A5041879855- Intracranial Aneurysms: Treatment and Complications
- Cerebrovascular and Carotid Artery Diseases
- Advanced MRI Techniques and Applications
- Moyamoya disease diagnosis and treatment
- Advanced Neuroimaging Techniques and Applications
- Acute Ischemic Stroke Management
- MRI in cancer diagnosis
- Glioma Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Functional Brain Connectivity Studies
- Vascular Malformations Diagnosis and Treatment
- Medical Imaging Techniques and Applications
- Neurological Complications and Syndromes
- Intracerebral and Subarachnoid Hemorrhage Research
- Advanced X-ray and CT Imaging
- Meningioma and schwannoma management
- Genetic Neurodegenerative Diseases
- Radiation Dose and Imaging
- Neonatal and fetal brain pathology
- Venous Thromboembolism Diagnosis and Management
- Neurological disorders and treatments
- Mitochondrial Function and Pathology
- Cerebral Venous Sinus Thrombosis
- Radiomics and Machine Learning in Medical Imaging
- Neurosurgical Procedures and Complications
University of Tübingen
2016-2025
Universitätsklinikum Tübingen
2018-2024
University Children's Hospital Tübingen
2015-2023
Hertie Institute for Clinical Brain Research
2003-2020
Endress+Hauser (Switzerland)
2020
Society of Interventional Radiology
2011-2019
Paracelsus Medical University
2010-2012
German Cancer Research Center
2010-2011
Heidelberg University
2010-2011
DKFZ-ZMBH Alliance
2010-2011
Spinocerebellar ataxias are dominantly inherited disorders that associated with progressive brain degeneration, mainly affecting the cerebellum and brainstem. As part of multicentre European integrated project on spinocerebellar study, 37 patients ataxia-1, 19 ataxia-3 seven ataxia-6 were clinically examined underwent magnetic resonance imaging at baseline after a 2-year follow-up. All compared age-matched gender-matched healthy control subjects. Magnetic analysis included three-dimensional...
The observation that human meningioma cells strongly express somatostatin receptor (SSTR 2) was the rationale to analyze retrospectively in how far DOTATOC PET/CT is helpful improve target volume delineation for intensity modulated radiotherapy (IMRT).In 26 consecutive patients with preferentially skull base meningioma, diagnostic magnetic resonance imaging (MRI) and planning-computed tomography (CT) complemented data from [(68)Ga]-DOTA-D Phe(1)-Tyr(3)-Octreotide (DOTATOC)-PET/CT. Image...
<h3>BACKGROUND AND PURPOSE:</h3> IR has recently demonstrated its capacity to reduce noise and permit dose reduction in abdominal thoracic CT applications. The purpose of our study was assess the potential benefit head by comparing objective subjective image quality with standard FBP at various levels. <h3>MATERIALS METHODS:</h3> Ninety consecutive patients were randomly assigned undergo nonenhanced contrast-enhanced a (320 mAs; CTDI, 60.1) or 15% (275 51.8) 30% (225 42.3) reduction. All...
Endovascular therapy is the standard of care in treatment acute ischemic stroke due to large-vessel occlusion. Often, more than one retrieval attempt needed achieve reperfusion. We aimed quantify influence endovascular on clinical outcome depending number retrievals for successful reperfusion a large multi-center cohort. For this observational cohort study, 2611 patients from prospective German Stroke Registry included between June 2015 and April 2018 were analyzed. Patients who received...
Background/Objectives: The non-invasive identification of glioma subtypes is useful for initial diagnosis, treatment planning, and follow-up. aim this study was to evaluate the performance diffusion kurtosis imaging (DKI) dynamic contrast-enhanced (DCE)-MRI in differentiating adult-type diffuse gliomas. Methods: In a prospective multicenter study, standardized MRI analyzed 59 patients with glioma. DKI DCE-MRI parameter values were quantitatively evaluated ROIs contrast-enhancing/solid tumor...
Abstract It was shown recently that functional activation across brain motor areas during locomotion and foot movements are similar but differ substantially from related to upper extremity movement (Miyai [ 2001 ]: Neuroimage 14:1186–1192). The pattern may be a function of the behavioral context rather than its mechanical properties. We compare system patterns associated with isolated single‐joint corresponding joints in arm leg carried out equal frequency range. Eleven healthy volunteers...
Background Patients aged ≥90 were excluded or under‐represented in past thrombectomy trials; thus, uncertainty remains whether treatment benefits can be expected regardless of age. This study investigates outcome and safety nonagenarians to improve decision making a real‐world setting. Methods Results All currently available data patients enrolled the GSR‐ET (German Stroke Registry–Endovascular Treatment) combined with smaller cohort from 3 tertiary stroke centers. Baseline characteristics,...
Endovascular therapy is the standard of care in treatment acute ischemic stroke due to large-vessel occlusion. A direct association between number device passes and occurrence symptomatic intracranial hemorrhage (SICH) has been suggested. This study represents an in-depth investigation hypothesis that >3 retrieval attempts associated with increased rate SICH a large multicenter patient cohort. Two thousand six hundred eleven patients from prospective German Stroke Registry were analyzed....
