A5052262272- Stress Responses and Cortisol
- Sleep and Wakefulness Research
- Hormonal Regulation and Hypertension
- Regulation of Appetite and Obesity
- Sleep and related disorders
- Neuropeptides and Animal Physiology
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Circadian rhythm and melatonin
- Tryptophan and brain disorders
- Biochemical Analysis and Sensing Techniques
- Pelvic floor disorders treatments
- Obsessive-Compulsive Spectrum Disorders
- Neuroendocrine regulation and behavior
- Adrenal Hormones and Disorders
- Anesthesia and Pain Management
- Posttraumatic Stress Disorder Research
- Pain Mechanisms and Treatments
- Anesthesia and Neurotoxicity Research
- Treatment of Major Depression
- Eating Disorders and Behaviors
- Neuroscience and Neuropharmacology Research
- Multiple Sclerosis Research Studies
- Pituitary Gland Disorders and Treatments
- Adipose Tissue and Metabolism
- Heart Failure Treatment and Management
Ludwig-Maximilians-Universität München
1990-2025
Max Planck Institute of Psychiatry
2014-2024
Urologische Klinik München
2022
Max Planck Society
2006-2020
LMU Klinikum
2019-2020
München Klinik Bogenhausen
2016
München Klinik
2015
Universität Hamburg
2009
University of St. Gallen
2009
Max Planck Institute of Neurobiology
1988-2000
The cannabinoid receptor type 1 (CB1) and its endogenous ligands, the endocannabinoids, are involved in regulation of food intake. Here we show that lack CB1 mice with a disrupted gene causes hypophagia leanness. As compared WT (CB1+/+) littermates, lacking (CB1-/-) exhibited reduced spontaneous caloric intake and, as consequence total fat mass, decreased body weight. In young CB1-/- mice, lean phenotype is predominantly caused by intake, whereas adult metabolic factors appear to contribute...
Opioids can produce potent antinociceptive effects by interacting with local opioid receptors in inflamed peripheral tissue. In this study we examined the analgesic of intraarticular, as compared intravenous, administration morphine after arthroscopic knee surgery.
There is a genetic contribution to the idiopathic restless legs syndrome (iRLS). An autosomal dominant mode of inheritance suspected, but as yet no gene has been identified. To assess frequency and characteristics hereditary (RLS) in comparison those non-hereditary RLS, we analysed clinical data 300 RLS patients. All patients diagnosed according criteria International Study Group were examined using standard questionnaire covering demographic data, family history, symptoms, subjective sleep...
To assess and compare polygraphic sleep measures periodic leg movement (PLM) patterns in untreated patients with mild to moderate Parkinson's disease (PD), multiple system atrophy (MSA) healthy age-matched controls.Polysomnographic recordings of 2 consecutive nights were performed 10 PD (mean age 65 years, mean Hoehn Yahr stage 2.2), MSA 61 years) a control group subjects 64 years). All controls free antiparkinsonian medication other centrally active drugs for weeks prior...
Copolymer 1 (COP), a standardized mixture of synthetic polypeptides consisting l -glutamic acid, -lysine, -alanine, and -tyrosine, has beneficial effects in multiple sclerosis experimental autoimmune encephalomyelitis. We selected panel 721 COP-reactive T cell lines (TCL) from the blood COP-treated untreated patients healthy donors by using split-well cloning technique. All TCL with COP proliferated response to but not myelin basic protein (MBP). Conversely, 31 control MBP COP. used...
Opioids produce analgesia by interacting with local opioid receptors in peripheral inflamed tissue. This study investigated whether endogenous ligands of these are present synovia and such peptides can inhibit pain activation intra-articular receptors. Samples synovium from 8 patients undergoing arthroscopic knee surgery were examined immunohistochemistry for the presence beta-endorphin, met-enkephalin, dynorphin. All tissue samples showed synovitis. Inflammatory cells stained strongly...
This study was done to compare the effects of 6-week treatment with amitriptyline on hypothalamic-pituitary-adrenocortical (HPA) regulation in elderly depressed patients and age-matched comparison subjects.A combined dexamethasone-suppression/CRH-stimulation (dexamethasone/CRH) test administered before initiation at end weeks 1, 3, 6 treatment. Thirty-nine inpatients, mean age = 69 years, completed study. Fourteen normal volunteers, 67 served as subjects.In relation subjects, had a...
