A5101705331- 3D Printing in Biomedical Research
- Innovative Microfluidic and Catalytic Techniques Innovation
- Microfluidic and Capillary Electrophoresis Applications
- Biosensors and Analytical Detection
- Renal Transplantation Outcomes and Treatments
- Bacterial Identification and Susceptibility Testing
- Microfluidic and Bio-sensing Technologies
- Analytical Chemistry and Sensors
- Metabolism and Genetic Disorders
- Liver physiology and pathology
- Barrier Structure and Function Studies
- Pancreatic function and diabetes
- Pneumocystis jirovecii pneumonia detection and treatment
- Neonatal Respiratory Health Research
- Soft tissue tumors and treatment
- Organ Transplantation Techniques and Outcomes
- Cancer and Skin Lesions
- Cell Image Analysis Techniques
- Antibiotics Pharmacokinetics and Efficacy
- Antibiotic Resistance in Bacteria
- Acute Lymphoblastic Leukemia research
- Soft tissue tumor case studies
- Renal and related cancers
- Antifungal resistance and susceptibility
Microfluidic ChipShop (Germany)
2014-2024
University of Basel
2010
Carl Zeiss (Germany)
2008
Hematopoietic lymphoid tissue inducer (LTi) cells initiate lymph node (LN) and Peyer's patch (PP) development during fetal life by inducing the differentiation of mesenchymal organizer cells. The growth factor signals underlying LTi cell LN PP organogenesis remain poorly understood. express Il7r receptor tyrosine kinase Kit, whereas their cognate ligands. To determine relative significance Il7 Kit signaling in homeostasis development, we have analyzed mice deficient for (Kit(W/Wv)),...
The development of therapeutic substances to treat diseases the central nervous system is hampered by tightness and selectivity blood-brain barrier. Moreover, testing potential drugs time-consuming cost-intensive. Here, we established a new microfluidically supported, biochip-based model brain endothelial barrier in combination with cortical spheroids suitable detect effects neuroinflammation upon disruption layer response inflammatory signals. Unilateral perfusion cell cytokine mix...
For many problems in system biology or pharmacology, in-vivo-like models of cell-cell interactions organ functions are highly sought after. Conventional stationary cell culture 2D plates quickly reaches its limitations with respect to an in-vivo like expression and function individual types. Microfabrication technologies microfluidics offer attractive solution these problems. The ability generate flow as well geometrical conditions for manipulation close the situation allows improved design...
Cell-based assays and organ-like substrates gather increasing attention due to their potentials in diagnostic drug development. The use of these cell-based systems will allow better understand in-vivo processes test for the direct influence different substances on cell viability or metabolic activity e.g. development addition identify generated metabolites types. In this paper we present a respective technical platform, which enables such assays. platform is based microfluidic cell-assay...
Bacterial infection clusters cause high mortality rates and healthcare costs due to excessive therapy hygiene measures. The aim of this study was develop an automated real-time PCR-based point-of-care (POC) system with a customized microfluidic chip that facilitates fast detection bacterial cluster isolates by targeting cluster-specific single-nucleotide polymorphisms (SNPs). For
In many diagnostic fields a massive trend towards bringing the procedure closer to patient in space and time can be observed. This so-called Point-of-Care diagnostics (POC) greatly benefits from recent advances microfabrication technologies, namely field of polymer based microsystems [1]. is more important as there pressure reducing cost all aspects health-care market has traditionally been seen low-cost high-volume which makes it difficult for new technologies break into they tend have...
A novel therapeutic drug monitoring point of care testing (POCT) optical device for the detection immunosuppressants in transplanted patients was designed and tested, with body interface constituted by an intravascular microdialysis catheter (MicroEye®) which provides dialysate as clinical sample. An biochip 10 microchannels, based on total internal reflection fluorescence (TIRF), enables frequent measurement immunosuppressants. Heterogeneous competitive immunoassays mycophenolic acid,...