A5036008481- Adrenal and Paraganglionic Tumors
- Cancer, Hypoxia, and Metabolism
- Pituitary Gland Disorders and Treatments
- Hormonal Regulation and Hypertension
- Glioma Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Neuroblastoma Research and Treatments
- Adrenal Hormones and Disorders
- Lung Cancer Research Studies
- Vitamin D Research Studies
- Cancer Genomics and Diagnostics
- Pancreatic and Hepatic Oncology Research
- Growth Hormone and Insulin-like Growth Factors
- CAR-T cell therapy research
- Bone health and osteoporosis research
- Mitochondrial Function and Pathology
- Hormonal and reproductive studies
- Cancer, Lipids, and Metabolism
- Lipid Membrane Structure and Behavior
- ATP Synthase and ATPases Research
- Vitamin C and Antioxidants Research
- Congenital heart defects research
- Renal cell carcinoma treatment
- Myasthenia Gravis and Thymoma
- Caveolin-1 and cellular processes
Universitätsklinikum Würzburg
2015-2025
University of Würzburg
2017-2025
Università Cattolica del Sacro Cuore
2013-2024
University of the Sacred Heart
2024
Istituti di Ricovero e Cura a Carattere Scientifico
2024
Ospedale Policlinico San Martino
2022
Federico II University Hospital
2018-2020
University of Naples Federico II
2018-2020
University of L'Aquila
2014-2019
Regione Puglia
2019
Abstract Context Adrenocortical carcinoma (ACC) has a heterogeneous prognosis, and current medical therapies have limited efficacy in its advanced stages. Genome-wide multiomics studies identified molecular patterns associated with clinical outcome. Objective Here, we aimed at identifying signature useful for both personalized prognostic stratification druggable targets, using methods applicable routine. Design In total, 117 tumor samples from 107 patients ACC were analyzed. Targeted...
Adrenocortical carcinoma (ACC) is a rare endocrine malignancy. Tumor-related glucocorticoid excess present in ~60% of patients and associated with particularly poor prognosis. Results first clinical trials using immune checkpoint inhibitors were heterogeneous. Here we characterize tumor-infiltrating T lymphocytes (TILs) ACC association glucocorticoids as potential explanation for resistance to immunotherapy.We performed immunofluorescence analysis visualize cells (CD3+), helper (CD3+CD4+),...
Adrenocortical carcinoma (ACC) has an aggressive but variable clinical course. Prognostic stratification based on the European Network for Study of Adrenal Tumours stage and Ki67 index is limited. We aimed to demonstrate prognostic role a points-based score (S-GRAS) in large cohort patients with ACC.This multicentre, retrospective study ACC who underwent adrenalectomy.The S-GRAS was calculated as sum following points: tumour (1-2 = 0; 3 1; 4 2), grade (Ki67 0-9% 10-19% ≥20% 2 points),...
Abstract Context Despite prolactin´s (PRL) role in stimulating hematopoiesis, anemia is commonly observed men with macroprolactinomas. However, hematological changes microprolactinomas and women prolactinomas remain unexplored, the impact of erythropoietic alterations on quality life (QoL) still unclear. Objective To explore sex-related red blood cell (RBC) parameters their potential QoL at initial diagnosis prolactinoma after normalization PRL under dopamine agonists. Design Retrospective,...
Adrenocortical carcinoma (ACC) is a rare malignancy with no widely available biomarkers and commonly presents at later stages bleak prognosis [1]. Dysregulation of signaling pathways involved in the organogenesis homeostasis adrenal cortex implicated its pathogenesis [2]. The paternally expressed, cleavable protein delta-like non-canonical Notch ligand 1 (DLK1) expressed rat adrenocortical progenitor cells [3] clusters relatively undifferentiated human gland [4]. Its expression most adult...
Adrenocortical carcinoma (ACC) is rare and confers an unfavorable prognosis in advanced stages. Other than combination chemotherapy with cisplatin, etoposide, doxorubicin, mitotane, the second- third-line regimens are not well-established. Gemcitabine (GEM)-based was suggested a phase 2 clinical trial 28 patients. In other solid tumors, human equilibrative nucleoside transporter type 1 (hENT1) and/or ribonucleotide reductase catalytic subunit M1 (RRM1) expression have been associated...
