Rudi Beschorner
A5056320938- Glioma Diagnosis and Treatment
- Pituitary Gland Disorders and Treatments
- Meningioma and schwannoma management
- Brain Metastases and Treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Adrenal and Paraganglionic Tumors
- S100 Proteins and Annexins
- Hedgehog Signaling Pathway Studies
- Neurofibromatosis and Schwannoma Cases
- Chromatin Remodeling and Cancer
- Neuroblastoma Research and Treatments
- Cerebrospinal fluid and hydrocephalus
- Renal and related cancers
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Histiocytic Disorders and Treatments
- Fetal and Pediatric Neurological Disorders
- Immune Response and Inflammation
- Congenital gastrointestinal and neural anomalies
- Head and Neck Surgical Oncology
- Traumatic Brain Injury and Neurovascular Disturbances
- Cancer Genomics and Diagnostics
- Immune cells in cancer
- Genetic Syndromes and Imprinting
- MRI in cancer diagnosis
University of Tübingen
2015-2025
University Children's Hospital Tübingen
2013-2025
Center for Neuro-Oncology
2025
German Center for Neurodegenerative Diseases
2024
Universitätsklinikum Tübingen
2001-2023
Bernstein Center for Computational Neuroscience Tübingen
2023
German Cancer Research Center
2011-2023
University Hospital and Clinics
2023
University Medical Center
2023
Goethe University Frankfurt
2015-2016
We have recently reported somatic mutations in the ubiquitin-specific protease USP8 gene a small series of adenomas patients with Cushing's disease.To determine prevalence and genotype-phenotype correlation large diagnosed disease.We performed retrospective, multicentric, genetic analysis 134 functioning 11 silent corticotroph using Sanger sequencing. Biochemical clinical features were collected examined within context mutational status USP8, new characterized by functional studies.A total...
Minimally invasive biomarkers are urgently needed to detect molecular pathology in frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). Here, we show that plasma extracellular vesicles (EVs) contain quantifiable amounts of TDP-43 full-length tau, which allow the quantification 3-repeat (3R) 4-repeat (4R) tau isoforms. Plasma EV levels 3R/4R ratios were determined a cohort 704 patients, including 37 genetically 31 neuropathologically proven cases. Diagnostic groups comprised...
The migration of polymorphonuclear granulocytes (PMN) into the brain parenchyma and release their abundant proteases are considered main causes neuronal cell death reperfusion injury following ischemia. Yet, therapies targeting PMN egress have been largely ineffective. To address this discrepancy we investigated temporo-spatial localization PMNs early after transient ischemia in a murine middle cerebral artery occlusion (tMCAO) model human stroke specimens. Using specific markers that...
// Patrick N. Harter 1, 2, 3 , Simon Bernatz 1 Alexander Scholz 4 Pia S. Zeiner 5 Jenny Zinke Makoto Kiyose 6 Stella Blasel Rudi Beschorner 7 Christian Senft 3, 8 Benjamin Bender 9 Michael W. Ronellenfitsch 10 Harriet Wikman 11 Markus Glatzel 12 Matthias Meinhardt 13 Tareq A. Juratli 14 Joachim P. Steinbach Karl H. Plate Jörg Wischhusen 15 Weide 16, 17 Michel Mittelbronn Edinger Institute, Institute of Neurology, University Frankfurt am Main, Germany 2 German Cancer Consortium (DKTK),...
Immune checkpoint blockade therapy is beneficial and even curative for some cancer patients. However, the majority don't respond to immune therapy. Across different tumor types, pre-existing T cell infiltrates predict response checkpoint-based immunotherapy. Based on in vitro pharmacological studies, mouse models analyses of human melanoma patients, we show that cytokine GDF-15 impairs LFA-1/β2-integrin-mediated adhesion cells activated endothelial cells, which a pre-requisite extravasation....
The prognostic significance of atypical histologic features in choroid plexus tumors remains uncertain. Therefore, a series 164 was evaluated for the presence features, including mitotic activity, increased cellularity, nuclear pleomorphism, blurring papillary growth pattern, and necrosis. impact histopathologic clinical on probability recurrence survival investigated. Twenty-four displaying frank signs malignancy were diagnosed as carcinoma according to World Health Organization criteria....
Choroid plexus tumors are intraventricular neoplasms derived from the choroid epithelium. A better knowledge of molecular factors involved in tumor biology may aid identifying patients at risk for recurrence. Methylation profiles were examined 29 papillomas (CPPs, WHO grade I), 32 atypical (aCPPs, II), and 31 carcinomas (CPCs, III) by Illumina Infinium HumanMethylation450 Bead Chip Array. Unsupervised hierarchical clustering identified 3 subgroups: methylation cluster 1 (pediatric CPP aCPP...
