A5026158873- Pituitary Gland Disorders and Treatments
- Adrenal and Paraganglionic Tumors
- Adrenal Hormones and Disorders
- Hormonal Regulation and Hypertension
- Growth Hormone and Insulin-like Growth Factors
- Cancer, Hypoxia, and Metabolism
- Glioma Diagnosis and Treatment
- MicroRNA in disease regulation
- Ion Transport and Channel Regulation
- Myasthenia Gravis and Thymoma
- Hormonal and reproductive studies
- Receptor Mechanisms and Signaling
- 14-3-3 protein interactions
- Neurological diseases and metabolism
- Nutrition and Health in Aging
- Coenzyme Q10 studies and effects
- Gut microbiota and health
- Blood Pressure and Hypertension Studies
- Peroxisome Proliferator-Activated Receptors
- Olfactory and Sensory Function Studies
- Medical Imaging Techniques and Applications
- Trigeminal Neuralgia and Treatments
- Biochemical Analysis and Sensing Techniques
- Oropharyngeal Anatomy and Pathologies
- Exercise and Physiological Responses
Ludwig-Maximilians-Universität München
2014-2024
LMU Klinikum
2015-2024
University of Zurich
2023
Justus-Liebig-Universität Gießen
2023
München Klinik
2013-2014
University of Würzburg
2014
Institut für Urheber- und Medienrecht
2014
Corticotropin-independent Cushing's syndrome is caused by tumors or hyperplasia of the adrenal cortex. The molecular pathogenesis cortisol-producing adenomas not well understood.
Recurrence of adrenocortical carcinoma (ACC) even after complete (R0) resection occurs frequently. The aim this study was to identify markers with prognostic value for patients in clinical setting. From the German ACC registry, 319 European Network Study Adrenal Tumors stage I–III were identified. As an independent validation cohort, 250 from three countries included. Clinical, histological, and immunohistochemical correlated recurrence-free (RFS) overall survival (OS). Although univariable...
Bilateral adrenalectomy (BADX) is an important treatment option for patients with Cushing's syndrome (CS). Our aim to analyze the long-term outcomes, surgical, biochemical, and clinical as well morbidity mortality, of who underwent BADX.A total 50 BADX since 1990 in two German centers were identified. Of them, 34 had disease (CD), nine ectopic CS (ECS), seven ACTH-independent bilateral adrenal hyperplasia (BAH).Standardized follow-up examination was performed 36 a minimum time 6 months after...
Abstract BACKGROUND Diagnosis of Cushing syndrome requires a multistep process that includes verification hypercortisolism followed by identification the cause adrenocortical hyperfunction. This study assessed whether pituitary, ectopic, and adrenal subtypes were characterized distinct plasma steroid profiles might assist diagnosis. METHODS In this retrospective cross-sectional study, mass spectrometric measurements panel 15 steroids applied to 222 patient samples tested for syndrome....
Successful tumor resection in endogenous Cushing's syndrome (CS) results tertiary adrenal insufficiency requiring hydrocortisone replacement therapy.The aim was to analyze the postsurgical duration of patients with disease (CD), CS, and ectopic CS.We performed a retrospective analysis based on case records 230 CS our referral center treated from 1983-2014. The mean follow-up time 8 years.We included 91 three subtypes undergoing curative intended surgery documented followup after excluding...
ContextUnilateral adrenalectomy has been proposed in selected patients with primary bilateral macronodular adrenocortical hyperplasia (PBMAH), but its long-term outcome is unclear.
Cushing's syndrome (CS) is characterized by an excessive secretion of glucocorticoids that results in a characteristic clinical phenotype. One feature hypercortisolism breakdown protein metabolism translating into consequences including glucocorticoid-induced myopathy. While surgery effective control cortisol excess, the effect biochemical remission on muscular function yet unclear.In cross-sectional study we analyzed 47 patients with CS during florid phase (ActiveCS). 149 additional were...
Brown adipose tissue (BAT) is a metabolically highly active organ with increased thermogenic activity in rodents exposed to cold temperature. Recently its presence the cervical of human adults and association favorable metabolic phenotype have been reported.The objective study was determine prevalence retroperitoneal BAT adults.This an observational cohort study.The conducted at tertiary referral hospital.Fifty-seven patients who underwent surgery for benign adrenal tumors were included this...
Abstract Context Pathogenesis of autonomous steroid secretion and adrenocortical tumorigenesis remains partially obscure. Objective To investigate the relationship between transcriptome profile genetic background in a large series tumors identify new potential pathogenetic mechanisms. Design Cross-sectional study. Setting University Hospitals European Network for Study Adrenal Tumors (ENSAT). Patients We collected snap-frozen tissue from patients with (n = 59) known background: 26 adenomas...
Objective The aim of the present study was to validate criteria corticotropin-releasing hormone (CRH) stimulation and 8 mg dexamethasone suppression (high-dose suppression, HDDS) distinguish etiology ACTH-dependent Cushing's syndrome. Subjects methods We retrospectively analyzed cortisol ACTH after injection 100 μg human CRH in confirmed disease (CD, n =78) ectopic syndrome (ECS, =18). Cortisol increase (in percentage above basal (% B )) at each time point, maximal (Δmax % ), area under...
Objective Aim of our study was to analyze long-term outcome patients with the ectopic Cushing’s syndrome (ECS) compared disease (CD) regarding cardiovascular, metabolic, musculoskeletal and psychiatric comorbidities. Design Cross-sectional in ECS CD two German academic tertiary care centers. Methods Standardized clinical follow-up examination performed including health-related quality life (QoL) 21 remission (≥18 months since successful surgery). Fifty-nine served as controls. Results Time...
In depth analysis of key molecular mechanisms involved in functional autonomy aldosterone secretion is hampered by the lack tumor cell lines that reflect characteristics producing adenomas. Herein, we describe adrenocortical carcinoma line NCI-H295R and its suitability as a model hyperaldosteronism relation to different culture conditions. Steroid profiling revealed cells predominantly secrete cortisol, while other steroids are released at much lower concentrations. However, output...
Cushing's syndrome (CS) is a rare disease of endogenous hypercortisolism associated with high morbidity and mortality. Diagnosis classification CS still challenging.Circulating microRNAs (miRNAs) are minimally invasive diagnostic markers. Our aim was to characterize the circulating miRNA profiles patients identify distinct between two major subtypes.We included three groups from German registry: ACTH-independent (Cortisol-Producing-Adenoma; CPA), ACTH-dependent pituitary (Cushing's Disease;...
Primary bilateral macronodular adrenocortical hyperplasia (PBMAH) is a rare cause of ACTH-independent Cushing's syndrome. Current guidelines recommend adrenalectomy for PBMAH, but several studies showed clinical effectiveness unilateral despite disease in selected patients. Our aim was to evaluate the gain information which can be obtained through adrenal venous sampling (AVS) based cortisol lateralization ratios guidance adrenalectomy.We performed retrospective analysis 16 patients with...