A5072063834- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- Advanced Radiotherapy Techniques
- Prostate Cancer Diagnosis and Treatment
- Autism Spectrum Disorder Research
- Prostate Cancer Treatment and Research
- Radiomics and Machine Learning in Medical Imaging
- Brain Metastases and Treatment
- Neurofibromatosis and Schwannoma Cases
- Functional Brain Connectivity Studies
- Colorectal Cancer Treatments and Studies
- Management of metastatic bone disease
- Radiation Therapy and Dosimetry
- Obsessive-Compulsive Spectrum Disorders
- Colorectal and Anal Carcinomas
- Neuroendocrine Tumor Research Advances
- Heme Oxygenase-1 and Carbon Monoxide
- Cutaneous lymphoproliferative disorders research
- Medical Practices and Rehabilitation
- Lung Cancer Research Studies
- Cardiac tumors and thrombi
- Vascular Malformations and Hemangiomas
- Bone Tumor Diagnosis and Treatments
- Fungal Infections and Studies
- Cell Adhesion Molecules Research
University Children's Hospital Tübingen
2023-2025
University of Tübingen
2016-2025
Bernstein Center for Computational Neuroscience Tübingen
2021-2024
Universitätsklinikum Tübingen
2024
Klinik und Poliklinik für Psychiatrie und Psychotherapie
2015
Abstract Background Myxoid liposarcoma (MLPS) is a rare subtype of soft tissue sarcoma. This entity has specific clinical behavior, characterized with distinct pattern hematogenous spread, as well unique radiosensitivity and chemosensitivity. Oncologic results, metastatic patterns treatment response after multimodal therapy were evaluated in unicentric patient cohort. Methods Patients myxoid retrospectively analyzed single institution analysis ( n = 31). outcomes 28 patients localized MLPS...
Abstract Since the introduction of Simpson grading for extent resection in meningiomas 1957, its usefulness modern neurosurgery has been challenged. Especially, updated WHO classification regarding brain invasion and efficacy radiation therapy not taken into account when evaluating prognostic role this era. We analyzed clinical histopathological data 1571 that were surgically resected authors’ institution between July 2003 March 2017. Operative reports reviewed according to grading....
The clinical utility of molecular profiling and targeted therapies for neuro-oncology patients outside trials is not established. We aimed at investigating feasibility therapy in adult with advanced tumors the nervous system within a prospective observational study.molecular tumor board (MTB)@ZPM (NCT03503149) precision medicine study tumors. After inclusion patients, we performed comprehensive profiling, formulated ranked biomarker-guided recommendations based on consensus by MTB, collected...
Zusammenfassung In der Primärtherapie des Prostatakarzinoms stehen verschiedene Stadienadaptierte radioonkologische Therapiekonzepte zur Verfügung, teilweise kombiniert mit einer antiandrogenen Therapie (ADT). Fortschritte in bildgesteuerten (IGRT) und intensitätsmodulierten Strahlentherapie (IMRT) Brachytherapie ermöglichen die Applikation hoher Strahlendosen damit eine hohe Tumorkontrolle bei gleichzeitig günstigem Nebenwirkungsprofil.
Abstract Purpose Extensive-stage small cell lung cancer (ES-SCLC) carries a dismal prognosis. The benefit of consolidative thoracic radiotherapy (TR) after first-line chemoimmunotherapy with PD-L1 inhibitors in this setting remains unclear. As TR can improve overall survival (OS) conventional chemotherapy, we retrospectively analyzed OS an inhouse cohort treated either or alone. Methods A total 41 patients (atezolizumab durvalumab) for ES-SCLC at our hospital since 2019 were analyzed. was...
Abstract Background Little is known about the growth dynamics of untreated glioblastoma and its possible influence on postoperative survival. Our aim was to analyze a association preoperative with Methods We performed retrospective analysis all adult patients surgically treated for newly diagnosed at our center between 2010 2020. By volumetric data availability ≥3 sequential MRI, pattern aimed be identified. Main inclusion criterion further two MRI scans slice thickness 1 mm, least 7 days...
