A5038838789- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Regulation of Appetite and Obesity
- COVID-19 Clinical Research Studies
- COVID-19 and healthcare impacts
- Cardiovascular Disease and Adiposity
- Diet and metabolism studies
- Cutaneous Melanoma Detection and Management
- Peroxisome Proliferator-Activated Receptors
- Biochemical Analysis and Sensing Techniques
- Cholinesterase and Neurodegenerative Diseases
- Apelin-related biomedical research
- Sirtuins and Resveratrol in Medicine
- Long-Term Effects of COVID-19
- Pancreatic function and diabetes
- Alzheimer's disease research and treatments
- RNA modifications and cancer
- Telomeres, Telomerase, and Senescence
- Epigenetics and DNA Methylation
- Medicinal Plants and Neuroprotection
- Immunotherapy and Immune Responses
- Thermal Regulation in Medicine
Marche Polytechnic University
2019-2023
Abstract Obesity is a major risk factor for type 2 diabetes and trigger of chronic systemic inflammation. Recent evidence suggests that an increased burden senescent cells (SCs) in the adipose tissue obese/diabetic animal models might underlie such pro-inflammatory phenotype. However, role macrophages as candidate SCs, their phenotype, distribution SCs among fat depots, clinical relevance are debated. The senescence marker β-galactosidase macrophage CD68 were scored visceral (vWAT)...
Administration of ciliary neurotrophic factor (CNTF) to experimental animals exerts anti-obesity effects by acting on multiple targets. In white adipose tissue CNTF reduces lipid content, promotes fatty acid (FA) oxidation and improves insulin sensitivity. This study was performed establish whether similar human adipocytes. To this end, differentiation induced in vitro multipotent adipose-derived stem (hMADS) cells. receptor α (CNTFRα) expression assessed hMADS cells adipocytes qRT-PCR,...
Abstract In the last decades, concept of adipose organ has emerged, giving tissue an active endocrine and immunologic function through secretion multiple cytokines chemokines that seem to be implicated in development progression several cancer, including cutaneous melanoma. this pilot experimental study, we analyzed expression peritumor subcutaneous most significant adipokines involved processes carcinogenesis metastasis a population melanoma patients two control groups composed melanocytic...
In humans and experimental animals, the administration of ciliary neurotrophic factor (CNTF) reduces food intake body weight. To gain further insights into mechanism(s) underlying its satiety effect, we: (i) evaluated CNTF-dependent activation Janus kinase 2 (JAK2) signal transducer activator transcription 3 (STAT3) pathway in mouse models where neuropeptide Y (NPY) pro-opiomelanocortin (POMC) neurons can be identified by green fluorescent protein (GFP); (ii) assessed whether CNTF promotes...
To establish whether obesity involves activation of endogenous ciliary neurotrophic factor (CNTF) signalling, we evaluated its plasma levels in patients with and correlated values the major clinical haematological indices obesity, insulin resistance systemic inflammation. This study involved 118 subjects: 39 healthy controls (19 men), subjects men) 40 diabetes (20 men). Plasma CNTF receptor α (CNTFRα) were measured using commercial ELISA kits. The results showed that was significantly higher...
Background: Peripheral alterations of mitochondrial DNA copy number (mtDNAcn) in obesity and associated co-morbidities have been previously shown. Furthermore, the possibility that methylation could occur mtDNA (in particular displacement loop, D-Loop) regulate its functions has raised. However, limited data about adipose tissue are currently available. Since a strict crosstalk between nucleus mitochondria exists, especially terms one-carbon cycle (that supports reactions cell), we...
Abstract Butyrylcholinesterase (BChE) is a hydrolytic enzyme that together with acetylcholinesterase (AChE) belongs to the cholinesterase family. Whereas AChE has well‐established role in regulating cholinergic neurotransmission central and peripheral synapses, physiological of BChE remains elusive. In this morphological immunohistochemical double‐label confocal microscopy study we investigated distribution mouse gastrointestinal tract. BChE‐positive cells were detected liver (both...
Since white adipose tissue (WAT) lacks parasympathetic cholinergic innervation, the source of acetylcholine (ACh) acting on adipocyte receptors is unknown. This study was designed to identify ACh-producing cells in mouse and human visceral WAT determine whether a non-neuronal system becomes activated obese inflamed WAT. Mouse epididymal (eWAT) omental fat were studied normal subjects. The expression key molecules involved signaling evaluated by qRT-PCR western blotting whereas their...
Abstract Background Visceral obesity is a critical determinant of severe coronavirus disease-2019 (COVID-19). Methods: In this study, we performed comprehensive histomorphologic analysis autoptic visceral adipose tissues (VAT), lungs and livers 19 COVID-19 23 non-COVID-19 subjects. Results Although there were no between-groups differences in body-mass-index adipocytes size, higher prevalence CD68+ macrophages subjects’ VAT was detected (p=0.005) accompanied by crown-like structures presence,...