Abstract In major depression, decreased hippocampal volume has been attributed to hypercortisolemia, a frequent sign of the disorder, because in animals an excess corticosteroids led dendritic atrophy, astrogliosis and loss neurons this brain region. The present study is first investigate structural integrity human hippocampus depression following glucocorticoid treatment. Post‐mortem tissue from 15 patients who had or bipolar affective 10 treated with glucocorticoids 16 controls was...
Current hypotheses hold that mechanisms underlying abnormal hypothalamic-pituitary-adrenocortical (HPA) function are causal factors in the precipitation of depression. If this is case, then normalization initially disturbed HPA regulation should indicate a good prognosis and persistent dysregulation be associated with greater likelihood relapse or chronicity.The combined dexamethasone/corticotropin-releasing hormone test was administered twice to inpatients major depression (N = 40), once...
Decreased feedback control of the hypothalamic-pituitary-adrenocortical (HPA) system as revealed by combined dexamethasone and corticotropin-releasing hormone (DEX-CRH) test has been documented in vast majority patients with affective disorders. This finding was interpreted a failure at level glucocorticoid receptor (GR)-mediated action, which apparently fails to restrain HPA activity presence elevated plasma corticosteroid levels. To this hypothesis we conducted DEX/CRH using increasing...
Pain treatment with centrally acting opiates is limited by tolerance. Tolerance a decreasing effect of drug prolonged administration that or related (e.g., endogenous) compound at the same receptor. This often associated downregulation receptors. In peripheral inflamed tissue, both locally expressed opioid peptides and morphine can produce powerful analgesia mediated similar populations We hypothesized chronic presence endogenous opioids in joints might convey receptors tolerance to...
<h3>Background</h3> Inhibitors of steroid synthesis have been reported to exert antidepressive effects, according preliminary findings. <h3>Objective</h3> To test whether the addition metyrapone standard antidepressants induces a more rapid, efficacious, and sustained treatment response in patients with major depression. <h3>Design</h3> Double-blind, randomized, placebo-controlled trial. <h3>Setting</h3> Hospitalized care. <h3>Patients</h3> Sixty-three inpatients a<i>DSM-IV</i>diagnosis...
Selective serotonin reuptake inhibitors (SSRIs) are widely used as effective pharmacological agents to treat depressive disorders. In contrast the SSRIs, which block presynaptic (5-HT) transporter and by this route increase concentration of in synaptic cleft, antidepressant tianeptine enhances neuronal 5-HT thus decreases serotonergic neurotransmission. Both SSRIs clinically effective; however, their opposite modes action challenge prevailing concepts on need enhancement To better understand...
Intraarticular morphine inhibits pain after knee surgery without overt toxicity. This study examined intraarticular in chronic arthritis. We undertook a randomized double-blind comparison between (3 mg), dexamethasone (4 mg) and saline ml) 44 patients with inflammatory arthritis or osteoarthritis of the knee. Pain (the primary outcome measure) was assessed at rest during activity for 6 days using visual analog scale (VAS) McGill questionnaire. Before drug injections on day synovial leukocyte...
Context: Ghrelin affects the hypothalamic-pituitary-gonadal axis in various nonhuman mammalians, predominantly by suppressing secretion of LH. However, for humans, no such evidence exists. Objective: Our objective was to study effect ghrelin on LH and testosterone humans. Design, Participants, Intervention: Nocturnal (2000–0700 h) profiles were determined 10 healthy males (25.7 ± 3.0 yr) twice, receiving 50 μg or placebo at 2200, 2300, 2400, 0100 h, this single-blind, randomized, cross-over...
Abstract Objective: Associations between body mass index (BMI) and mental disorders meeting Axis‐I diagnoses according to the Diagnostic Statistical Manual for Mental Disorders IV (DSM‐IV) were investigated in The Early Developmental Stages of Psychopathology Study a large population‐based sample, which included adolescents young adults both genders first time. Research Methods Procedures: A total 3021 German subjects ranging from 14 24 years age assessed specific DSM‐IV derived modified...