A5014284729- Prostate Cancer Treatment and Research
- Medical Imaging Techniques and Applications
- Radiopharmaceutical Chemistry and Applications
- Radiomics and Machine Learning in Medical Imaging
- Prostate Cancer Diagnosis and Treatment
- Dementia and Cognitive Impairment Research
- Advanced MRI Techniques and Applications
- Alzheimer's disease research and treatments
- Functional Brain Connectivity Studies
- Advanced Radiotherapy Techniques
- Cardiac Imaging and Diagnostics
- Cancer, Lipids, and Metabolism
- Neuroendocrine Tumor Research Advances
- Lung Cancer Diagnosis and Treatment
- Glioma Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Neural and Behavioral Psychology Studies
- Neurobiology of Language and Bilingualism
- Gastric Cancer Management and Outcomes
- Radiation Dose and Imaging
- Esophageal Cancer Research and Treatment
- MRI in cancer diagnosis
- Bladder and Urothelial Cancer Treatments
- Cardiac Fibrosis and Remodeling
- Urologic and reproductive health conditions
University of Rostock
2016-2025
Monash Health
2025
Universitätsmedizin Rostock
2013-2024
Klinik und Poliklinik für Nuklearmedizin
2013-2024
Memorial Sloan Kettering Cancer Center
2024
Mayo Clinic in Arizona
2024
Dana-Farber Cancer Institute
2024
University Hospital Münster
2024
Indiana University – Purdue University Indianapolis
2024
Université Paris-Saclay
2024
The purpose of these guidelines is to assist physicians in recommending, performing, interpreting and reporting the results FDG PET/CT for oncological imaging adult patients. PET a quantitative technique therefore requires common quality control (QC)/quality assurance (QA) procedure maintain accuracy precision quantitation. Repeatability reproducibility are two essential requirements any measurement and/or biomarker. relates uncertainty obtaining same result patient when he or she examined...
Metastatic castration-resistant prostate cancer remains fatal despite recent advances. Prostate-specific membrane antigen (PSMA) is highly expressed in metastatic cancer. Lutetium-177 (177Lu)–PSMA-617 a radioligand therapy that delivers beta-particle radiation to PSMA-expressing cells and the surrounding microenvironment.
The aim of this guideline is to provide a minimum standard for the acquisition and interpretation PET PET/CT scans with [18F]-fluorodeoxyglucose (FDG). This will therefore address general information about[18F]-fluorodeoxyglucose (FDG) positron emission tomography-computed tomography (PET/CT) provided help physician physicist assist carrying out,interpret, document quantitative FDG examinations,but concentrate on optimisation diagnostic quality information.
<sup>177</sup>Lu-labeled PSMA-617 is a promising new therapeutic agent for radioligand therapy (RLT) of patients with metastatic castration-resistant prostate cancer (mCRPC). Initiated by the German Society Nuclear Medicine, retrospective multicenter data analysis was started in 2015 to evaluate efficacy and safety <sup>177</sup>Lu-PSMA-617 large cohort patients. <b>Methods:</b> One hundred forty-five (median age, 73 y; range, 43–88 y) mCRPC were treated 12 centers between February 2014 July...
Describes a fully-automatic three-dimensional (3-D)-segmentation technique for brain magnetic resonance (MR) images. By means of Markov random fields (MRF's) the segmentation algorithm captures three features that are special importance MR images, i.e., nonparametric distributions tissue intensities, neighborhood correlations, and signal inhomogeneities. Detailed simulations real images demonstrate performance algorithm. In particular, impact noise, inhomogeneity, smoothing, structure...
Here we aim to provide updated guidance and standards for the indication, acquisition, interpretation of PSMA PET/CT prostate cancer imaging. Procedures characteristics are reported a variety available small radioligands. Different scenarios clinical use PSMA-ligand discussed. This document provides clinicians technicians with best evidence, support implementation imaging in research routine practice.
In view of the commercial success integrated PET/CT scanners, there is an increasing interest in comparable SPECT/CT systems. SPECT combination with CT enables a direct correlation anatomic information and functional information, resulting better localization definition scintigraphic findings. Besides referencing, added value coregistration based on attenuation correction capabilities CT. The number clinical studies limited, but pilot have indicated higher specificity significant reduction...
Abstract We have determined the ability of positron emission tomography (PET) with thymidine analogue 3′-deoxy-3′-[18F]fluorothymidine (FLT) to detect manifestation sites malignant lymphoma, assess proliferative activity, and differentiate aggressive from indolent tumors. In this prospective study, FLT-PET was done additionally routine staging procedures in 34 patients lymphoma. Sixty minutes after i.v. injection ∼330 MBq FLT, transmission scanning done. Tracer uptake lymphoma evaluated...
Abstract A heterozygous R1101K mutation of the p150 subunit dynactin (DCTN1) is reported in a family with amyotrophic lateral sclerosis (ALS) and co‐occurrence frontotemporal dementia (FTD). Two members our kindred were affected motor neuron disease two an autosomal dominant pattern inheritance. We excluded involvement ALS FTD‐linked genes for copper/zinc superoxide dismutase (SOD1) tau. The sequence alteration DCTN1 gene may predispose subjects to FTD. Ann Neurol 2005;58:777–780
Previous studies demonstrated that chemotherapy-induced changes in tumor glucose metabolism measured with <sup>18</sup>F-FDG PET identify patients who benefit from preoperative chemotherapy and those do not. The prognosis for metabolic nonresponders is poorer than responders. Therefore, we initiated this prospective trial to improve the clinical outcome of using a salvage neoadjuvant radiochemotherapy. <b>Methods:</b> Fifty-six locally advanced adenocarcinomas esophagogastric junction were...
In this retrospective feasibility study diffusion-weighted magnetic resonance imaging (DWI) was evaluated as a potential tool for characterization of pelvic lymph nodes in patients with prostate cancer.Twenty-nine cancer underwent DWI the pelvis at 1.5T by non breath-hold SSEPI sequence using body phased array coil b values 50, 300, and 600 s/mm(2) an additional T2-weighted sequence. A total 118 (>6 mm short axis) were analyzed measuring ADC-value polygon region interest. Feasibility...
18F-FDG PET plays an increasing role in diagnosis and management planning of head neck cancer. Hybrid PET/CT has promoted the field molecular imaging This modality is particular relevant region, given complex anatomy variable physiologic FDG uptake patterns. The vast majority applications cancer related to squamous cell carcinoma. Clinical include distant metastases, identification synchronous 2nd primaries, detection carcinoma unknown primary residual or recurrent disease. Emerging are...
From 2010 until July 2016, the EANM Research Ltd. (EARL) FDG-PET/CT accreditation program has collected over 2500 phantom datasets from approximately 200 systems and 150 imaging sites worldwide. The objective of this study is to report findings impact on participating PET/CT systems.To obtain maintain EARL accredited status, were required complete submit two scans - calibration quality control (CalQC), using a uniform cylindrical image (IQQC), NEMA NU2-2007 body phantom. Average volumetric...