A5075754000- Cutaneous Melanoma Detection and Management
- Nonmelanoma Skin Cancer Studies
- Melanoma and MAPK Pathways
- Cancer Immunotherapy and Biomarkers
- Dermatologic Treatments and Research
- Cardiac and Coronary Surgery Techniques
- Dermatology and Skin Diseases
- Infective Endocarditis Diagnosis and Management
- AI in cancer detection
- Cardiac, Anesthesia and Surgical Outcomes
- Immunotherapy and Immune Responses
- Cardiac Valve Diseases and Treatments
- CAR-T cell therapy research
- Wound Healing and Treatments
- Polyomavirus and related diseases
- Psoriasis: Treatment and Pathogenesis
- Medical and Health Sciences Research
- Acne and Rosacea Treatments and Effects
- Aortic Disease and Treatment Approaches
- Atrial Fibrillation Management and Outcomes
- Autoimmune Bullous Skin Diseases
- Ocular Oncology and Treatments
- Asthma and respiratory diseases
- Full-Duplex Wireless Communications
- Antifungal resistance and susceptibility
University Hospital Schleswig-Holstein
2011-2025
University of Lübeck
2011-2025
University of Rostock
2020-2025
University Medical Center
2025
Heidelberg University
2019-2024
University Hospital Heidelberg
2019-2024
Universitätsmedizin Rostock
2020-2024
Universitätsklinikum Würzburg
2014-2023
Clinical Research Center Kiel
2021
German Marine Research Consortium
2020
Immune checkpoint inhibition and in particular anti-PD-1 immunotherapy have revolutionized the treatment of advanced melanoma. In this regard, higher tumoral PD-L1 protein (gene name: CD274) expression is associated with better clinical response increased survival to therapy. Moreover, there increasing evidence that tumor suppressor proteins are involved immune regulation capable modulating proteins. Here, we determined role p53 TP53) melanoma.We analyzed publicly available mRNA data from...
Immune checkpoint blockade therapy is beneficial and even curative for some cancer patients. However, the majority don't respond to immune therapy. Across different tumor types, pre-existing T cell infiltrates predict response checkpoint-based immunotherapy. Based on in vitro pharmacological studies, mouse models analyses of human melanoma patients, we show that cytokine GDF-15 impairs LFA-1/β2-integrin-mediated adhesion cells activated endothelial cells, which a pre-requisite extravasation....
Programmed death-1 (PD-1) antibodies and BRAF + MEK inhibitors are widely used for adjuvant therapy of fully resected high-risk melanoma. Little is known about treatment efficacy outside phase III trials. This real-world study reports on clinical outcomes modern melanoma in specialized skin cancer centers Germany, Austria Switzerland.Multicenter, retrospective investigating stage III-IV patients receiving nivolumab (NIV), pembrolizumab (PEM) or dabrafenib trametinib (D T) between 1/2017...
Cold atmospheric plasma (CAP) has positive effects on wound healing and antimicrobial properties. However, an ongoing challenge is the development of specific modes application for different clinical indications.We investigated in a prospective pilot study response tolerability newly developed CAP dressing acute split skin graft donor sites compared to conventional therapy.We applied both treatments each patient (n = 10) 7 days measured 4 parameters every other day (i.e., 1,440 measurements)...
<title>Abstract</title> <bold>Background: </bold>Shame is a complex emotion with different facets. Skin shame specific aspect of body shame, which involves the skin perceived as inferior or flawed. Its role in atopic dermatitis (AD) and psoriasis not well investigated. <bold>Objectives: </bold>This explorative study pursued three objectives: First, comparative analysis its facets AD psoriasis. Second, association other facets, depression, anxiety. Third, exploration unique impact on quality...
Abstract Shame is a complex emotion with different facets. Skin shame specific aspect of body shame, which involves the skin perceived as inferior or flawed. Its role in atopic dermatitis (AD) and psoriasis not well investigated. This explorative study pursued three objectives: First, comparative analysis its facets AD psoriasis. Second, association other facets, depression, anxiety. Third, exploration unique impact on quality life (QoL) patients. cross-sectional online survey encompassing...
Health-related quality of life (HRQoL) is reduced in atopic dermatitis and psoriasis. Several factors impact HRQoL including sociodemographic skin disease-related characteristics, health behaviours, cardiometabolic comorbidities, psychological conditions. However, their differential unique effects on are not well studied. In this cross-sectional online survey, adult patients with (n = 155) or psoriasis 246) provided data features respective diseases, comorbidities. Validated self-report...
Abstract Background Immune checkpoint inhibitors (ICI) have led to a prolongation of progression-free and overall survival in patients with metastatic Merkel cell carcinoma (MCC). However, immune-mediated adverse events due ICI therapy are common often lead treatment discontinuation. The response duration after cessation is unknown. Hence, this study aimed investigate the time relapse discontinuation MCC patients. Methods We analyzed 20 who been retrospectively enrolled at eleven skin cancer...
