A5065597367- Glioma Diagnosis and Treatment
- Acute Ischemic Stroke Management
- Atrial Fibrillation Management and Outcomes
- Venous Thromboembolism Diagnosis and Management
- Neuroblastoma Research and Treatments
- Brain Metastases and Treatment
- Cancer survivorship and care
- Radiomics and Machine Learning in Medical Imaging
- Neurofibromatosis and Schwannoma Cases
- Medical Imaging Techniques and Applications
- Neurological Complications and Syndromes
- Economic and Financial Impacts of Cancer
- Peripheral Neuropathies and Disorders
- Neurological and metabolic disorders
- Social Media in Health Education
- Meningioma and schwannoma management
- Palliative Care and End-of-Life Issues
- Medical Practices and Rehabilitation
- Head and Neck Surgical Oncology
- Advanced Breast Cancer Therapies
- Traumatic Brain Injury and Neurovascular Disturbances
- Biomedical and Chemical Research
- Pharmacological Effects and Toxicity Studies
- Myasthenia Gravis and Thymoma
- Breast Cancer Treatment Studies
Hertie Institute for Clinical Brain Research
2019-2024
University of Tübingen
2020-2024
University Children's Hospital Tübingen
2023-2024
Bernstein Center for Computational Neuroscience Tübingen
2023-2024
Universitätsklinikum Tübingen
2024
BACKGROUND: Rivaroxaban and dabigatran were not superior to aspirin in trials of patients with embolic stroke undetermined source (ESUS). It is unknown whether apixaban ESUS known risk factors for cardioembolism. METHODS: We conducted a multicenter, randomized, open-label, blinded-outcome trial (5 mg twice daily) compared (100 once initiated within 28 days after at least one predictive factor atrial fibrillation or patent foramen ovale. Cardiac monitoring was mandatory, treatment switched...
The clinical utility of molecular profiling and targeted therapies for neuro-oncology patients outside trials is not established. We aimed at investigating feasibility therapy in adult with advanced tumors the nervous system within a prospective observational study.molecular tumor board (MTB)@ZPM (NCT03503149) precision medicine study tumors. After inclusion patients, we performed comprehensive profiling, formulated ranked biomarker-guided recommendations based on consensus by MTB, collected...
Abstract Background Direct oral anticoagulants (DOAC) including edoxaban are increasingly used for stroke prevention in atrial fibrillation. Despite treatment, annual rate these patients remains 1–2%. Rapid assessment of coagulation would be useful to guide thrombolysis or reversal therapy this growing population DOAC/edoxaban-treated patients. Employing the Hemochron™ Signature Elite point-of-care test system (HC-POCT), clinically relevant plasma concentrations dabigatran and rivaroxaban...
Abstract In current international classification systems (ICD-10, DSM5), the diagnostic criteria for psychotic disorders (e.g. schizophrenia and schizoaffective disorder) are based on symptomatic descriptions since no unambiguous biomarkers known to date. However, when underlying causes of symptoms, like inflammation, ischemia, or tumor affecting neural tissue can be identified, a different is used ("psychotic disorder with delusions due physiological condition" (ICD-10: F06.2) psychosis...
Abstract Background Little is known about the growth dynamics of untreated glioblastoma and its possible influence on postoperative survival. Our aim was to analyze a association preoperative with Methods We performed retrospective analysis all adult patients surgically treated for newly diagnosed at our center between 2010 2020. By volumetric data availability ≥3 sequential MRI, pattern aimed be identified. Main inclusion criterion further two MRI scans slice thickness 1 mm, least 7 days...
A fully diagnostic MRI glioma protocol is key to monitoring therapy assessment but time-consuming and especially challenging in critically ill uncooperative patients. Artificial intelligence demonstrated promise reducing scan time improving image quality simultaneously. The purpose of this study was investigate the performance, impact on acquisition acceleration, a deep learning optimized brain. Thirty-three patients with histologically confirmed glioblastoma underwent standardized brain...
Abstract Edoxaban, alongside other direct oral anticoagulants (DOAC), is increasingly used for prevention of thromboembolism, including stroke. Despite DOAC therapy, however, annual stroke rate in patients with atrial fibrillation remains 1–2%. Rapid exclusion relevant anticoagulation necessary to guide thrombolysis or reversal therapy but, so far, no data exists on the effect edoxaban available point-of-care test systems (POCT). To complete our previous investigation global coagulation-POCT...
Background Within the past 10 years, immune mechanisms associated with acute ischemic stroke (AIS) have been brought into focus, but data on B cell activation and intrathecal Ig production is still scarce. In this study, we determined prevalence of an elevated IgG index, positive oligoclonal bands (OCBs) chemokine C-X-C motif ligand 13 (CXCL13) levels in cerebrospinal fluid (CSF) as markers synthesis patients AIS. Methods a retrospective study analyzed from 212 AIS December 2013 to May 2018...
