A5038796778- Neuroendocrine Tumor Research Advances
- Lung Cancer Research Studies
- Pharmacogenetics and Drug Metabolism
- Organ Transplantation Techniques and Outcomes
- Pituitary Gland Disorders and Treatments
- Neuroblastoma Research and Treatments
- Drug Transport and Resistance Mechanisms
- Neuroscience and Neuropharmacology Research
- Liver physiology and pathology
- Receptor Mechanisms and Signaling
- Drug-Induced Hepatotoxicity and Protection
- Neurotransmitter Receptor Influence on Behavior
- 3D Printing in Biomedical Research
- Chemokine receptors and signaling
- Neuropeptides and Animal Physiology
- Metabolism and Genetic Disorders
- Liver Disease and Transplantation
- Monoclonal and Polyclonal Antibodies Research
- Cancer, Hypoxia, and Metabolism
- Immune Response and Inflammation
- Nicotinic Acetylcholine Receptors Study
- Pharmacological Effects and Toxicity Studies
- Adrenal and Paraganglionic Tumors
- Ion channel regulation and function
- Cholinesterase and Neurodegenerative Diseases
Jena University Hospital
2016-2025
Friedrich Schiller University Jena
2013-2023
Schiller International University
2010-2023
Institute of Pharmacology
2011-2021
University of Córdoba
2018
Université Paris Cité
2012-2018
William Harvey Research Institute
2018
Centre de Recherche en Cancérologie de Toulouse
2018
University Medical Center Hamburg-Eppendorf
2018
Université Toulouse III - Paul Sabatier
2018
The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. provides concise overviews, mostly tabular format, key properties nearly 1900 human drug targets with an emphasis on selective pharmacology (where available), plus links open access knowledgebase source and their ligands ( www.guidetopharmacology.org ), which more detailed views target ligand properties. Although constitutes over 500 pages, material presented substantially reduced compared...
To mimic systemic inflammation in humans, different animal models have been developed. Since these are still discussed controversially, we aimed to comparatively evaluate the most widely used with respect effects, influence on organ functions and underlying pathophysiological processes. Systemic was induced C57BL/6N mice lipopolysaccharide (LPS) treatment, peritoneal contamination infection (PCI), or cecal ligation puncture (CLP). Blood glucose circulating cytokine levels were evaluated at...
Experimental studies in a rat model of fecal peritonitis conducted by Michael Bauer and colleagues show that this model, changes liver function occur early the development sepsis, with potential implications for prognosis new therapeutic approaches.
Aims Due to the growing number of somatostatin receptor ( SSTR ) targeting analogues and radiopeptides used for diagnosis therapy neuroendocrine neoplasms NEN ), assessment subtype status has increasingly gained predictive value. In pathology, protein levels are detected routinely by immunohistochemistry IHC ); however, a lack standardized evaluation system persists. Thus, in present investigation, three well‐established semi‐quantitative scoring systems [immunoreactive score IRS human...
Somatotroph adenomas harboring aryl hydrocarbon receptor interacting protein (AIP) mutations respond less well to somatostatin analogs, suggesting that the effects of analogs may be mediated by AIP. The objective investigation was study involvement AIP in mechanism effect analogs. In human study, a 16-wk analog pretreatment compared with no pretreatment. vitro cell line treatment or small interfering RNA (siRNA)/plasmid transfection were studied. conducted at university hospital. Thirty-nine...
// Daniel Kaemmerer 1 , Tina Träger 1, 2 Maike Hoffmeister 3 Bence Sipos Merten Hommann Jörg Sänger 4 Stefan Schulz Amelie Lupp Department of General and Visceral Surgery, Zentralklinik Bad Berka, Germany Pharmacology Toxicology, Jena University Hospital, Friedrich Schiller University, Jena, Institute Pathology, Hospital Tuebingen, Pathology Cytology, Correspondence to: Kaemmerer, e-mail: Daniel.Kaemmerer@zentralklinik.de Keywords: somatostatin receptor, neuroendocrine tumor,...
Gonadotroph pituitary adenomas (GPAs) often present as invasive macroadenomas not amenable to complete surgical resection. Radiotherapy is the only post-operative option for patients with large or recurrent lesions. No medical treatment available these patients. The somatostatin analogs (SSAs) octreotide and lanreotide that preferentially target receptor type 2 (SSTR2) have little effect on GPAs. It widely accepted expression of specific SSTR subtypes determines response SSAs. Given previous...
Therapeutic hypothermia may alter the required dosage of analgesics and sedatives, but no data are available on effects mild plasma fentanyl concentration during continuous, long-term administration. We therefore assessed in a porcine model effect prolonged 33 h continuous Seven female piglets (weight: 11.8 +/- 1.1 kg) were anesthetized by IV (15 microg . kg(-1) h(-1)) midazolam (1.0 mg h(-1)). After preparation stabilization (12 h), animals cooled to core temperature 31.6 degrees 0.2 C for...
In recent years, a large number of groups studied the fate human stem cells in livers immunodeficient animals. However, interpretation results is quite controversial. We transplanted 4 different types extrahepatic precursor (derived from cord blood, monocytes, bone marrow, and pancreas) into nonobese diabetic/severe combined immunodeficiency mice. Human hepatocytes were used as positive controls. Tracking could be achieved by situ hybridization with alu probes. Cells -positive nuclei stained...
Pasireotide (SOM230) is currently under clinical evaluation as a successor compound to octreotide for the treatment of acromegaly, Cushing's disease, and carcinoid tumors. Whereas acts primarily via sst(2A) somatostatin receptor, pasireotide was designed exhibit octreotide-like activity combined with enhanced binding other receptor subtypes. In present study, we used phophosite-specific antibodies examine agonist-induced phosphorylation rat receptor. We show that stimulate complete cluster...
Liver dysfunction affects a variety of metabolic pathways in the critically ill, but mechanisms remain poorly understood. We prospectively assessed markers hepatic injury and function sepsis I/R vivo molecular human liver tissue ex vivo. Markers hepatocellular injury, synthesis, excretion, including plasma disappearance rate indocyanine green (ICG), were measured 48 patients with severe sepsis. Incidence was 42% as by hyperbilirubinemia 74% impaired dye excretion. Conventional for failed to...
A codrug of the anti-Alzheimer drug tacrine and natural product silibinin was synthesized. The codrug's biological pharmacological properties were compared to an equimolar mixture components. compound showed potent acetyl- butyrylcholinesterase inhibition. In a cellular hepatotoxicity model, analyzing influence on viability mitochondria hepatic stellate cells (HSC), toxicity markedly reduced in comparison that tacrine. Using neuronal cell line (HT-22), neuroprotective effect against...
The frequent overexpression of somatostatin receptors (sst) in neuroendocrine tumors provides the molecular basis for diagnostic and therapeutic application stable analogs. Whereas octreotide acts mainly via sst(2) receptor, novel pan-somatostatin analog pasireotide exhibits particular high affinity sst(5) receptor. To determine whether a patient is candidate or therapy, it important to evaluate receptor status. However, so far highly specific rabbit monoclonal antibodies have been developed...