in the development of obesity, through hyperactivation hypothalamic-pituitary-adrenocortical (HPA) axis. This study investigated dynamics weight gain and activity HPA axis women who developed after stressful event. is case-control retrospective study. Two groups age-matched premenopausal were selected. One (n = 14) included characterized by rapid following event, defined as "stress-related obesity " (SRO) group, other 21) with...
Abstract Objective Mild autonomous cortisol secretion (MACS) has been associated with a higher prevalence of osteoporosis, although most data rely on single-center studies limited sample size. We aimed to assess the fragility fractures and contributing factors in large cohort patients adrenal incidentalomas. Design Methods Medical records 1023 incidentalomas from 1990 2019 were reviewed, 735 selected. Clinically obtained electronic radiological images closest first endocrine evaluation, such...
The aim of this study was to investigate the phenotypic parameters and associated factors characterizing development glucose intolerance in polycystic ovary syndrome (PCOS). Among 121 PCOS female subjects from Mediterranean region, 15.7 2.5% displayed impaired tolerance type 2 diabetes, respectively. These were included a single group overweight or obese presenting with (GI) states. women normal (81.8%) subdivided into two groups: those who weight. Metabolic hormonal characteristics GI...
Little is known about the natural history of polycystic ovary syndrome (PCOS), although preliminary data indicate that affected women are more susceptible than general population to diabetes and cardiovascular diseases at post-menopausal ages. The aim this study was follow-up all main features metabolic in a group young with PCOS investigate long-term effects on metabolism body composition oestrogen-progestagen (OP) compounds, which frequently used these treat hyperandrogenism related...
We have previously shown that women with abdominal body fat distribution (A-BFD) a hyperactive hypothalamic-pituitary-adrenal (HPA) axis. However, we did not consider the presence of anxiety and/or depression, common manifestations in obese subjects. Anxiety and depression may be associated oversecretion cortisol could represent confounding factor evaluation HPA axis different obesity phenotypes. In this study nondepressed peripheral (P-BFD) control lean group underwent CRH/AVP stimulation...
To contribute to the anthropometric and metabolic phenotyping of orexin-A-deficient narcoleptic patients, explore a possible risk their developing syndrome.We performed cross-sectional study comparing alterations in patients with narcolepsy cataplexy (NC) idiopathic hypersomnia without long sleep time.University hospital.Fourteen 14 sex age-matched time.N/A.Metabolic parameters were evaluated by measuring body mass index (BMI), waist circumference (also abdominal computed tomography), blood...
The elucidation of the role endocannabinoids in physiological and pathological conditions transferability importance these mediators from basic evidence into clinical practice is still hampered by indefiniteness their circulating reference intervals. In this work, we developed validated a two-dimensional LC/MS/MS method for simultaneous measurement plasma related compounds such as arachidonoyl-ethanolamide, palmitoyl-ethanolamide, oleoyl-ethanolamide, belonging to N-acyl-ethanolamide (NAE)...
Long-term follow-up studies revealed that patients with subclinical hypercortisolism (SH) due to adrenocortical adenomas have an increased incidence of cardiovascular diseases and mortality. No yet investigated the steroid profile its implications in SH. The objective study was analyze by liquid chromatography-tandem mass spectrometry sera from unilateral adenomas. This a cross-sectional study. conducted at outpatient clinic. Patients (nonsecreting, n = 66; SH, 28) 188 age- sex-matched...