A5012762049- Effects and risks of endocrine disrupting chemicals
- Liver Disease Diagnosis and Treatment
- Cannabis and Cannabinoid Research
- Tryptophan and brain disorders
- Diet and metabolism studies
- Gut microbiota and health
- Peroxisome Proliferator-Activated Receptors
- Circadian rhythm and melatonin
- Diet, Metabolism, and Disease
- Adipose Tissue and Metabolism
- Parkinson's Disease Mechanisms and Treatments
- Regulation of Appetite and Obesity
- Neurological diseases and metabolism
- Ginger and Zingiberaceae research
- Neurogenesis and neuroplasticity mechanisms
- Lipid metabolism and biosynthesis
- Epilepsy research and treatment
- Dietary Effects on Health
- Telomeres, Telomerase, and Senescence
- Biochemical effects in animals
- Acute Kidney Injury Research
- Stress Responses and Cortisol
- Electrical and Bioimpedance Tomography
- Magnetic Field Sensors Techniques
- Vitamin D Research Studies
University of Naples Federico II
2019-2024
Karolinska Institutet
2023-2024
National Institutes of Health
2020
Yale University
2020
Harvard University
2020
Rockefeller University
2020
Brain mitochondrial dysfunction is involved in the development of neurological and neurodegenerative diseases. Mitochondria specifically located at synapses play a key role providing energy to support synaptic functions plasticity, thus their defects may lead failure, which common hallmark High-Fat Diet (HFD) consumption increases brain oxidative stress impairs functions, although underlying mechanisms are not completely understood. The aim our study analyze neuroinflammation dysfunctions...
High-fat diet (HFD) consumption leads to obesity and a chronic state of low-grade inflammation, named metainflammation. Notably, metainflammation contributes neuroinflammation due the increased levels circulating free fatty acids cytokines. It indicates strict interplay between peripheral central counterparts in pathogenic mechanisms obesity-related mood disorders. In this context, impairment internal hypothalamic circuitry runs tandem with alteration other brain areas associated emotional...
Obesity is associated with gastrointestinal (GI) tract and central nervous system (CNS) disorders. High-fat diet (HFD) feeding-induced obesity in mice induces dysbiosis, causing a shift toward bacteria-derived metabolites detrimental effects on metabolism inflammation: events often contributing to the onset progression of both GI CNS Palmitoylethanolamide (PEA) an endogenous lipid mediator beneficial mouse models However, mechanisms underlining its enteroprotective neuroprotective still need...
Abstract Sodium valproate (VPA), an antiepileptic drug, may cause dose‐ and time‐dependent hepatotoxicity. However, its iatrogenic molecular mechanism the rescue therapy are disregarded. Recently, it has been demonstrated that sodium butyrate (NaB) reduces hepatic steatosis, improving respiratory capacity mitochondrial dysfunction in obese mice. Here, we investigated protective effect of NaB counteracting VPA‐induced hepatotoxicity using vitro vivo models. Human HepG2 cells primary rat...
Chronic kidney disease (CKD) development after acute injury (AKI) involves multiple mechanisms, including inflammation, epithelial-mesenchymal transition (EMT), and extracellular matrix deposition, leading to progressive tubulointerstitial fibrosis. Recently, a central role for peroxisome-proliferator activated receptor (PPAR)-α has been addressed in preserving function during AKI. Among endogenous lipid mediators, oleoylethanolamide (OEA), PPAR-α agonist, studied its metabolic...
Abstract Peroxisome proliferator‐activated receptor (PPAR)‐α activation controls hepatic lipid homeostasis, stimulating fatty acid oxidation, and adapting the metabolic response to overload storage. Here, we investigate effect of palmitoylethanolamide (PEA), an endogenous PPAR‐α ligand, in counteracting inflexibility mitochondrial dysfunction induced by high‐fat diet (HFD) mice. Long‐term PEA administration (30 mg/kg/die per os ) HFD mice limited accumulation, increased energy expenditure,...
Lines of evidence have shown the embryogenic and transgenerational impact bisphenol A (BPA), an endocrine-disrupting chemical, on immune-metabolic alterations, inflammation, oxidative stress, while BPA toxic effects in adult obese mice are still overlooked. Here, we evaluate BPA’s worsening effect several hepatic maladaptive processes associated to high-fat diet (HFD)-induced obesity mice. After 12 weeks HFD feeding, C57Bl/6J male were exposed daily (50 μg/kg per os) along with for 3 weeks....
