A5001193996- Systemic Sclerosis and Related Diseases
- Dermatologic Treatments and Research
- Mesenchymal stem cell research
- Diagnosis and Treatment of Venous Diseases
- Systemic Lupus Erythematosus Research
- Salivary Gland Disorders and Functions
- Connective Tissue Growth Factor Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Lymphatic System and Diseases
- Mast cells and histamine
- Inflammatory Myopathies and Dermatomyositis
- Tissue Engineering and Regenerative Medicine
- Dermatological and Skeletal Disorders
- Body Contouring and Surgery
- Angiogenesis and VEGF in Cancer
- Autoimmune Bullous Skin Diseases
- Kruppel-like factors research
- Hair Growth and Disorders
- Pulmonary Hypertension Research and Treatments
- Autoimmune and Inflammatory Disorders Research
- Fibroblast Growth Factor Research
- Biomarkers in Disease Mechanisms
- Rheumatoid Arthritis Research and Therapies
- Glycosylation and Glycoproteins Research
- Chemokine receptors and signaling
Istituto Ortopedico Gaetano Pini
2011-2021
Scleroderma Foundation
2021
Azienda Socio Sanitaria Territoriale Lariana
2020
University of Milan
2004-2011
Ospedale Maggiore
2004-2005
Istituti di Ricovero e Cura a Carattere Scientifico
2005
Abstract Objective To develop valid instruments for the assessment of disease‐related damage and disease activity in Sjögren's syndrome (SS). Methods Data on 206 patients with primary SS were collected 12 Italian centers. Each patient was scored by 1 investigator, basis a global degree activity. Patients judged to have active at time enrollment underwent second evaluation after 3 months. Univariate multivariate analyses performed select clinical serologic variables that best predictors...
Vascular abnormalities represent the main component of pathobiology systemic sclerosis (SSc), progressing from structural derangements microcirculation with abortive neoangiogenesis to final vessel loss. Since circulating endothelial progenitor cells (EPCs) are important in vascular repair process, we undertook this study examine their numbers peripheral blood (PB) SSc patients and evaluate whether status is related impaired quantitative and/or qualitative aspects bone marrow (BM)...
Digital ulcers (DUs) are a rather frequent and invalidating complication in systemic sclerosis (SSc), often showing very slow or null tendency to heal, spite of the commonly used local therapeutic procedures. Recently, stem cell therapy has emerged as new approach accelerate wound healing. In present study, we have tentatively treated long-lasting poorly responsive traditional SSc-related DUs by implantation autologous adipose tissue-derived (ATDC) fractions. Fifteen patients with SSc having...
Abstract Objective Circulating endothelial cells (CECs) have been described in different conditions involving vascular injury. Vascular abnormalities play a key role the pathogenesis of systemic sclerosis (SSc). The aim this study was to search for presence CECs patients with SSc and evaluate their clinical associations possible pathogenic role. Methods cohort included 46 40 healthy controls. Five‐parameter, 3‐color flow cytometry performed FACScan. were defined as CD45 negative, CD34...
Autologous fat tissue grafting (AFTG) has been successfully used in the treatment of different sclerotic conditions, including localized scleroderma. Patients with advanced systemic sclerosis (SSc)-related perioral thickening and mouth opening limitation are candidates for this therapeutic approach. AFTG lips was performed to improve patients SSc. We enrolled study 20 female diffuse SSc (median age 35 ± 15 years 11 10 disease duration). Two-milliliter fractions autologous drawn from...
A randomized controlled trial (RCT) was performed to confirm preliminary uncontrolled data indicating that regional adipose tissue (AT) grafting (G) is effective in inducing ischemic digital ulcer (IDU) healing patients with systemic sclerosis (SSc). SSc IDUs were be blindly treated AT-G or a sham procedure (SP). consisted of injection, at the base finger IDU, 0.5–1 ml AT after centrifugation fat aspirate. The SP false liposuction and local injection saline solution. primary endpoint compare...
Objective: The prostanoids iloprost and alprostadil are widely used to treat ischaemic changes in patients with Raynaud's phenomenon (RP), but the optimal regimen is poorly defined. We evaluated whether there differences between alprostadil, terms of either clinical efficacy or laboratory data, aim assisting treatment connective tissue disease (CTD)‐associated RP.Methods: Twenty‐one women CTD‐associated RP were given intravenous (11 patients) (10 cyclically (5 consecutive days, followed by 1...