Psoriasis is a common skin disorder with high physical and psychological burden for patients. Up to 30% of the patients are candidates systemic treatment. The aim this study was describe characteristics real-world treatment psoriasis patients.This based on German medical claims data. A cross-sectional analysis observed all in 2020. longitudinal conducted, addressing who newly started treatment.In total, 116,507 prevalent 13,449 treated were followed. Of patients, 15.2% received 2020 (8.7%...
Ziel/Aim: Chronische Infektionen kardialer Implantate sind eine klinische Herausforderung. Bei fehlenden chirurgischen Sanierungsmöglichkeiten bleibt die palliative antibiotische Langzeitsuppression der Infektion einzige Therapieoption. Hierbei stellt i.v.-Applikation des Depotantibiotikums Dalbavancin aufgrund seiner langen Halbwertzeit (ca. 346 h) ein bisher wenig genutztes Potential dar und ermöglicht weitgehend ambulante Therapie für schwerkranke Patienten.
Abstract Background PD‐1 or BRAF + MEK inhibition is considered the current gold standard in adjuvant melanoma therapy. Little known if, after recurrence of disease and surgery, a second course therapy might be beneficial. Methods A multicenter, retrospective study investigating surgery stage III–IV patients. Patients received nivolumab (NIV), pembrolizumab (PEM) dabrafenib plus trametinib (D T) between 01/2017 10/2021. The primary endpoint was 12‐month recurrence‐free survival (RFS2)....
Patient-centered motives and expectations of the treatment actinic keratoses (AK) have received little attention until now. Hence, we aimed to profile cluster motivations among patients with AK in a nationwide multicenter, cross-sectional study including from 14 German skin cancer centers. Patients were asked complete self-administered questionnaire. Treatment towards management measured on visual analogue scale 1-10. Specific patient profiles investigated subgroup correlation analysis....
Abstract Introduction Acute aortic dissection Type A (AADA) is still associated with a high mortality rate and frequent postoperative complications. This study was designed to evaluate the risk factors for in AADA patients. Patients Methods retrospective analysis included 344 consecutive patients who underwent surgery moderate hypothermic circulatory arrest (20–24°C nasopharyngeal) between 2001 2016. Results The 30-day 18%. Nonsurvivors were significantly older (65.7 ± 12.0 years vs. 62.0...
Increasing knowledge of cancer genomes has triggered the development specific targeted inhibitors, thus providing a valuable therapeutic pool.In this report, authors analyze presence targetable alterations in 136 tumor samples from 92 patients with melanoma using comprehensive approach based on DNA sequencing and supported by RNA protein analysis. Three topics high clinical relevance are addressed: identification rare, activating alterations; detection patient-specific, co-occurring single...
Objective: Growth factor gene therapy represents one current approach in the of myocardial ischemia. We assessed vitro and vivo expression naked plasmid DNA aiming at preservation function a chronically ischemic model. Methods: In vitro: Primary cardiac fibroblasts were transfected with plasmids encoding enhanced green fluorescent protein, human VEGF121, FGF-2, or porcine MCP-1. Protein synthesis was microscopically, by ELISA, Western blotting, intracellular immunofluorescence. vivo: A LAD...
Rosacea is a common, facial, chronic inflammatory skin disease. Due to its complex pathogenesis, adequate therapy of rosacea can be challenging. An innovative recent therapeutic tool cold atmospheric plasma (CAP), which already established in the treatment wounds and promising different other diseases.In split-face pilot study we investigated dielectric-barrier-discharged CAP erythemato-telangiectatic (ETR) and/or papulopustular (PPR). was applied on lesional randomized side once daily (90...
Nonmelanoma skin cancer (NMSC) is the most frequent malignancy. Surgical intervention common treatment but may lead to disappointing results; alternative options are needed.In this monocentric pilot study, topical 188Re resin was investigated as a for invasive NMSC up 3-mm thickness. Twenty-two patients with 40 histologically confirmed NMSCs median size of 1.25 cm2 (range, 0.04-16.8 cm2) and tumor thickness 0.35 mm 0.1-2.1 mm) were included. Patients treated once targeted dose 50 Gy. The...
Most patients with advanced melanomas have a known primary site [melanoma of (MKP)]. However, 2%-9% are diagnosed melanoma metastasis unknown (MUP). As MUP and MKP similar UV-induced mutations molecular signatures, it is proposed that the tumor has regressed completely in MUP. regression could be indicative enhanced recognition antigens, we hypothesize better outcome compared MKP.Patients from 10 German university hospitals were retrospectively analyzed matched based on type systemic...
Abstract Significant progress has been made in the treatment of advanced Merkel cell carcinoma (MCC) by establishing immune checkpoint inhibitors (ICI). Tumor progression, durable response, or adverse events may lead to ICI discontinuation MCC patients. If these patients tumor progression occurs, question remains if re-induction with achieves renewed response. This retrospective multicenter study evaluated anti-PD-1/anti-PD-L1 therapy for MCC. Clinical data were extracted at initiation,...