A5006290113- Muscle metabolism and nutrition
- Diet and metabolism studies
- Adipose Tissue and Metabolism
- Autophagy in Disease and Therapy
- Nutrition and Health in Aging
- Muscle Physiology and Disorders
- Mitochondrial Function and Pathology
- Neuroscience and Neuropharmacology Research
- Wound Healing and Treatments
- Amino Acid Enzymes and Metabolism
- Cancer, Hypoxia, and Metabolism
- Biochemical effects in animals
- Metabolism and Genetic Disorders
- Metabolomics and Mass Spectrometry Studies
- Pressure Ulcer Prevention and Management
- Signaling Pathways in Disease
- Pain Mechanisms and Treatments
- Skin Protection and Aging
- Polyamine Metabolism and Applications
- Liver Disease Diagnosis and Treatment
- Calpain Protease Function and Regulation
- Adipokines, Inflammation, and Metabolic Diseases
- Physical Activity and Health
- Coenzyme Q10 studies and effects
- Cardiac Ischemia and Reperfusion
University of Brescia
2015-2024
Brescia University
2010-2024
Universidade Estadual de Campinas (UNICAMP)
2018
University of Parma
2007
RELX Group (Netherlands)
2000
Ospedale di Rivoli
1999
BacKGrOUNd: intestinal dysbiosis has been proposed as a possible contributor of the development type 2 diabetes (T2d).indeed, commensal fungi and opportunistic bacteria stimulate local immune system, altering permeability with consequent leaky gut, which in turn activates systemic inflammation responsible for insulin resistance.It is also well known that chronic exercise improves glucose control diabetes-induced damage.The aim this study was to evaluate role on gut flora composition T2D...
Background: Many patients who have been suffering by C ovid -19 suffer of long-C syndrome, with symptoms fatigue and muscular weakness that characterize post-acute sequelae SARS-CoV-2 infection (PASC). However, there is limited knowledge about the molecular pathophysiology, serum profile these patients. Methods: We studied blood 75 selected patients, previous confirmed -19, 2 months after hospital discharge, reported new-onset fatigue, muscle and/or dyspnea not present prior to virus...
Carfilzomib (CFZ) is a new proteasome inhibitor used for the treatment of multiple myeloma. Besides heart failure, angina and myocardial ischemia occurred following administration CFZ, which not contraindicated in patients with recent infarction/unstable excluded from safety trials.To test effects CFZ (10-9 to 10-7mol/L) on vascular tone reactivity isolated rabbit aorta.CFZ administered by bolus injection increased coronary perfusion pressure (CPP) at all tested concentrations mildly raised...
Cancer cells require both energy and material to survive duplicate in a competitive environment. Nutrients, such as amino acids (AAs), are not only caloric source, but can also modulate cell metabolism modify hormone homeostasis. Our hypothesis is that the environmental messages provided by AAs rule dynamics of cancer life or death, alteration balance between essential (EAAs) non-essential (NEAAs) (lower higher than 50%, respectively) present nutrients may represent key instrument alter...
BACKGROUND:Although originally described as a survival mechanism, it is unknown whether and to what extent autophagy implicated in the terminal stages of heart failure. Here, we studied magnitude evolution patients with intractable MATERIAL AND METHODS:Myocardial samples were obtained from 22 ischemic cardiomyopathy idiopathic dilated who undergoing cardiac transplantation. Hearts 11 died non-cardiac causes used control samples. Autophagy was evaluated by immunostaining monoclonal...
An adequate intake of essential (EAA) and non-essential amino acids (NEAA) is crucial to preserve cell integrity whole-body metabolism. EAA introduced with diet may be insufficient meet the organismal needs, especially under increased physiological requirements or in pathological conditions, condition lifespan. We therefore examined effects iso-caloric providing same nitrogenous content diets, any containing different stoichiometric blends EAA/NEAA, on mouse Three groups just-weaned male...
Klotho proteins (α- and β) are membrane-based circulating that regulate cell metabolism, as well the lifespan modulating activity of Fibroblast Growth Factors (FGFs). Recent data has shown higher plasma levels reduce cardiovascular risk, suggesting a protective role in diseases. However, although so far it been identified various organs, is unknown whether cardiomyocytes express FGFs, high risk could affect cardiac expression Klotho, FGFs other molecules.We selected 20 patients with an...
Chronic alcohol consumption promotes mitochondrial dysfunction, oxidative stress, defective protein metabolism, and fat accumulation in hepatocytes (liver steatosis). Inadequate amino acid metabolism is worsened by malnutrition, frequently present alcohol-consuming patients, with reduced circulating branched-chain acids (BCAAs). Here we asked whether dietary supplementation a specific mixture, enriched BCAAs (BCAAem) able to promote function muscle of middle-aged rodents, would prevent...
Identifying the molecular mechanisms underlying radioresistance is a priority for treatment of RMS, myogenic tumor accounting approximately 50% all pediatric soft tissue sarcomas. We found that irradiation (IR) transiently increased phosphorylation Akt1, Src, and Cav1 in human RD RH30 lines. Synthetic inhibition Akt1 Src ROS levels RMS lines, promoting cellular radiosensitization. Accordingly, elevated activation Akt1/Src/Cav1 pathway, as detected two lines characterized by overexpression...
Purpose. This paper aims to present a unique perspective that emphasizes the intricate interplay between energy, dietary proteins, and amino acid composition, underscoring their mutual dependence for health-related considerations. Energy protein synthesis are fundamental biological processes, crucial sustenance of life growth organisms. Methods Results. We explore relationship energy metabolism, synthesis, regulatory mechanisms, sources, availability, autophagy, in order elucidate how these...
Doxorubicin (Doxo) is a widely prescribed drug against many malignant cancers. Unfortunately, its utility limited by toxicity, in particular progressive induction of congestive heart failure. Doxo acts primarily as mitochondrial toxin, with consequent increased production reactive oxygen species (ROS) and attendant oxidative stress, which drives cardiac dysfunction cell death. A diet containing special mixture all essential amino acids (EAAs) has been shown to increase mitochondriogenesis,...
We have re‐evaluated, using the anterograde tracer biocytin, supraspinal efferent projections from parabrachial complex (PBN) to gain new information about nature of its connections and nerve terminal patterns. selectively injected biocytin into 3 main regions nucleus (lateral PBN, medial PBN Kölliker‐Fuse nucleus). observed distinct groups ascending descending fibres different calibre running throughout brain reaching many areas involved in regulation autonomic function. Here we detected...
Patients with metabolic syndrome (MetS) have an increased risk of cardiovascular disease. Data obtained from muscle biopsies demonstrated altered insulin signaling (IS) in patients MetS. The IS regulates critical cell functions including molecular-regulated cellular metabolite fluxes, protein and energetic metabolism, proliferation apoptosis consequent regulation life endothelial homeostasis blood coagulation. However, little is known about MetS patients. aim this study was to develop a...
Aims: Myopathy, characterized by mitochondrial oxidative stress, occurs in ∼10% of statin-treated patients, and a major risk exists with potent statins such as rosuvastatin (Rvs). We sought to determine whether peculiar branched-chain amino acid-enriched mixture (BCAAem), found improve function reduce stress muscle middle-aged mice, was able prevent Rvs myopathy. Results: Dietary supplementation BCAAem the structural functional alterations induced young mice. Rvs-increased plasma...