A5003733000- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Adipokines, Inflammation, and Metabolic Diseases
- Regulation of Appetite and Obesity
- Mitochondrial Function and Pathology
- Muscle metabolism and nutrition
- Receptor Mechanisms and Signaling
- Pharmacology and Obesity Treatment
- Nitric Oxide and Endothelin Effects
- Obesity, Physical Activity, Diet
- Cardiovascular Disease and Adiposity
- Cancer, Hypoxia, and Metabolism
- Neurotransmitter Receptor Influence on Behavior
- COVID-19 Clinical Research Studies
- Eating Disorders and Behaviors
- Muscle Physiology and Disorders
- Exercise and Physiological Responses
- Diabetes and associated disorders
- Sirtuins and Resveratrol in Medicine
- Nutrition and Health in Aging
- Nutritional Studies and Diet
- Biochemical Analysis and Sensing Techniques
- Cannabis and Cannabinoid Research
- SARS-CoV-2 and COVID-19 Research
- Neuropeptides and Animal Physiology
University of Milan
2016-2025
University of Milano-Bicocca
2022
Politecnico di Milano
2017
European Association for the Study of Obesity
2016
Italian Society of Physiotherapy
2014
IRCCS Istituto Auxologico Italiano
2002-2011
University of Brescia
1988-2008
University of Florence
2008
Mario Negri Institute for Pharmacological Research
2008
Marche Polytechnic University
2008
Nitric oxide was found to trigger mitochondrial biogenesis in cells as diverse brown adipocytes and 3T3-L1, U937, HeLa cells. This effect of nitric dependent on guanosine 3′,5′-monophosphate (cGMP) mediated by the induction peroxisome proliferator–activated receptor γ coactivator 1α, a master regulator biogenesis. Moreover, induced exposure cold markedly reduced adipose tissue endothelial synthase null-mutant (eNOS –/– ) mice, which had metabolic rate accelerated weight gain compared...
The cannabinoid receptor type 1 (CB1) and its endogenous ligands, the endocannabinoids, are involved in regulation of food intake. Here we show that lack CB1 mice with a disrupted gene causes hypophagia leanness. As compared WT (CB1+/+) littermates, lacking (CB1-/-) exhibited reduced spontaneous caloric intake and, as consequence total fat mass, decreased body weight. In young CB1-/- mice, lean phenotype is predominantly caused by intake, whereas adult metabolic factors appear to contribute...
Calorie restriction extends life span in organisms ranging from yeast to mammals. Here, we report that calorie for either 3 or 12 months induced endothelial nitric oxide synthase (eNOS) expression and 3′,5′-cyclic guanosine monophosphate formation various tissues of male mice. This was accompanied by mitochondrial biogenesis, with increased oxygen consumption adenosine triphosphate production, an enhanced sirtuin 1. These effects were strongly attenuated eNOS null-mutant Thus, plays a...
We recently found that long-term exposure to nitric oxide (NO) triggers mitochondrial biogenesis in mammalian cells and tissues by activation of guanylate cyclase generation cGMP. Here, we report the NO/cGMP-dependent is associated with enhanced coupled respiration content ATP U937, L6, PC12 cells. The observed increase depended entirely on oxidative phosphorylation, because formation glycolysis was unchanged. Brain, kidney, liver, heart, gastrocnemius muscle from endothelial NO synthase...
The characteristic structural organization of mitochondria is the product synthesis macromolecules within together with import proteins and lipids synthesized outside organelle. Synthetic processes are required for mitochondrial proliferation might also facilitate growth pre-existing mitochondria. Recent evidence indicates that these events regulated in a complex way by several agonists environmental conditions, through activation specific signaling pathways transcription factors. A newly...
