A5030128394- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Regulation of Appetite and Obesity
- Cardiovascular Disease and Adiposity
- Diet and metabolism studies
- Biochemical Analysis and Sensing Techniques
- Antibiotic Resistance in Bacteria
- Antibiotics Pharmacokinetics and Efficacy
- Metabolism and Genetic Disorders
- Neurogenesis and neuroplasticity mechanisms
- Diet, Metabolism, and Disease
- Pancreatic function and diabetes
- Exercise and Physiological Responses
- MicroRNA in disease regulation
- Neuroendocrine regulation and behavior
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Eating Disorders and Behaviors
- Cancer, Hypoxia, and Metabolism
- Liver Disease Diagnosis and Treatment
- Endoplasmic Reticulum Stress and Disease
- Lipid metabolism and biosynthesis
- Circadian rhythm and melatonin
- Sleep and Wakefulness Research
- Cancer Cells and Metastasis
- Mesenchymal stem cell research
Temple University
2009-2025
Istituto Nazionale di Riposo e Cura per Anziani
2025
Istituti di Ricovero e Cura a Carattere Scientifico
2025
University of Siena
2013-2025
Marche Polytechnic University
2015-2024
Thomas Jefferson University Hospital
2024
Ospedali Riuniti di Ancona
1995-2022
Azienda Ospedaliero Universitaria Ospedali Riuniti
2022
Sapienza University of Rome
2002-2016
Policlinico Umberto I
2012-2016
We previously suggested that, in obese animals and humans, white adipose tissue inflammation results from the death of hypertrophic adipocytes; these are then cleared by macrophages, giving rise to distinctive structures we denominated crown-like structures. Here present evidence that subcutaneous visceral adipocytes leptin-deficient (ob/ob db/db) mice exhibit ultrastructural abnormalities (including calcium accumulation cholesterol crystals), many which more common hyperglycemic db/db...
Abstract Aims Human epicardial adipose tissue (EAT) plays a crucial role in the development and progression of coronary artery disease, atrial fibrillation, heart failure. Microscopically, EAT is composed adipocytes, nerve tissues, inflammatory, stromovascular, immune cells. Epicardial white tissue, albeit it also has brown fat-like or beige features. No muscle fascia divides myocardium; this allows direct interaction crosstalk between fat myocardium. Thus, might be therapeutic target for...
The mammalian adipose organ is composed of subcutaneous and visceral depots containing white brown adipocytes. Cold acclimatisation induces an increase in the component without affecting overall number adipocytes; this form plasticity associated to obesity diabetes resistance experimental models. activates drive sympathetic nervous system organ, where vast majority nerve fibers are fact noradrenergic. However, it unclear whether how such involved plastic changes organ. We thus conducted a...
Converging evidence indicates that white adipose tissue (WAT) is innervated by the sympathetic nervous system (SNS) based on immunohistochemical labeling of a SNS marker (tyrosine hydroxylase [TH]), tract tracing WAT postganglionic innervation, pseudorabies virus (PRV) transneuronal outflow neurons, and functional from denervation studies. Recently, para-SNS (PSNS) innervation was suggested because local surgical sympathectomy (sparing hypothesized parasympathetic innervation) followed PRV...
Dysregulated adipocyte physiology leads to imbalanced energy storage, obesity, and associated diseases, imposing a costly burden on current health care. Cannabinoid receptor type-1 (CB1) plays crucial role in controlling metabolism through central peripheral mechanisms. In this work, adipocyte-specific inducible deletion of the CB1 gene (Ati-CB1–KO) was sufficient protect adult mice from diet-induced obesity metabolic alterations reverse phenotype already obese mice. Compared with controls,...
Parkinson is a common neurodegenerative disorder, characterized by motor and non-motor symptoms, including abnormalities in the gut function, which may appear before sign.To date, there are treatments that can help relieve Parkinson' disease (PD)-associated but no cure to control onset progression of this disorder.Altered components could represent key role gutbrain axis, bidirectional system between central nervous enteric system.Diet alter microbiota composition, affecting gut-brain axis...
High-fat diet (HFD) consumption leads to obesity and a chronic state of low-grade inflammation, named metainflammation. Notably, metainflammation contributes neuroinflammation due the increased levels circulating free fatty acids cytokines. It indicates strict interplay between peripheral central counterparts in pathogenic mechanisms obesity-related mood disorders. In this context, impairment internal hypothalamic circuitry runs tandem with alteration other brain areas associated emotional...
Abstract Obesity is a major risk factor for type 2 diabetes and trigger of chronic systemic inflammation. Recent evidence suggests that an increased burden senescent cells (SCs) in the adipose tissue obese/diabetic animal models might underlie such pro-inflammatory phenotype. However, role macrophages as candidate SCs, their phenotype, distribution SCs among fat depots, clinical relevance are debated. The senescence marker β-galactosidase macrophage CD68 were scored visceral (vWAT)...
Mammalian breast adipose tissue is replaced by a milk-secreting gland during pregnancy; the reverse process takes place upon interruption of lactation. Morphological and bromodeoxyuridine studies provide indirect evidence that mouse mammary adipocytes transform into secretory epithelial cells pregnancy revert to after By using Cre-loxP recombination system we show whey acidic protein (WAP)- Cre / R26R mice, in which express lacZ gene pregnancy, contains labeled involution. Conversely,...
Functional and histological evidence for the sympathetic nervous system (SNS) innervation of white adipose tissue (WAT) exists several species; however, its sensory has only been shown in laboratory rats, function is unclear. We tested effects SNS Siberian hamster epididymal inguinal WAT (EWAT IWAT) by assessing calcitonin gene-related peptide (CGRP)- tyrosine hydroxylase-immunoreactivity (ir), respectively. Next, we role on growth cellularity because surgical denervation increases pad mass...
Non-Alcoholic Fatty Liver Disease (NAFLD) represents the most common form of chronic liver injury and can progress to cirrhosis hepatocellular carcinoma. A "multi-hit" theory, involving high fat diet signals from gut-liver axis, has been hypothesized. The role NLRP3-inflammasome, which senses dangerous signals, is controversial. Nlrp3-/- wild-type mice were fed a Western-lifestyle with fructose in drinking water (HFHC) or chow diet. Nlrp3-/--HFHC showed higher hepatic expression PPAR γ2...
Obesity results from critical periods of positive energy balance characterized by caloric intake greater than expenditure. This disbalance promotes adipose tissue dysfunction which is related to other comorbidities. Melatonin a low-cost therapeutic agent and studies indicate that its use may improve obesity-related disorders. To evaluate if the melatonin efficient in delaying or even blocking damages caused excessive ingestion high-fat diet (HFD) mice, as well improving inflammatory profile...
Severe quantitative and qualitative brown adipocyte defects are common in obesity. To investigate whether aberrant expression of tumor necrosis factor alpha (TNF-alpha) obesity is involved functional fat atrophy, we have studied genetically obese (ob/ob) mice with targeted null mutations the genes encoding two TNF receptors. The absence both receptors or p55 receptor alone resulted a significant reduction apoptosis an increase beta(3)-adrenoreceptor uncoupling protein-1 mice. Increased...