Abstract Melanotic tumors of the nervous system show overlapping histological characteristics but differ substantially in their biological behavior. In order to achieve a better delineation such tumors, we performed an in‐depth molecular characterization. Eighteen melanocytomas, 12 melanomas, and 14 melanotic conventional schwannomas (control group) were investigated for methylome patterns (450k array), gene mutations associated with copy number variants ( CNV s). The fingerprints assigned...
Gonadotroph pituitary adenomas (GPAs) often present as invasive macroadenomas not amenable to complete surgical resection. Radiotherapy is the only post-operative option for patients with large or recurrent lesions. No medical treatment available these patients. The somatostatin analogs (SSAs) octreotide and lanreotide that preferentially target receptor type 2 (SSTR2) have little effect on GPAs. It widely accepted expression of specific SSTR subtypes determines response SSAs. Given previous...
Abstract Ependymomas encompass a heterogeneous group of central nervous system (CNS) neoplasms that occur along the entire neuroaxis. In recent years, extensive (epi-)genomic profiling efforts have identified several molecular groups ependymoma are characterized by distinct alterations and/or patterns. Based on unsupervised visualization large cohort genome-wide DNA methylation data, we highly pediatric-type tumors ( n = 40) forming cluster separate from all established CNS tumor types,...
Abstract Papillary tumor of the pineal region ( PTPR ) is a neuroepithelial brain tumor, which might pose diagnostic difficulties and recurs often. Little known about underlying molecular alterations. We therefore investigated chromosomal copy number alterations, DNA methylation patterns mRNA expression profiles in series 24 s. Losses chromosome 10 were identified all 13 s examined. chromosomes 3 22q (54%) as well gains 8p (62%) 12 (46%) also common. profiling using I llumina 450k arrays...
The clinical utility of molecular profiling and targeted therapies for neuro-oncology patients outside trials is not established. We aimed at investigating feasibility therapy in adult with advanced tumors the nervous system within a prospective observational study.molecular tumor board (MTB)@ZPM (NCT03503149) precision medicine study tumors. After inclusion patients, we performed comprehensive profiling, formulated ranked biomarker-guided recommendations based on consensus by MTB, collected...
In brain injury, the primary trauma is followed by a cascade of cellular and molecular mechanisms resulting in secondary injury scar formation. Astrogliosis expression transforming growth factor beta (TGF-β) are key components A cytokine mediating effects TGF-β connective tissue (CTGF), fibrogenic peptide encoded an immediate early gene with suggested roles regeneration aberrant deposition extracellular matrix. order to investigate CTGF traumatic lesions, we evaluated 20 human brains (TBI)...
Object. Secondary damage after central nervous system (CNS) injury is driven in part by oxidative stress and CNS inflammation substantially mediated cyclooxygenases (COXs). To date, the rapidly inducible COX-2 isoform has been primarily linked to inflammatory processes, whereas expression of COX-1 confined physiological functions. The authors report differential localization human traumatic brain (TBI). Methods. Differential cellular protein profiles were analyzed following TBI 31 patients...
<h3>Background</h3> The repulsive guidance molecule (RGM) is involved in formation of the central nervous system during development by moderating repulsion growing axons. However, role RGM adult lesions remains to be clarified. <h3>Objective</h3> To identify and determine expression brains with focal cerebral ischemia or traumatic brain injury neuropathologically unaffected control brains. <h3>Patients</h3> Twenty-one patients ischemia, 25 after injury, 4 <h3>Main Outcome Measure</h3>...
Gonadotroph adenomas comprise 15-40% of all pituitary tumors, are usually non-functioning and often large invasive at presentation. Surgery is the first-choice treatment, but complete resection not always achieved, leading to high recurrence rates. As gonadotroph poorly respond conventional pharmacological therapies, novel treatment strategies needed. Their identification has been hampered by our incomplete understanding molecular pathogenesis these tumors. Recently, we demonstrated that...
Melanoma patients carry a high risk of developing brain metastases, and improvements in survival are still measured weeks or months. Durable disease control within the is impeded by poor drug penetration across blood-brain barrier, as well intrinsic acquired resistance. Augmented mitochondrial respiration key resistance mechanism BRAF-mutant melanomas but, we show this study, dependence on may also be exploited therapeutically. We first used high-throughput pharmacogenomic profiling to...