The use of hypofractionated radiotherapy in prostate cancer has been increasingly evaluated, whereas accumulated evidence demonstrates comparable oncologic outcomes and toxicity rates compared to normofractionated radiotherapy. In this prospective study, we evaluate all patients with intermediate-risk treated ultrahypofractionated (UHF) MRI-guided on a 1.5 T MR-Linac within our department report workflow feasibility, as well physician-recorded patient-reported longitudinal toxicity. A total...
The influence of radiotherapy on patient immune cell subsets has been established by several groups. Following a previously published analysis changes during and after curative for prostate cancer, this focused describing correlations with radiation treatment parameters.For 13 patients treated in prospective trial to the region (primary analysis) five pelvic nodal regions (exploratory analysis), already monitoring data were correlated clinical as well planning parameters such target volume...
The expression of somatostatin receptors in meningioma is well established. First, suggestions a prognostic impact SSTRs have been made. However, the knowledge based on few investigations small cohorts. We recently analyzed all five known large cohort over 700 meningiomas and demonstrated significant correlations with WHO tumor grade other clinical characteristics. therefore expanded our dataset additionally collected information about radiographic recurrence progression as clinically...
Abstract Introduction Meningiomas are the most common benign intracranial neoplasms. CNS invasion in meningiomas has been integrated into 2016 WHO classification of tumors as a stand-alone criterion for atypia. Since then, its prognostic impact debated based on contradictory results from retrospective analyses. The aim study was to elucidate whether histopathological evidence is associated with increased proliferative potential. Methods We have conducted quantified measurement proliferation...
Background and purposeThe PRIDE trial (NOA-28; ARO-2022-12; NCT05871021) is scheduled to start recruitment in October 2023. Its primary objective enhance median overall survival (OS), compared historical OS rates, patients with methylguanine methlyltransferase (MGMT) promotor unmethylated glioblastoma by incorporating isotoxic dose escalation 75 Gy 30 fractions. To achieve isotoxicity counteract the elevated risk of radiation necrosis (RN) associated dose-escalated regimens, addition...
A 56-year-old alcoholic developed primary meningoencephalitis and died 3 weeks later. Autopsy revealed multiple areas of necrosis acute granulomatous inflammation in the brain pancreas. Trophozoites cysts were discovered trophozoites alone Morphologic studies some parasitic features described as characteristic for Naegleria, but clinical, histological immunohistological favored an Acanthamoeba infection. This study calls caution use pure morphological criteria differential diagnosis...
Atypical meningiomas exhibit a high tendency for tumor recurrence even after multimodal therapy. Information regarding patterns additive radiotherapy is scarce but could improve planning and therapy decision. We conducted an analysis of with regard to target volumes dose coverage assessing volume definition postulated areas re-growth origin. Prognostic factors contributing relapse were evaluated.The clinical outcome patients who had completed additive, somatostatin receptor...
Abstract Laughter plays an important role in group formation, signaling social belongingness by indicating a positive or negative intention towards the receiver. In adults without autism, of laughter can be correctly differentiated further contextual information. autism spectrum disorder (ASD), however, differences perception and interpretation cues represent key characteristic disorder. Studies suggest that these are associated with hypoactivation altered connectivity among nodes network....
Abstract Acute febrile neutrophilic dermatosis (Sweet‘s syndrome) is a dermatological entity, which may be associated with malignancies, drugs, and infections characterized by high fever, elevated neutrophils, tender erythematous skin lesions. Involvement of the nervous system – Neuro-Sweet syndrome (NSS) - rare, manifesting most commonly an encephalitic in addition to fever dermal Here, we report unusual case NSS Caucasian male patient setting B-cell-lymphocytosis, encephalitis preceding...
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