The potential role of brown and beige adipose tissue against obesity has been recognized. Browning, or beiging white (WAT) is associated with the remodeling adipocytes improvement their metabolic secretory functions. Here, palmitoylethanolamide (PEA) restore plasticity impaired in mice on a high-fat diet (HFD). Young male C57Bl/6J were fed control (STD) HFD for 12 weeks. Ultramicronized PEA (30 mg/kg/die p.o.) was administered an additional 7 weeks, together HFD. recovered interscapular fat...
Background and Purpose High‐fat diet (HFD)‐induced obesity is accompanied by metabolic neurochemical changes that have been associated with depression. Recent studies indicate palmitoylethanolamide (PEA) exerts effects holds neuroprotective potential. However, on HFD exposure in mice which investigate the of PEA monoamine system synaptic plasticity are limited. Experimental Approach In C57Bl/6J male mice, was established feeding for 12 weeks. Then, were treated ultra‐micronized (30 mg·kg −1...
Abstract The use/misuse of antibiotics leads to pathological features referring antibiotic-induced intestinal injury (AIJ), a clinical issue that plays prominent role in the development severe digestive disturbances. AIJ is characterized by loss architecture and function, dysbiosis bacterial translocation into liver, triggering hepatic inflammation. This study aimed at determining beneficial effect N-(1-carbamoyl-2-phenylethyl) butyramide (FBA), butyrate releasing compound,...
The antibiotic-induced intestinal injury (AIJ) is associated with diarrhoea and gastrointestinal discomfort. However, the pathological mechanisms related side effects antibiotic use/misuse may be counteracted by probiotics. This study aims to evaluate effect protective of a probiotic formulation containing Alkalihalobacillus clausii (formerly Bacillus clausii; BC) spores in an experimental model AIJ. C57/Bl6J mice were orally challenged high dose ceftriaxone for five days along BC treatment...
Orexin A (OxA) is a neuropeptide produced in the lateral hypothalamus that performs pleiotropic functions different tissues, including involvement energy homeostasis and reproductive neuroendocrine functions. The role of OxA particularly important given well-studied relationships between physiological mechanisms controlling balance reproduction. enzyme P450 aromatase (ARO) helps convert androgens to estrogens has roles steroidogenesis, spermatogenesis, metabolism several organs. goal this...
The increased burden of senescent cells is as a well-established hallmark aging and age-related diseases. This finding sparked significant interest in the identification molecules capable selectively eliminating cells, so-called senolytics. Here, we fine-tuned method for senolytics that compatible with high-content fluorescence microscopy. We used spectral detector imaging to measure emission spectrum unlabeled control or cells. observed exhibited higher levels autofluorescence than their...
N-acylethanolamines (NAEs) are endogenous lipid-signalling molecules involved in inflammation and energy metabolism. The potential pharmacological effect of NAE association managing inflammation-based metabolic disorders is unexplored. To date, targeting liver-adipose axis can be considered a therapeutic approach for the treatment obesity related dysfunctions. Here, we investigated OLALIAMID® (OLA), an olive oil-derived mixture, limiting liver adipose tissue (AT) dysfunction high-fat diet...
Abstract Background It is well known that high-fat diet (HFD) feeding causes cardiac inflammation, remodeling, and dysfunction, increased fat intake, especially saturated fat, a major driver of cardiometabolic diseases. Oleoylethanolamide (OEA) member acylethanolamides recognized for its metabolic anti-inflammatory properties due to the high affinity different receptors role as modulator endocannabinoid system. OEA effects on cardiovascular alterations caused by overnutrition are still...
Bisphenol A (BPA) is an endocrine-disrupting chemical inducing several damages such as neurotoxicity, immunotoxicity, and metabolic disorders. Obesity the main risk factor for increased occurrence of alterations well mood Here, we investigated in obese mice effects BPA on anxiety-like behavior, associated with neuroinflammation immune activation. Male 6 weeks-old C57Bl/6J were divided into 4 groups: (I) control group (STD) receiving chow diet vehicle; (II) STD treated (50 μg/kg/die); (III)...