A5046050028- Neuroinflammation and Neurodegeneration Mechanisms
- Traumatic Brain Injury and Neurovascular Disturbances
- Acute Ischemic Stroke Management
- Optical Imaging and Spectroscopy Techniques
- Animal testing and alternatives
- Meta-analysis and systematic reviews
- Neuroscience and Neuropharmacology Research
- Advanced MRI Techniques and Applications
- Neurological Disease Mechanisms and Treatments
- Nitric Oxide and Endothelin Effects
- Barrier Structure and Function Studies
- Non-Invasive Vital Sign Monitoring
- Health and Medical Research Impacts
- Ethics in Clinical Research
- Anesthesia and Neurotoxicity Research
- Stroke Rehabilitation and Recovery
- Neurological Disorders and Treatments
- S100 Proteins and Annexins
- Mitochondrial Function and Pathology
- Immune Response and Inflammation
- Migraine and Headache Studies
- Bacterial Infections and Vaccines
- Intracranial Aneurysms: Treatment and Complications
- Cerebrovascular and Carotid Artery Diseases
- Health Systems, Economic Evaluations, Quality of Life
Charité - Universitätsmedizin Berlin
2016-2025
Humboldt-Universität zu Berlin
2009-2025
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2016-2025
Freie Universität Berlin
1996-2025
German Center for Neurodegenerative Diseases
2014-2024
German Centre for Cardiovascular Research
2013-2024
The Ohio State University Wexner Medical Center
2017-2023
Einstein Center for Neurosciences Berlin
2009-2023
University Hospital of Basel
2022
University of Basel
2022
Reproducible science requires transparent reporting. The ARRIVE guidelines (Animal Research: Reporting of In Vivo Experiments) were originally developed in 2010 to improve the reporting animal research. They consist a checklist information include publications describing vivo experiments enable others scrutinise work adequately, evaluate its methodological rigour, and reproduce methods results. Despite considerable levels endorsement by funders journals over years, adherence has been...
Improving the reproducibility of biomedical research is a major challenge. Transparent and accurate reporting vital to this process; it allows readers assess reliability findings repeat or build upon work other researchers. The ARRIVE guidelines (Animal Research: Reporting In Vivo Experiments) were developed in 2010 help authors journals identify minimum information necessary report publications describing vivo experiments. Despite widespread endorsement by scientific community, impact on...
Reproducible science requires transparent reporting. The ARRIVE guidelines (Animal Research: Reporting of In Vivo Experiments) were originally developed in 2010 to improve the reporting animal research. They consist a checklist information include publications describing vivo experiments enable others scrutinise work adequately, evaluate its methodological rigour, and reproduce methods results. Despite considerable levels endorsement by funders journals over years, adherence has been...
Infections are a leading cause of death in stroke patients. In mouse model focal cerebral ischemia, we tested the hypothesis that stroke-induced immunodeficiency increases susceptibility to bacterial infections. 3 d after all animals developed spontaneous septicemia and pneumonia. Stroke induced an extensive apoptotic loss lymphocytes shift from T helper cell (Th)1 Th2 cytokine production. Adoptive transfer natural killer cells wild-type mice, but not interferon (IFN)-γ–deficient or...
Reproducible science requires transparent reporting. The ARRIVE guidelines (Animal Research: Reporting of In Vivo Experiments) were originally developed in 2010 to improve the reporting animal research. They consist a checklist information include publications describing vivo experiments enable others scrutinise work adequately, evaluate its methodological rigour, and reproduce methods results. Despite considerable levels endorsement by funders journals over years, adherence has been...
The term cortical spreading depolarization (CSD) describes a wave of mass neuronal associated with net influx cations and water. Clusters prolonged CSDs were measured time-locked to progressive ischaemic damage in human cortex. CSD induces tone alterations resistance vessels, causing either transient hyperperfusion (physiological haemodynamic response) healthy tissue; or hypoperfusion [inverse response = ischaemia (CSI)] tissue at risk for damage, which has so far only been shown...
Laser-Doppler flowmetry (LDF), a new method allowing instantaneous, continuous, and noninvasive measurements of microcirculatory blood flow in small tissue sample, was evaluated for its accuracy monitoring regional cerebral (rCBF) the cortical microcirculation after focal ischemia. Wistar spontaneously hypertensive rats (SHR, n = 19) were subjected to permanent occlusion middle common carotid arteries. Absolute rCBF sample ischemic hemisphere measured autoradiographically with [ 14...
Background— Estrogens improve endothelial function and accelerate reendothelialization after vascular injury via largely unknown mechanisms. Bone marrow–derived progenitor cells (EPCs) are thought to positively influence endothelialization, repair, angiogenesis. Methods Results— In mice subjected sham operation, ovariectomy, or ovariectomy estrogen replacement treatment, deficiency significantly decreased EPCs circulating in the peripheral blood residing bone marrow, as well that were vitro...
Changes in cerebral blood oxygenation due to functional activation of the primary sensorimotor cortex during a unilateral finger opposition task were simultaneously mapped by deoxyhemoglobin-sensitive magnetic resonance imaging (MRI) and monitored near-infrared spectroscopy (NIRS). Activation foci along contralateral central sulcus displayed task-associated increases MRI signal intensity, indicating concomitant decrease focal concentration deoxyhemoglobin. This interpretation was confirmed...
Modern functional neuroimaging methods, such as positron-emission tomography (PET), optical imaging of intrinsic signals, and MRI (fMRI) utilize activity-dependent hemodynamic changes to obtain indirect maps the evoked electrical activity in brain. Whereas PET flow-sensitive map cerebral blood flow (CBF) changes, oxygenation level-dependent areas with concentration deoxygenated hemoglobin (HbR). However, relationship between CBF HbR during activation has never been tested experimentally....
Stroke affects the normally well-balanced interplay of 2 supersystems: nervous and immune system. Recent research elucidated some involved signals mechanisms and, importantly, was able to demonstrate that brain-immune interactions are highly relevant for functional outcome after stroke. Immunodepression stroke increases susceptibility infection, most complication in patients. However, immunodepression may also have beneficial effects, example, by suppressing autoaggressive responses during...
Atherosclerosis and restenosis after vascular injury are both characterized by endothelial dysfunction, apoptosis, inappropriate endothelialization, neointimal formation. Bone marrow-derived progenitor cells have been implicated in neovascularization, resulting adult blood vessel Despite the anticipated stem cell plasticity, role of bone has not clarified lesion development.We investigated formation mice transplantation marrow transfected means retrovirus with enhanced green fluorescent...