A5088721513- Heart Rate Variability and Autonomic Control
- Antiplatelet Therapy and Cardiovascular Diseases
- Heart rate and cardiovascular health
- Heart Failure Treatment and Management
- Acute Myocardial Infarction Research
- Non-Invasive Vital Sign Monitoring
- Vasculitis and related conditions
- ECG Monitoring and Analysis
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Cardiac Valve Diseases and Treatments
- Cardiovascular Function and Risk Factors
- Protease and Inhibitor Mechanisms
- Emergency and Acute Care Studies
- Ocular Diseases and Behçet’s Syndrome
- Systemic Lupus Erythematosus Research
- Probiotics and Fermented Foods
- Acute Ischemic Stroke Management
- Lipoproteins and Cardiovascular Health
- Cardiac Arrhythmias and Treatments
- Complement system in diseases
- Blood Coagulation and Thrombosis Mechanisms
- Cardiac Arrest and Resuscitation
- Cardiovascular Syncope and Autonomic Disorders
- Atherosclerosis and Cardiovascular Diseases
- Adipokines, Inflammation, and Metabolic Diseases
University of Tübingen
2015-2023
University Children's Hospital Tübingen
2018-2022
Deutsche Forschungsgemeinschaft
2017
BACKGROUND: Rivaroxaban and dabigatran were not superior to aspirin in trials of patients with embolic stroke undetermined source (ESUS). It is unknown whether apixaban ESUS known risk factors for cardioembolism. METHODS: We conducted a multicenter, randomized, open-label, blinded-outcome trial (5 mg twice daily) compared (100 once initiated within 28 days after at least one predictive factor atrial fibrillation or patent foramen ovale. Cardiac monitoring was mandatory, treatment switched...
Objectives: To evaluate heart rate deceleration capacity, an electrocardiogram-based marker of autonomic nervous system activity, as risk predictor in a medical emergency department and to test its incremental predictive value the modified early warning score. Design: Prospective cohort study. Setting: Medical large university hospital. Patients: Five thousand seven hundred thirty consecutive patients either sex sinus rhythm, who were admitted University Tübingen, Germany, between November...
Background Risk prediction in patients with severe aortic stenosis ( AS ) undergoing transcatheter valve implantation TAVI is challenging. Development of novel markers for patient risk assessment great clinical value. Deceleration capacity DC heart rate a strong predictor post‐infarction patients. Hypothesis provides prognostic information . Methods We enrolled 374 consecutive All received 24‐hour Holter recording or continuous heart‐rate monitoring to assess before intervention. Primary...
Lactobacillus species are Gram-positive, facultative anaerobic, rod-shaped bacteria. They belong to the lactic acid bacteria group and also known as a usual part of normal flora gastrointestinal tract well urinary genital tracts. an infrequent human pathogen but can induce several infections such bacteremia infectious endocarditis. We report case 81-year-old woman with mitral valve endocarditis splenic abscesses.
Platelets express the transmembrane chemokine SR-PSOX/CXCL16, proteolytic cleavage of which generates sCXCL16 soluble-(s) chemokine. The engages CXCR6 on platelets to synergistically propagate degranulation, aggregation and thrombotic response. Currently, we have investigated pro-thrombotic prognostic association platelet CXCL16–CXCR6 axis in CAD-(n = 240; CCS n 62; ACS 178) patients. Platelet surface-associated-CXCL16 surface expression ascertained by flow cytometry correlated significantly...
Background Patients with acute coronary syndrome (ACS) are at risk especially in the period shortly after event. Alterations respiratory control have been associated adverse prognosis. The aim of our study was to assess if nocturnal rate (NRR) is a predictor mortality patients ACS presenting emergency department. Methods Clinically stable consecutive aged ≥ 18 years were prospectively enrolled. Global Registry Acute Coronary Events (GRACE) score and left ventricular ejection fraction (LVEF)...
Hughes-Stovin syndrome (HSS) is a rare autoimmune vasculitis and characterized by the simultaneous presence of deep venous thrombosis pulmonary artery aneurysms. The exact etiology pathogenesis this life-threatening currently unknown. disease thought to be variant Behcet’s with major vascular involvement. Here we report case 19-year-old man from West Africa severe cardiovascular manifestation HSS. patient was referred our hospital dyspnoea, recurrent fever swelling left leg. Echocardiography...
Syncope is a common cause for admission to the emergency department (ED). Due limited clinical resources there great interest in developing risk stratification tools that allow identifying patients with syncope who are at low and can be safely discharged. Deceleration capacity (DC) strong predictor postinfarction heart failure patients. The aim of this study was evaluate whether DC provides prognostic information presenting ED syncope. We prospectively enrolled 395 due Patient's...
Background: Complement component 5a (C5a) is a highly potent anaphylatoxin with variety of pro-inflammatory effects. C5a contributes to progression atherosclerosis and inhibition the receptor (C5aR) might offer therapeutic strategy in this regard. Single nucleotide polymorphisms (SNPs) C5 gene may modify protein expression levels therefore function C5aR. This study aimed examine associations between clinically relevant SNPs prognosis patients symptomatic coronary artery disease (CAD)....
Abstract Introduction Thromboischemic and bleeding events are rare but potentially life-threatening complications after percutaneous coronary intervention (PCI). Consequently, duration of dual antiplatelet therapy (DAPT) stent implantation might be altered due to or thromboischemic risk. Various risk assessment models have been established predict adverse in patients with symptomatic artery disease (CAD). The aim the present study was compare available scoring systems based on their...
Abstract Background Matrix Metalloproteinase-2 (MMP-2) is involved in regulation and proliferation of vascular endothelial cells therefore an important component atherosclerotic vessels. Inhibition MMP-2 activity associated with improvement cardiac function animal models after myocardial infarction. single nucleotide polymorphisms (SNPs) might alter expression influence prognosis patients symptomatic coronary artery disease (CAD). Methods results Genotyping for selected SNPs variants...