Abstract BACKGROUND Once first-line therapy options fail, there are no effective for most neuro-oncological conditions, including glioblastoma, gliomas, and brain metastases, thereby representing a high unmet clinical need. Novel targeted often explored in small phase-I studies or given as off-label therapies. Assessment of treatment efficacy this setting is challenging should incorporate outcome measures such progression-free survival (PFS) objective response rate (ORR) well parameters. To...
Biomarker-based therapies are increasingly used in cancer patients outside clinical trials. Systematic assessment of patient-reported outcomes (PRO) is warranted to take patients' perspectives during biomarker-based into consideration. We assessed the feasibility an electronic PRO via a smartphone application. An interdisciplinary expert panel developed application based on symptom burden and health-related quality life (HRQoL) metrics reported retrospective analysis 292 neuro-oncological...
Zusammenfassung Das Glioblastom gehört zu den häufigsten primären Tumoren des zentralen Nervensystems und ist mit einer ungünstigen Prognose verbunden. Die Kriterien für eine integrierte Diagnose basieren auf histologischen molekularen Merkmalen, die in der aktuellen Klassifikation Weltgesundheitsorganisation verankert sind. postoperative Erstlinientherapie besteht Kombination von Radiotherapie, Temozolomidchemotherapie (je nach molekularem Profil, Alter klinisch-neurologischem Zustand...
A 61-year-old patient was diagnosed with a left-sided falx meningioma. Histopathological analysis following extirpation showed meningothelial meningioma ZNS WHO grade 1 sparse mitoses. Over the course of 12 years, received irradiation (54.0 Gy), peptide radio-receptor therapy (177Lu-DOMITATE) and targeted (mTOR inhibitor). Follow-up imaging revealed an increased size residual tumor. Due to liver function parameters, performed, showing widespread space-occupying lesions atypical appearance....
Abstract BACKGROUND Despite multimodal treatment (resection, radiation therapy, alkylating chemotherapy and/or tumor-treating fields), the of progressive CNS WHO Grade 3 astrocytoma and glioblastoma remains challenging. Re-irradiation (Re-RT) might be considered in course disease. Optimal fractionation/dose prescription schedules are still under investigation, underlining a gap clinical data this regard. Here, we retrospectively analyzed post-progression survival (PPS) progression-free (PFS)...
Background and Objectives: Immune checkpoint inhibitors (ICIs) have enriched tumor therapy, improving overall survival. Immunotherapy adverse events (irAEs) occur in up to 50% of patients also affect the peripheral nervous system. The exact pathomechanism is unclear; however, an autoimmune process implicated. Thus, clinical evaluation irAEs system still demanding. We retrospectively analyzed nerve ultrasound (NU) data polyneuropathies (PNPs) secondary inhibitors. Materials Methods: NU with...
Abstract BACKGROUND Comprehensive genomic profiling and biomarker-based therapies are increasingly used in clinical trials innovative health care systems including the center for personalized medicine network. Systematic assessments of patient-reported outcomes (PRO) warranted to gain insight into perspective patients during therapies. In present study, we focused on feasibility compliance an electronic PRO assessment treated at our center. MATERIAL AND METHODS Based a retrospective...
Abstract BACKGROUND The diagnosis of a brain tumor represents high burden for patients’ caregivers. Psychosocial screening tools caregivers adapted to neuro-oncological entities are urgently required but do not exist. To bridge this gap, we aim develop problem list in terms holistic need assessment tailored their unmet needs an application combination the NCCN distress thermometer scale. MATERIAL AND METHODS First, items relevance were identified on basis retrospective analyses. Second,...
Myasthenia gravis (MG) is a heterogeneous autoimmune disease, which characterized by postsynaptic neuromuscular transmission defect, with antibodies directly targeting the acetylcholine receptor (AChR) or other structural proteins of junction. The majority MG cases are associated thymic pathologies, including thymoma, thyroiditis, diseases malignant hematologic neoplasia. present study reported rare case AChR‑positive and late‑onset ocular MG, rapidly progressed to generalized myasthenic...
Abstract OBJECTIVE The diagnosis of a brain tumor represents high burden for the patients’ caregivers (CG). Psychosocial screening tools adapted to profile CG are urgently required but do not exist. aim was develop problem list neuro-oncological CGs’ unmet needs an application in combination Distress Thermometer scale. METHODS were prospectively assessed regarding changes everyday life, relationship, social emotional, physical problems, and support needs, either via questionnaire (Center A)...
Abstract Comprehensive genomic profiling and biomarker-based therapeutic strategies are currently used in clinical trials innovative health care systems including the center for personalized medicine network. Systematic assessments of patient-reported outcomes warranted to gain insight into perspective patients their relatives during therapies. In present study, we focused on health-related quality life (HRQoL), psychosocial situation, physical symptoms treated at Center Personalized...