Neuroendocrine tumors (NETs) are rare neoplasms mostly originating from the gastroenteropancreatic tract (GEP-NETs). Data regarding nutritional status in GEP-NET patients limited. The aim of study was to investigate and adherence Mediterranean Diet (MD) correlate them with tumor aggressiveness. A cross-sectional case-control observational conducted enrolling 83 well-differentiated G1/G2 GEP-NETs after resection, as well healthy subjects, age, sex body mass index-matched. Nutritional assessed...
Abstract Context Because of the rarity adrenocortical cancer (ACC), only a few population-based studies are available, and they reported limited details in characterization patients their treatment. Objective To describe nationwide cohort presentation with ACC, treatment strategies, potential prognostic factors. Methods Retrospective analysis 512 diagnosed 12 referral centers Italy from January 1990 to June 2018. Results ACC as incidentalomas accounted for overall 38.1% cases, frequency that...
Abstract Objective Bilateral inferior petrosal sinus sampling (BIPSS) is regarded as the gold standard to differentiate between Cushing´s disease (CD) and ectopic Cushing's syndrome (ECS). However, published data on diagnostic value of additional prolactin analysis are controversial. Thus, we evaluated performance BIPSS with without in a multicenter study. Design methods Retrospective study five European reference centers. Patients overt adrenocorticotropin (ACTH)-dependent at time human...
Abstract Context Cushing syndrome (CS) is associated with different hematological abnormalities. Nevertheless, conflicting data about erythropoiesis in CS have been reported. Furthermore, it unclear whether sex and subtype-specific alterations red blood cells (RBC) parameters are present. Objective To investigate changes RBC patients at initial diagnosis after remission. Design Retrospective, monocentric study including 210 (women, n = 162) matched 1:1 for age to pituitary microadenomas or...
Abstract International guidelines emphasise the role of local therapies (LT) for treatment advanced adrenocortical carcinoma (ACC). However, large studies are lacking in this field. Therefore, we performed a review literature to synthesise current evidence and develop clinical guidance. PubMed database was searched systematic literature. We identified 119 potentially relevant articles, which 21 could be included our final analysis. All were retrospective reported on 374 patients treated with...
Background Adrenocortical tumors comprise frequent adenomas (ACA) and rare carcinomas (ACC). Human cytochrome P450 2W1 (CYP2W1) is highly expressed in some cancers holding the potential to activate certain drugs into tumor cytotoxins. Objective To investigate CYP2W1 expression adrenal samples its relationship with clinical outcome ACC. Material Methods was investigated by qRT-PCR 13 normal glands, 32 ACA, 25 ACC, 9 different non-adrenal tissue immunohistochemistry 352 specimens (23 33 239 67...
Abstract Purpose Pancreatic neuroendocrine tumors (pNETs) are frequent in multiple endocrine neoplasia type 1 (MEN1) syndrome. They usually not surgically treated unless larger than to 2 cm or a growth rate > 0.5 per year. Somatostatin analogues represent one of the main therapeutic options pNETs, but they have never been prospectively investigated MEN1-related pNETs. The aim this study was evaluate effectiveness lanreotide patients with pNETs < cm. Methods MEN1 more maximal...
Background Obesity, mainly visceral obesity, and metabolic syndrome (MetS) are major risk factors for the development of type 2 diabetes, cardiovascular diseases, cancer. Data analyzing association obesity MetS with gastroenteropancreatic neuroendocrine neoplasms (GEP-NEN) lacking. Fatty liver index (FLI) is a non-invasive tool identifying individuals non-alcoholic fatty disease (NAFLD). Visceral adiposity (VAI) has been suggested as gender-specific indicator adipose dysfunction. Both...
International guidelines recommend local therapies (LTs) such as thermal ablation (LTA; radiofrequency, microwave, cryoablation), transarterial (chemo)embolisation (TA(C)E), and radioembolisation (TARE) therapeutic options for advanced adrenocortical carcinoma (ACC). However, the evidence these recommendations is scarce. We retrospectively analysed patients receiving LTs ACC. Time to progression of treated lesion (tTTP) was primary endpoint. The secondary endpoints were best objective...
Adrenocortical carcinoma (ACC) is a rare endocrine malignancy with poor prognosis in advanced stages. While therapies targeting the checkpoint molecules programmed cell death 1 (PD-1), its ligand PD-L1, and cytotoxic T lymphocyte-associated protein 4 (CTLA-4) have revolutionized treatment many cancers, results ACCs were heterogeneous.