A5023784068- Diet and metabolism studies
- Epigenetics and DNA Methylation
- Fatty Acid Research and Health
- Nutrition, Genetics, and Disease
- Mitochondrial Function and Pathology
- Metabolism and Genetic Disorders
- Biochemical effects in animals
- Milk Quality and Mastitis in Dairy Cows
- MicroRNA in disease regulation
- Protein Hydrolysis and Bioactive Peptides
- Traditional Chinese Medicine Analysis
- Health, Environment, Cognitive Aging
- Meat and Animal Product Quality
- GDF15 and Related Biomarkers
- Probiotics and Fermented Foods
- Gut microbiota and health
- RNA modifications and cancer
- Identification and Quantification in Food
- Apelin-related biomedical research
- Birth, Development, and Health
- Nuclear Receptors and Signaling
- Pharmacological Effects of Natural Compounds
- Autophagy in Disease and Therapy
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer-related molecular mechanisms research
Università di Camerino
2020-2025
Centro San Giovanni di Dio Fatebenefratelli
2025
Among cardiovascular disease (CVD) biomarkers, the mitochondrial DNA copy number (mtDNAcn) is a promising candidate. A growing attention has been also dedicated to trimethylamine-N-oxide (TMAO), an oxidative derivative of gut metabolite trimethylamine (TMA). With aim identify biomarkers predictive CVD, we investigated TMA, TMAO, and mtDNAcn in population 389 coronary artery (CAD) patients 151 healthy controls, association with established risk factors for CVD (sex, age, hypertension,...
Mitochondrial DNA copy number (mtDNAcn) has been proposed for use as a surrogate biomarker of mitochondrial health, and evidence suggests that mtDNA might be methylated. Intermediates the one-carbon cycle (1CC), which is duplicated in cytoplasm mitochondria, have major role modulating impact diet on epigenome. Moreover, epigenetic pathways redox system are linked by metabolism glutathione (GSH). In cohort 101 normal-weight 97 overweight/obese subjects, we evaluated mtDNAcn methylation levels...
Trimethylamine (TMA), a byproduct of gut microbiota metabolism from dietary precursors, is not only the precursor trimethylamine-N-oxide (TMAO) but may also affect health. An in vitro model intestinal epithelium Caco-2 cells was used to evaluate impact TMA on inflammation, paracellular permeability, epigenetics and mitochondrial functions. The expression levels pro-inflammatory cytokines (IL-6, IL-1β) increased significantly after 24 h exposure 1 mM. associated with an upregulation SIRT1...
Mitochondrial DNA copy number (mtDNAcn) and its methylation level in the D-loop area have been correlated with metabolic health are suggested to vary response environmental stimuli, including diet. Circulating levels of trimethylamine-n-oxide (TMAO), which is an oxidative derivative trimethylamine (TMA) produced by gut microbiome from dietary precursors, associated chronic diseases impact on mitochondrial dynamics. This study aimed investigate relationship between diet, TMA, TMAO, mtDNAcn,...
Background: Peripheral alterations of mitochondrial DNA copy number (mtDNAcn) in obesity and associated co-morbidities have been previously shown. Furthermore, the possibility that methylation could occur mtDNA (in particular displacement loop, D-Loop) regulate its functions has raised. However, limited data about adipose tissue are currently available. Since a strict crosstalk between nucleus mitochondria exists, especially terms one-carbon cycle (that supports reactions cell), we...
Intramammary gland infections can affect milk quality, with changes in composition, biochemical characteristics, and antioxidant properties. Total bacterial count (TBC) somatic cell (SCC) are key determinants to define the appropriate quality of raw must meet specific requirements established by European regulation. Our interest was examine if microbiological safety window may hide differences regarding nutritional value approved for commercialization. Therefore, we investigated microRNA...
BACKGROUND: Changes in DNA methylation along the life have been documented, and environmental exposures (including diet, physical activity smoking) can accelerate or decelerate this process. The epigenetic clock estimates biological age of an individual measuring patterns specific areas its genome. Recently, a new based on 6 CpGs has proposed, with high potential to become easy accessible tool able measure (EA) individual. OBJECTIVES: This study aims validate CpG comparing it other...
ABSTRACT Among cardiovascular disease (CVD) biomarkers, the mitochondrial DNA copy number (mtDNAcn) is a promising candidate. A growing attention has been also dedicated to trimethylamine-N-oxide (TMAO), an oxidative derivative of gut metabolite trimethylamine (TMA). With aim identify biomarkers predictive CVD, we investigated TMA, TMAO and mtDNAcn in population 389 coronary artery (CAD) patients 151 healthy controls, association with established risk factors for CVD (gender, age,...