A5047193302- Adipose Tissue and Metabolism
- Cardiovascular Disease and Adiposity
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Diet and metabolism studies
- Regulation of Appetite and Obesity
- Single-cell and spatial transcriptomics
- Urticaria and Related Conditions
- Exercise and Physiological Responses
- Eosinophilic Disorders and Syndromes
- COVID-19 Clinical Research Studies
- Biochemical Analysis and Sensing Techniques
- Vasculitis and related conditions
- Circadian rhythm and melatonin
- Lymphatic System and Diseases
- Thermal Regulation in Medicine
- Long-Term Effects of COVID-19
- Body Contouring and Surgery
- Bariatric Surgery and Outcomes
- Sleep and Wakefulness Research
- Eosinophilic Esophagitis
- Diabetes Treatment and Management
- COVID-19 and healthcare impacts
Marche Polytechnic University
2019-2025
Abstract Aims Human epicardial adipose tissue (EAT) plays a crucial role in the development and progression of coronary artery disease, atrial fibrillation, heart failure. Microscopically, EAT is composed adipocytes, nerve tissues, inflammatory, stromovascular, immune cells. Epicardial white tissue, albeit it also has brown fat-like or beige features. No muscle fascia divides myocardium; this allows direct interaction crosstalk between fat myocardium. Thus, might be therapeutic target for...
Obesity is the fifth leading cause of death worldwide. In mice and humans with obesity, adipose organ undergoes remarkable morpho-functional alterations. The comprehension function organization paramount importance to understand its pathology formulate future therapeutic strategies. present study, we performed anatomical dissections, magnetic resonance imaging, computed axial tomography histological immunohistochemical assessments mouse tissues. We demonstrate that most two types tissues...
Abstract Objective This study aimed to evaluate adipose tissue of lipedema patients. Methods Gluteo‐femoral (affected area) and interscapular (nonaffected from 10 lean patients affected by stage 1 2 was studied compared with obesity 12 Results The main features were alterations capillaries wall thickening ( p ≤ 0.0001), endothelial pericyte hyperplasia = 0.03 0.004), hypodense areas in basal membrane, degeneration exfoliation degenerated cells into the capillary lumen. Adipocytes larger...
Hypothalamic dysfunction is an initial event following diet-induced obesity, primarily involving areas regulating energy balance such as arcuate nucleus (Arc) and median eminence (ME). To gain insights into the early hypothalamic alterations, adult CD1 mice fed a high-fat diet (HFD) for 6 weeks were studied compared with normo-fed controls. Transmission scanning electron microscopy histological staining employed morphological studies of ME, while Raman spectroscopy was applied biochemical...
The pathogenic role of p-ANCA in eosinophilic granulomatosis with polyangiitis (EGPA) is a long-standing matter debate. In this work, we report our real-life experience EGPA patients, treated biologics targeting type 2 (T2)-eosinophilic inflammation (Mepolizumab, Benralizumab, Dupilumab). Interestingly, observed extrarespiratory relapses only p-ANCA-positive patients (2/5 cutaneous vasculitis, 3/5 constitutional symptoms), new rise and normal eosinophil blood count. Notably, revising cohort...
Abstract Background Visceral obesity is a critical determinant of severe coronavirus disease-2019 (COVID-19). Methods: In this study, we performed comprehensive histomorphologic analysis autoptic visceral adipose tissues (VAT), lungs and livers 19 COVID-19 23 non-COVID-19 subjects. Results Although there were no between-groups differences in body-mass-index adipocytes size, higher prevalence CD68+ macrophages subjects’ VAT was detected (p=0.005) accompanied by crown-like structures presence,...
ABSTRACT White adipose tissue (WAT), once regarded as morphologically and functionally bland, is now recognized to be dynamic, plastic, heterogenous, involved in a wide array of biological processes including energy homeostasis, glucose lipid handling, blood pressure control, host defense 1 . High fat feeding other metabolic stressors cause dramatic changes morphology, physiology, cellular composition , alterations adiposity are associated with insulin resistance, dyslipidemia, type 2...
Abstract Purpose The visceral fat of patients affected by abdominal obesity is inflamed, and the main histopathologic feature high density crown-like structures (CLS). Epicardial adipose tissue (EAT) a paramount importance for its relationships with coronary vessels myocardium. Its inflammation in could be clinical relevance, but histopathological studies on CLS EAT are lacking. This study aimed to assess histopathology biopsies obtained from undergoing open-heart surgery. Methods We...