This study evaluates the benefit of endovascular treatment (EVT) for patients with extensive baseline stroke compared best medical treatment.This retrospective, multicenter compares EVT and computed tomography (CT)–based selection infarcts (Alberta Stroke Program Early CT Score ≤5) attributed to anterior circulation stroke. Patients were selected from German Registry 3 tertiary centers. Primary functional end points rates good (modified Rankin Scale score ≤3) very poor outcome ≥5) at 90...
Patients with symptomatic internal carotid artery (ICA) stenosis are at high risk of recurrent ischemic stroke and require early interventional treatment antiplatelet therapy. Increased bleeding rates might counterbalance the periprocedural efficacy intensified platelet inhibition. We aim to investigate, whether Revacept, a competitive antagonist glycoprotein VI, adjunct standard therapy reduces occurrence lesions in patients ICA stenosis.International, multicenter (16 sites), 3-arm,...
Current treatment outcome of patients with glioblastoma (GBM) remains poor. Following standard therapy, recurrence is universal limited survival. Tumors from 173 GBM are analysed for somatic mutations to generate a personalized peptide vaccine targeting tumor-specific neoantigens. All were treated within the scope an individual healing attempt. Among all vaccinated patients, including 70 prior progression (primary) and 103 after (recurrent), median overall survival first diagnosis 31.9...
Abstract Introduction Low back pain is a global health issue causing disability and missed work days. Commonly used MRI scans including T1-weighted T2-weighted images provide detailed information of the spine surrounding tissues. Artificial intelligence showed promise in improving image quality simultaneously reducing scan time. This study evaluates performance deep learning (DL)-based T2 turbo spin-echo (TSE, DLR ) T1 TSE (T1 lumbar imaging regarding acquisition time, quality, artifact...
To evaluate the feasibility of a multimodal approach involving dynamic contrast-enhanced (DCE) perfusion imaging and diffusion kurtosis (DKI) in preoperative brain tumors multicenter setting, to effect on diagnostic confidence accuracy for tumor grade type prediction.
Objective We investigate how known differences in myelin architecture between regions along the cortico-spinal tract and frontal white matter (WM) 19 healthy adolescents are reflected several quantitative MRI parameters that have been proposed to non-invasively probe WM microstructure. In a clinically feasible scan time, both conventional imaging sequences as well microstructural were assessed order quantitatively characterise differ thickness of their sheaths, presence crossing or parallel...
Progressive multifocal leukoencephalopathy is a severe demyelinating disease caused by the polyoma JC virus in patients with reduced immunocompetence. A few cases of progressive have been reported treated fumaric acid esters.A 53-year-old Caucasian woman to our clinic first focal epileptic seizure and mild cognitive impairment. Since 1.5 years, she was fumaderm for her psoriasis. During that time, lymphocyte counts ranged between 450 700/μl. Cerebral magnet resonance imaging showed...
Patients with Moyamoya Disease (MMD) need hemodynamic evaluation of vascular territories at risk stroke. Today's investigative standards include H215O PET/CT pharmacological challenges acetazolamide (ACZ). Recent developments suggest that CO2-triggered blood‑oxygen-level-dependent (BOLD) functional MRI might provide comparable results to current standard methods for territorial hemodynamics, while being a more widely available and easily implementable method. This study examines newly...
Only limited data are available about a potential benefit associated with endovascular treatment (EVT) for patients ischemic stroke presenting in the extended time window who also show signs of extensive infarction.To assess association recanalization after EVT functional outcomes infarction.This retrospective, multicenter cohort study included enrolled German Stroke Registry-Endovascular Treatment an Alberta Program Early CT Score (ASPECTS) 5 or less presented between 6 and 24 hours onset...
Very preterm (PT) birth (32 weeks of gestation) carries a high risk for an adverse neurodevelopmental outcome.In recent years, the importance neurocognitive deficits in language domain has been increasingly recognized, which can be well-characterized using neuropsychological testing and noninvasive imaging approaches.We compared former early PT born children adolescents (PT, n 5 29, 20M) typically developing (TD, 19, 7M), conventional fMRI group analyses as well functional connectivity...
Abstract Early postnatal infection with human cytomegalovirus (hCMV) may contribute to an adverse cognitive outcome in early preterm‐born children (PT). We here set out explore whether long‐term neurobiological consequences of such are detectable using fMRI and adolescents who were born very preterm either did (PT hCMV+ ) or not hCMV− suffer from hCMV‐infection, when compared typically developing healthy control (HC) subjects. Overall, data 71 could be included, 34 PT (of which 15 hCMV + 19...
Background/Objectives: The purpose of this study was to evaluate the performance diffusion kurtosis imaging (DKI), neurite orientation dispersion and density (NODDI), microstructure (DMI) in differentiating molecular subtypes adult-type gliomas. Methods: Standardized MRI performed evaluated 59 patients with glioma. DKI, NODDI, DMI parameter values were quantitatively ROIs contrast-enhancing/solid tumor tissue five concentric shells peritumoral tissue. parameters (i) glioblastomas, Isocitrate...