Insulin resistance and obesity are associated with a reduction of mitochondrial content in various tissues mammals. Moreover, reduced nitric oxide (NO) bioavailability impairs several cellular functions, including biogenesis insulin-stimulated glucose uptake, two important mechanisms body adaptation response to physical exercise. Although these have been thoroughly investigated skeletal muscle heart, few studies focused on the effects exercise mitochondria metabolism adipose tissue. In this...
OBJECTIVE—Cannabinoid type 1 (CB1) receptor blockade decreases body weight and adiposity in obese subjects; however, the underlying mechanism is not yet fully understood. Nitric oxide (NO) produced by endothelial NO synthase (eNOS) induces mitochondrial biogenesis function adipocytes. This study was undertaken to test whether CB1 increases espression of eNOS white RESEARCH DESIGN AND METHODS—We examined effects on selective pharmacological receptors SR141716 (rimonabant) mouse primary We...
OBJECTIVE Cannabinoid type 1 (CB1) receptor is involved in whole-body and cellular energy metabolism. We asked whether CB1 stimulation was able to decrease mitochondrial biogenesis different metabolically active tissues of obese high-fat diet (HFD)-fed mice. RESEARCH DESIGN AND METHODS The effects selective agonist arachidonyl-2-chloroethanolamide (ACEA) endocannabinoids anandamide 2-arachidonoylglycerol on endothelial nitric oxide synthase (eNOS) expression were examined, as DNA amount...
Dysregulated adipocyte physiology leads to imbalanced energy storage, obesity, and associated diseases, imposing a costly burden on current health care. Cannabinoid receptor type-1 (CB1) plays crucial role in controlling metabolism through central peripheral mechanisms. In this work, adipocyte-specific inducible deletion of the CB1 gene (Ati-CB1–KO) was sufficient protect adult mice from diet-induced obesity metabolic alterations reverse phenotype already obese mice. Compared with controls,...
This study was designed to test the hypothesis that improved mitochondrial biogenesis could help reducing ischemic cerebral injury. We found levels of proliferator-activated receptor γ coactivator 1α and nuclear respiratory factor-1, DNA content other markers function were reduced in primary mouse cortical neurons under oxygen-glucose deprivation (OGD). The glycogen synthase kinase-3 (GSK-3) inhibitor SB216763 activated an efficient program control counteracted OGD-mediated impairment....
Endurance exercise training increases cardiac energy metabolism through poorly understood mechanisms. Nitric oxide (NO) produced by endothelial NO synthase (eNOS) in cardiomyocytes contributes to adaptation. Here we demonstrate that the donor diethylenetriamine-NO (DETA-NO) activated mitochondrial biogenesis and function, as assessed upregulated peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α), nuclear respiratory factor 1, transcription A (Tfam) expression, increased DNA...
Abstract Aims Human epicardial adipose tissue (EAT) plays a crucial role in the development and progression of coronary artery disease, atrial fibrillation, heart failure. Microscopically, EAT is composed adipocytes, nerve tissues, inflammatory, stromovascular, immune cells. Epicardial white tissue, albeit it also has brown fat-like or beige features. No muscle fascia divides myocardium; this allows direct interaction crosstalk between fat myocardium. Thus, might be therapeutic target for...
Mammalian breast adipose tissue is replaced by a milk-secreting gland during pregnancy; the reverse process takes place upon interruption of lactation. Morphological and bromodeoxyuridine studies provide indirect evidence that mouse mammary adipocytes transform into secretory epithelial cells pregnancy revert to after By using Cre-loxP recombination system we show whey acidic protein (WAP)- Cre / R26R mice, in which express lacZ gene pregnancy, contains labeled involution. Conversely,...
The coronavirus disease 2019 (COVID-19) pandemic has spread around the globe, infecting more than ten million individuals, with 500,000 dead; about one half of infected people have recovered. Despite this fact, a subgroup individuals affected by COVID-19 is at greater risk developing worse outcomes and experience high rate mortality. Data on association between obesity are growing; available studies, reported prevalence overweight in patients experiencing severe course, serious complications...