Gianluca Moroncini
A5028698640- Systemic Sclerosis and Related Diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Dermatologic Treatments and Research
- Inflammatory Myopathies and Dermatomyositis
- Eosinophilic Disorders and Syndromes
- Mast cells and histamine
- Autoimmune Bullous Skin Diseases
- COVID-19 Clinical Research Studies
- Systemic Lupus Erythematosus Research
- Immunodeficiency and Autoimmune Disorders
- Urticaria and Related Conditions
- Long-Term Effects of COVID-19
- Skin Diseases and Diabetes
- Rheumatoid Arthritis Research and Therapies
- Diagnosis and Treatment of Venous Diseases
- Vasculitis and related conditions
- Viral Infections and Immunology Research
- Emergency and Acute Care Studies
- Heart Failure Treatment and Management
- Venous Thromboembolism Diagnosis and Management
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Psoriasis: Treatment and Pathogenesis
- Spondyloarthritis Studies and Treatments
- Prion Diseases and Protein Misfolding
- Eosinophilic Esophagitis
Marche Polytechnic University
2016-2025
University of Palermo
2023-2024
Ospedali Riuniti di Ancona
2001-2023
Jichi Medical University
2023
Turku University Hospital
2023
Oulu University Hospital
2023
University Hospital of Zurich
2023
NIHR Leeds Musculoskeletal Biomedical Research Unit
2023
Azienda Ospedaliero Universitaria Ospedali Riuniti
2014-2022
Ospedali Riuniti Marche Nord
2022
Pulmonary involvement represents a major cause of death systemic sclerosis (SSc) patients. Recent data suggest that tyrosine kinase inhibitors, such as imatinib, may be therapeutic option for SSc However, preliminary published clinical trials were inconclusive about imatinib efficacy and showed side effects. The purpose this study was to verify tolerability low-dose on interstitial lung disease in cohort patients unresponsive cyclophosphamide therapy.Thirty consecutive with active pulmonary...
Digital ulcers (DUs) are a rather frequent and invalidating complication in systemic sclerosis (SSc), often showing very slow or null tendency to heal, spite of the commonly used local therapeutic procedures. Recently, stem cell therapy has emerged as new approach accelerate wound healing. In present study, we have tentatively treated long-lasting poorly responsive traditional SSc-related DUs by implantation autologous adipose tissue-derived (ATDC) fractions. Fifteen patients with SSc having...
Systemic sclerosis (SSc) is an autoimmune disease characterized by extensive visceral organ and skin fibrosis. SSc patients have increased production of autoreactive antibodies Wnt signaling activity. We found that expression the gene encoding inhibitor factor 1 (WIF-1) was decreased in fibroblasts from patient biopsies. WIF-1 deficiency cells correlated with abundance effector β-catenin collagen. Knocking down normal collagen production. loss DNA damage were induced either immunoglobulins...
Introduction Nintedanib (NTD) has been shown to be effective in systemic sclerosis (SSc)-interstitial lung disease (ILD). Here we describe the efficacy and safety of NTD a real-life setting. Methods Patients with SSc-ILD treated were retrospectively evaluated at 12 months prior introduction; baseline after introduction. The following parameters recorded: SSc clinical features, tolerability, pulmonary function tests modified Rodnan skin score (mRSS). Results 90 patients (65% female, mean age...
Prion diseases are closely associated with the conversion of cellular prion protein (PrP C ) to an abnormal conformer Sc [Prusiner, S. B. (1998) Proc. Natl. Acad. Sci. USA 95, 13363–13383]. Monoclonal antibodies that bind epitopes comprising residues 96–104 and 133–158 PrP potently inhibit this process, presumably by preventing heterodimeric association , suggest these regions may be critical components –PrP replicative interface. We reasoned transplanting sequence corresponding into a...
Objective Reactive oxygen species (ROS) contribute to the pathogenesis of fibrosis in systemic sclerosis (SSc; scleroderma), and NADPH oxidase (NOX) is an important source ROS. Since role single NOX isoforms has not been previously investigated SSc, this study was undertaken assess expression SSc fibroblasts compared normal healthy cells analyze their cell activation. Methods Expression dermal from patients with control subjects analyzed by real‐time polymerase chain reaction,...
Systemic sclerosis (SSc) and rheumatoid arthritis (RA) are autoimmune diseases that have similar clinical immunologic characteristics. To date, several shared SSc-RA genetic loci been identified independently. The aim of the current study was to systematically search for new common through an interdisease meta-genome-wide association (meta-GWAS) strategy.The designed as a meta-analysis combining GWAS data sets patients with SSc RA, using strategy allowed identification both same-direction...
Objective The greatest genetic effect reported for systemic sclerosis (SSc) lies in the major histocompatibility complex (MHC) locus. Leveraging largest SSc genome-wide association study, we aimed to fine-map this region identify novel human leucocyte antigen (HLA) variants associated with susceptibility and its main clinical serological subtypes. Methods 9095 patients 17 584 controls genotyped were used impute test single-nucleotide polymorphisms (SNPs) across MHC, classical HLA alleles...
To characterize patients with positive anti-topoisomerase I (ATA) in lcSSc.SSc enrolled the EUSTAR cohort a disease duration of ≤3 years at database entry were considered. We assessed risk major organ involvement following groups: ATA-lcSSc vs ACA-lcSSc and ANA without specificity (ANA)-lcSSc, ATA-dcSSc. Cox regression models time-dependent covariates performed outcomes: new-onset interstitial lung (ILD), ILD progression [forced vital capacity (FVC) decline ≥10% ≥5% values diagnosis),...
Background: Endothelial dysfunction has a role in acute COVID-19, contributing to systemic inflammatory syndrome, respiratory distress and vascular events. Evidence regarding COVID-19 middle- long-term consequences on endothelium are still lacking. Our study aimed evaluate if severity could significantly affect the endothelial function after three months from phase. Methods: We assessed outpatients with previous negative SARS-CoV-2 molecular test by measuring flow-mediated dilation (FMD)...
Systemic sclerosis (SSc) sine scleroderma (ssSSc) is a subset of SSc defined by the absence skin fibrosis. Little known about natural history and manifestations among patients with ssSSc.
Abstract Aims Albeit often asymptomatic, heart involvement in systemic sclerosis (SSc) represents a negative prognostic factor, accounting for nearly one-fourth of all deaths. Global longitudinal strain (GLS) is accurate detecting patients with SSc and no overt cardiac disease allows early detection monitoring, but its association clinical endpoints has not been tested so far. The primary outcome was the between left right GLS mortality causes. secondary hospitalizations. Methods results A...
To describe a skin-SCID mouse chimeric model of systemic sclerosis (SSc; scleroderma) fibrosis based on engraftment ex vivo-bioengineered skin using cells derived either from scleroderma patients or healthy donors.Three-dimensional bioengineered containing human keratinocytes and fibroblasts isolated biopsy specimens donors SSc was generated vivo then grafted onto the backs SCID mice. The features grafts were analyzed by immunohistochemistry, functional profile graft defined before after...