A5039569722- Pituitary Gland Disorders and Treatments
- Adrenal Hormones and Disorders
- Adrenal and Paraganglionic Tumors
- Growth Hormone and Insulin-like Growth Factors
- Hormonal Regulation and Hypertension
- Thyroid and Parathyroid Surgery
- Myasthenia Gravis and Thymoma
- Diet and metabolism studies
- Psychology, Coaching, and Therapy
- Glioma Diagnosis and Treatment
- Blood properties and coagulation
- Sociology and Education Studies
- Sympathectomy and Hyperhidrosis Treatments
- Nutrition and Health in Aging
- Cancer, Lipids, and Metabolism
- Parathyroid Disorders and Treatments
- Clinical Laboratory Practices and Quality Control
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Biomedical Text Mining and Ontologies
- Restraint-Related Deaths
- Lipoproteins and Cardiovascular Health
- Thyroid Cancer Diagnosis and Treatment
- Ophthalmology and Eye Disorders
- Topic Modeling
- Thermoregulation and physiological responses
University of Augsburg
2022-2025
University Hospital Augsburg
2021-2022
LMU Klinikum
2014-2019
Ludwig-Maximilians-Universität München
2015-2019
Max Planck Institute of Psychiatry
2016
Ruhr University Bochum
2016
RESULTS and RESULTS Educational Fund
2016
München Klinik
2015
We have recently reported somatic mutations in the ubiquitin-specific protease USP8 gene a small series of adenomas patients with Cushing's disease.To determine prevalence and genotype-phenotype correlation large diagnosed disease.We performed retrospective, multicentric, genetic analysis 134 functioning 11 silent corticotroph using Sanger sequencing. Biochemical clinical features were collected examined within context mutational status USP8, new characterized by functional studies.A total...
Successful tumor resection in endogenous Cushing's syndrome (CS) results tertiary adrenal insufficiency requiring hydrocortisone replacement therapy.The aim was to analyze the postsurgical duration of patients with disease (CD), CS, and ectopic CS.We performed a retrospective analysis based on case records 230 CS our referral center treated from 1983-2014. The mean follow-up time 8 years.We included 91 three subtypes undergoing curative intended surgery documented followup after excluding...
Abstract Context Cushing syndrome (CS) is a rare and serious disease with high mortality. Patients are often diagnosed late in the course of disease. Objective This work investigated whether defined patient populations should be screened outside at-risk current guidelines. Methods As part prospective German registry, we studied 377 patients suspected CS. The chief complaint for CS referral was documented. Using urinary free cortisol, late-night salivary 1-mg dexamethasone suppression test as...
Cushing's syndrome (CS) is characterized by an excessive secretion of glucocorticoids that results in a characteristic clinical phenotype. One feature hypercortisolism breakdown protein metabolism translating into consequences including glucocorticoid-induced myopathy. While surgery effective control cortisol excess, the effect biochemical remission on muscular function yet unclear.In cross-sectional study we analyzed 47 patients with CS during florid phase (ActiveCS). 149 additional were...
Objective The aim of the present study was to validate criteria corticotropin-releasing hormone (CRH) stimulation and 8 mg dexamethasone suppression (high-dose suppression, HDDS) distinguish etiology ACTH-dependent Cushing's syndrome. Subjects methods We retrospectively analyzed cortisol ACTH after injection 100 μg human CRH in confirmed disease (CD, n =78) ectopic syndrome (ECS, =18). Cortisol increase (in percentage above basal (% B )) at each time point, maximal (Δmax % ), area under...
Current first-line screening tests for Cushing's syndrome (CS) only measure time-point or short-term cortisol. Hair cortisol content (HCC) offers a non-invasive way to long-term exposure over several months of time. We aimed evaluate HCC as tool CS.Case-control study in two academic referral centers CS.Between 2009 and 2016, we collected scalp hair from patients suspected CS healthy controls. was measured using ELISA. available 43 confirmed patients, 35 whom the diagnosis rejected during...
Objective Endogenous hypercortisolism is a chronic condition associated with severe metabolic disturbances and cardiovascular sequela. The aim of this study was to characterize alterations in patients different degrees by mass-spectrometry-based targeted plasma metabolomic profiling correlate the profile clinical hormonal data. Design Cross-sectional study. Methods Subjects ( n = 149) were classified according characteristics: Cushing’s syndrome 46), adrenocortical adenomas autonomous...
Objective Aim of our study was to analyze long-term outcome patients with the ectopic Cushing’s syndrome (ECS) compared disease (CD) regarding cardiovascular, metabolic, musculoskeletal and psychiatric comorbidities. Design Cross-sectional in ECS CD two German academic tertiary care centers. Methods Standardized clinical follow-up examination performed including health-related quality life (QoL) 21 remission (≥18 months since successful surgery). Fifty-nine served as controls. Results Time...
Abstract Objective Ectopic Cushing′s syndrome (ECS) induced by medullary thyroid cancer (MTC) is rare, and data on clinical characteristics, treatment outcome are limited. Design Retrospective cohort study in three German one Swiss referral centres. Patients Eleven patients with MTC occurrence of ECS 22 matched without were included. Measurements The primary endpoint this was the overall survival (OS) versus 1:2 ECS. Results median age at diagnosis 59 years (range: 35–81) time between...
Abstract Objective Cushing’s syndrome is a rare disease characterized by clinical features that show morphological similarity with the metabolic syndrome. Distinguishing these diseases in practice challenging. We have previously shown computer vision technology can be potentially useful diagnostic tool In this follow-up study, we addressed described problem increasing sample size and including controls matched body mass index. Methods enrolled 82 patients (22 male, 60 female) 98 control...
Abstract Background Clinical care of patients with cyclic Cushing’s syndrome (CS) is challenging. Classical pitfalls include incorrect subtyping, unnecessary surgical procedures and delayed definite treatment. Case presentation A 43-year-old female suffered from a rapidly cycling ectopic CS. She experienced six cycles severe hypercortisolism within 2 year period (maximum plasma cortisol 5316 nmol/L, normal range 124.2–662.4 nmol/L; maximum urinary free 79,469 nmol/24 h, < 414 h) lasting...
Abstract Context An important clinical feature of Cushing’s syndrome (CS) is proximal muscle myopathy caused by glucocorticoid induced protein metabolism. However, interindividual differences cannot be explained solely the pure extent hypercortisolemia. Objective To evaluate effects receptor (GR) polymorphisms (BclI, N363S, ER22/23EK and A3669G), which influence peripheral sensitivity on muscular function in endogenous CS. Methods 205 patients with proven CS (128 central, 77 adrenal) from 3...
[08:00 – 08:10]We have recently reported that somatic mutations in the ubiquitin-specific peptidase USP8 are present corticotropinomas of patients with Cushing's disease and these reduced interaction 14 3-3. Mutant exhibited higher deubiquitination activity promoted POMC expression an EGFR-depending fashion (Reincke et al., Nat. Genetics 2014). To further study prevalence mutations, we analyzed 145 ACTH-producing diagnosed from 8 different centers by Sanger sequencing.
Context: Successful tumor resection in endogenous Cushing's syndrome (CS) results tertiary adrenal insufficiency requiring hydrocortisone replacement therapy.
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Cushing's syndrome is associated with increased cardiovascular morbidity and mortality. Aim of our study was to evaluate patients suspected regarding risk factors comorbidities.
Background: The CRH test is widely used for differential diagnosis of ACTH-dependent Cushing's syndrome. aim this study was to validate criteria ACTH and cortisol response after injection in order distinguish the etiology