Matt Lechner
A5004594012- Head and Neck Surgical Oncology
- Olfactory and Sensory Function Studies
- Head and Neck Cancer Studies
- Sinusitis and nasal conditions
- Cervical Cancer and HPV Research
- Advanced Chemical Sensor Technologies
- Long-Term Effects of COVID-19
- Obstructive Sleep Apnea Research
- Nasal Surgery and Airway Studies
- Ear and Head Tumors
- Oral and Maxillofacial Pathology
- Salivary Gland Tumors Diagnosis and Treatment
- Bone Tumor Diagnosis and Treatments
- Allergic Rhinitis and Sensitization
- Epigenetics and DNA Methylation
- Esophageal Cancer Research and Treatment
- Neuroscience of respiration and sleep
- Cancer-related molecular mechanisms research
- Vestibular and auditory disorders
- Cancer Immunotherapy and Biomarkers
- Hearing, Cochlea, Tinnitus, Genetics
- Tracheal and airway disorders
- Glaucoma and retinal disorders
- Cancer Genomics and Diagnostics
- Lung Cancer Research Studies
CRUK Lung Cancer Centre of Excellence
2016-2025
University College London
2016-2025
University of East Anglia
2024
University College London Hospitals NHS Foundation Trust
2013-2024
National Hospital for Neurology and Neurosurgery
2024
Cancer Institute (WIA)
2016-2024
Barts Health NHS Trust
2019-2023
Homerton University Hospital NHS Foundation Trust
2023
Stanford University
2020-2023
Royal London Hospital
2016-2022
Abstract Gains and losses of DNA are prevalent in cancer emerge as a consequence inter-related processes replication stress, mitotic errors, spindle multipolarity breakage–fusion–bridge cycles, among others, which may lead to chromosomal instability aneuploidy 1,2 . These copy number alterations contribute initiation, progression therapeutic resistance 3–5 Here we present conceptual framework examine the patterns human that is widely applicable diverse data types, including whole-genome...
Abstract The nature and extent of immune cell infiltration into solid tumours are key determinants therapeutic response. Here, using a DNA methylation-based approach to tumour fraction deconvolution, we report the integrated analysis composition genomics across wide spectrum cancers. Initially studying head neck squamous carcinoma, identify two distinct subgroups: ‘immune hot’ cold’, which display differing prognosis, mutation burden, cytokine signalling, cytolytic activity oncogenic driver...
Bulk-tissue DNA methylomes represent an average over many different cell types, hampering our understanding of cell-type-specific contributions to disease development. As single-cell methylomics is not scalable large cohorts individuals, cost-effective computational solutions are needed, yet current methods limited tissues such as blood. Here we leverage the high-resolution nature tissue-specific RNA-sequencing datasets construct a methylation atlas defined for 13 solid tissue types and 40...
Background: Since publication of the original Position Paper on Olfactory Dysfunction in 2017 (PPOD-17), personal and so- cietal burden olfactory disorders has come sharply into focus through lens COVID-19 pandemic. Clinicians, scientists public are now more aware importance olfaction, impact its dysfunction quality life, nutrition, social relationships mental health. Accordingly, new basic, translational clinical research resulted significant pro- gress since PPOD-17. In this updated...
The diagnosis of sinonasal tumors is challenging due to a heterogeneous spectrum various differential diagnoses as well poorly defined, disputed entities such undifferentiated carcinomas (SNUCs). In this study, we apply machine learning algorithm based on DNA methylation patterns classify with clinical-grade reliability. We further show that SNUC morphology are not their current terminology suggests but rather reassigned four distinct molecular classes defined by epigenetic, mutational and...
Abstract Nasopharyngeal cancer (NPC), endemic in Southeast Asia, lacks effective diagnostic and therapeutic strategies. Even high-income countries the 5-year survival rate for stage IV NPC is less than 40%. Here we report high somatostatin receptor 2 (SSTR2) expression multiple clinical cohorts comprising 402 primary, locally recurrent metastatic NPCs. We show that SSTR2 induced by Epstein–Barr virus (EBV) latent membrane protein 1 (LMP1) via NF-κB pathway. Using cell-based preclinical...
Abstract Background Loss of smell and/or taste are cardinal symptoms COVID-19. ‘Long-COVID’, persistence symptoms, affects around one fifth people. However, data regarding the clinical resolution loss lacking. In this study we assess and at 4–6 week follow-up, aim to identify risk factors for persistent describe as a feature long-COVID in community cohort London with known SARS-CoV-2 IgG/IgM antibody status. We also compare subjective objective assessments subset participants. Methods Four...
Human papillomavirus (HPV)-associated cervical cancer is a leading cause of deaths in women. Here we present an integrated multi-omic analysis 643 squamous cell carcinomas (CSCC, the most common histological variant cancer), representing patient populations from USA, Europe and Sub-Saharan Africa identify two CSCC subtypes (C1 C2) with differing prognosis. C1 C2 tumours can be driven by either HPV types (16 18) while HPV16 HPV18 are overrepresented among respectively, prognostic difference...
Objectives It has been demonstrated that reduction in smell and/or taste is the most predictive symptom SARS-CoV-2/Covid-19 infection. We used Google Trends to analyze regional searches relating loss of and across Italy, Spain, France, Brazil, United States America determined association with reported Covid-19 cases.
Abstract Objectives Sinonasal mucosal melanoma (SNMM) is an extremely rare and challenging sinonasal malignancy with a poor prognosis. Standard treatment involves complete surgical resection, but the role of adjuvant therapy remains unclear. Crucially, our understanding its clinical presentation, course, optimal limited, few advancements in improving management have been made recent past. Methods We conducted international multicenter retrospective analysis 505 SNMM cases from 11...
Background: Olfactory dysfunction is a cardinal symptom of COVID-19 infection, however, studies assessing long-term olfactory are limited and no randomised-controlled trials (RCTs) early training have been conducted. Methodology: We conducted prospective, multi-centre study consisting baseline psychophysical measurements smell taste function. Eligible participants were further recruited into 12-week RCT versus control (safety information). Patient-reported outcomes measured using an...