Abstract Introduction Nailfold videocapillaroscopy (NVC) in systemic sclerosis (SSc) is a procedure commonly used for patient classification and subsetting, but not to define disease activity (DA). This study aimed evaluate whether the number of micro-haemorrhages (MHE), micro-thrombosis (MT), giant capillaries (GC), normal/dilated (Cs) NVC could predict DA SSc. Methods Eight-finger was performed 107 patients with SSc, total MHE/MT, GC, mean Cs were counted defined as (NEMO), GC scores,...
Mesenchymal stromal cells (MSCs) have received attention as an ideal source of regenerative because their multipotent differentiation potential. Adipose tissue is attractive MSCs. Recent studies shown that autologous fat grafting may be effective in the treatment systemic sclerosis (SSc), but no specific study exists aimed at investigating whether adipose tissue-derived (ADSCs) from SSc patients maintain normal phenotypic and functional characteristics. The purpose current was to investigate...
Patients with systemic sclerosis (SSc) have significantly fewer and functionally impaired endothelial progenitor cells (EPC) in peripheral blood bone marrow; further, apoptosis seems to play a primary role the pathogenesis of vascular damage. We investigated whether failure marrow EPC is related their apoptotic phenotype analyzed possible mechanisms inducing apoptosis.The presence was aspirates taken from patients SSc; microvessel density (MVD) immunohistochemical expression growth factor...
Some abnormalities in nailfold videocapillaroscopy (NVC), such as the presence of micro-haemorrhages (MHEs), micro-thromboses (MTs), giant capillaries (GCs) and reduction number (nCs), suggest a disease activity (DA) phase systemic sclerosis (SSc). In previous paper, we showed that (the so-called NEMO score) was NVC feature more closely associated with DA. The present study aimed at validating score measure DA patients SSc. Two cohorts 122 97 SSc who were referred to two different...
Mortality rate in patients infected by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) can be related to the presence of comorbidities like diabetes, cardiovascular and pulmonary diseases. On contrary, few data exist on impact CoronaVirus Disease 2019 (COVID-19) with rheumatic disorders, namely those having involvement treated immunosuppressive agents. The present survey is aimed at knowing COVID-19 a cohort systemic sclerosis (SSc).Telephone interviews were carried out during...
Abstract Background In previous studies, we demonstrated that the NEMO score, i.e. cumulative number of microhaemorrhages (MHEs) and microthromboses (MTs), observed in nailfold videocapillaroscopy was a good indicator steady state level disease activity (DA) patients with systemic sclerosis (SSc) when European Scleroderma Study Group (EScSG) index considered gold standard. Aim study To verify whether score could be (i) valid tool to assess DA, even modified Trials Research (EUSTAR)...
The term pulmonary arterial hypertension (PAH) identifies a heterogeneous group of diseases characterized by progressive increase in resistance (PVR), which causes significant burden terms quality life, right heart failure and premature death. pathogenesis PAH is not completely clear: the remodeling small vessels crucial, causing an circle. Its diagnosis based on cardiac catheterization heart. According to present hemodynamic definition (PH) proposed Guidelines European Society...
Systemic sclerosis (SSc) is one of the most complex connective tissue diseases. Although significant progress in knowledge pathogenic mechanisms and timely diagnosis, therapeutic options remain limited. The attempt to find new treatments for SSc has led researchers investigate potential cellular therapies using autologous allogeneic stem cells. Multipotent mesenchymal stromal cells (MSCs) are considered an attractive candidate cell-based therapies. MSCs comprise a heterogeneous population...
To investigate the gene expression profile in patients with Sjögren's syndrome that is characterized by different clinical phenotypes.RNA from peripheral blood mononuclear cells was purified 8 glandular features (GFs) and widespread pain (WP) 11 extraglandular manifestations (EGMs) then analyzed hybridization on a human chip exploring more than 40,000 genes. Differentially expressed genes (DEGs) two subgroups (ie, those false discovery rate-corrected P values ≤ 0.01) respect to 20 healthy...