A5014205200- Diet and metabolism studies
- Bariatric Surgery and Outcomes
- Olfactory and Sensory Function Studies
- Long-Term Effects of COVID-19
- Regulation of Appetite and Obesity
- Diabetes Treatment and Management
- Obesity and Health Practices
- Eating Disorders and Behaviors
- Advanced Chemical Sensor Technologies
- Pharmacology and Obesity Treatment
- Body Contouring and Surgery
- Dietary Effects on Health
- Gastric Cancer Management and Outcomes
- Endoplasmic Reticulum Stress and Disease
- Adipose Tissue and Metabolism
- Genetic factors in colorectal cancer
- Cardiovascular Disease and Adiposity
- Nutritional Studies and Diet
- Adrenal and Paraganglionic Tumors
- Cardiovascular Issues in Pregnancy
- Ion Transport and Channel Regulation
- Biochemical Analysis and Sensing Techniques
- Consumer Attitudes and Food Labeling
- Skin Protection and Aging
- Retinal Diseases and Treatments
University College Hospital
2016-2024
University College London
2016-2024
National Institute for Health Research
2016-2024
Barts Health NHS Trust
2024
University College London Hospitals NHS Foundation Trust
2024
Royal London Hospital
2024
National Health Service
2023
North Middlesex University Hospital NHS Trust
2016
Imperial College London
2016
North Shore Hospital
2016
Bariatric surgery is today the most effective long-term therapy for management of patients with severe obesity, and its use recommended by relevant guidelines obesity in adults. general safe effective, but it can cause new clinical problems associated specific diagnostic, preventive therapeutic needs. For clinicians, acquisition special knowledge skills required order to deliver appropriate care post-bariatric patient. In present recommendations, basic notions needed provide first-level...
Metabolic surgery leads to weight loss and improved health, but these outcomes are highly variable. Poor is associated with lower circulating levels of glucagon-like peptide-1 (GLP-1).To assess the efficacy safety GLP-1 receptor agonist, liraglutide, 3.0 mg, on percentage body reduction in patients poor suboptimal response after metabolic surgery.The Evaluation Liraglutide mg Patients With Weight Loss a Suboptimal Glucagon-Like Peptide-1 Response (BARI-OPTIMISE) randomized placebo-controlled...
Abstract Aims The comparative efficacy of Roux‐en‐Y gastric bypass (RYGB) and sleeve gastrectomy on Type 2 diabetes remission the role weight loss are unclear. DiaRem prediction score uses HbA 1c , age medications but not duration. aim this study was to compare with DiaBetter that includes duration, upon combined (complete plus partial) 2‐year post‐surgery in people following RYGB gastrectomy, investigate relationship between remission. Methods A retrospective single‐centre cohort obese who...
Olfactory impairments and anosmia from COVID-19 infection typically resolve within 2-4 weeks, although in some cases, symptoms persist longer. COVID-19-related is associated with olfactory bulb atrophy, however, the impact on cortical structures relatively unknown, particularly those long-term symptoms. In this exploratory, observational study, we studied individuals who experienced anosmia, or without recovered sense of smell, compared against no prior (confirmed by antibody testing, all...
Background Loss of smell and taste are commonly reported symptoms associated with coronavirus disease 2019 (COVID-19); however, the seroprevalence severe acute respiratory syndrome 2 (SARS-CoV-2) antibodies in people loss and/or is unknown. The study aimed to determine SARS-CoV-2 a community-based population compare frequency COVID-19 participants without antibodies. It also evaluated whether or indicative infection. Methods findings Text messages, sent via primary care centers London,...
Obesity constitutes a major global health threat. Despite the success of bariatric surgery in delivering sustainable weight loss and improvement obesity-related morbidity, effective non-surgical treatments are urgently needed, necessitating an increased understanding body regulation. Neuroimaging studies undertaken people with healthy weight, overweight, obesity following have contributed to identifying neurophysiological changes seen help increase our mechanisms driving favourable eating...
Abstract Background Loss of smell and/or taste are cardinal symptoms COVID-19. ‘Long-COVID’, persistence symptoms, affects around one fifth people. However, data regarding the clinical resolution loss lacking. In this study we assess and at 4–6 week follow-up, aim to identify risk factors for persistent describe as a feature long-COVID in community cohort London with known SARS-CoV-2 IgG/IgM antibody status. We also compare subjective objective assessments subset participants. Methods Four...
Introduction Obesity increases the risk of morbidity and mortality. A major driver has been increased availability ultra-processed food (UPF), now main UK dietary energy source. The Eatwell Guide (EWG) provides public guidance for a healthy balanced diet but offers no UPF guidance. Whether can largely consist UPFs is unclear. No study assessed whether health impact adhering to guidelines depends on processing. Furthermore, our will assess 6-month behavioural support programme aimed at...
Abstract Context There are limited comparative studies between one-anastomosis gastric bypass (OAGB) vs Roux-en-Y (RYGB) and sleeve gastrectomy (SG) on body composition musculoskeletal health. Objective To compare changes in composition, areal bone mineral density (aBMD), muscle strength, physical function the first year following OAGB, RYGB, SG within a UK-based healthcare setting. Methods This is secondary analysis of BARI-LIFESTYLE trial 119 adults (77% women; mean ± SD age 45.9 10.3...
Type 2 diabetes (T2D) is one of the most significant and fast-growing health challenges 21st century. Despite variety available glucose-lowering agents, many patients do not attain or maintain adequate glycaemic control. Bariatric surgery demonstrates a profound anti-diabetic effect, which almost immediate weight-loss independent. The improvement in after bariatric together with endoscopic accessibility duodenum has led to development new metabolic procedures that capitalise on importance...
Abstract High altitude residents have a lower incidence of type 2 diabetes mellitus (T2DM). Therefore, we examined the effect repeated overnight normobaric hypoxic exposure on glycaemic control, appetite, gut microbiota and inflammation in adults with T2DM. Thirteen T2DM [glycated haemoglobin (HbA1 c ): 61.1 ± 14.1 mmol mol −1 ; aged 64.2 9.4 years; four female] completed single‐blind, randomised, sham‐controlled, cross‐over study for 10 nights, sleeping when exposed to hypoxia (fractional...
Abstract ‘Hedonic hunger’ indicates the desire to consume food in absence of an energy requirement. Hedonic hunger can be investigated using validated Power Food Scale (PFS). Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) are currently most effective treatment options for severe obesity. Following RYGB, hedonic diminishes, which may contribute sustained weight loss. There no data examining effect SG on hunger. We prospectively evaluated PFS patients with obesity prior 6 months...
The quantity and appearance of dense breast tissue in mammograms is related to the risk developing cancer, sensitivity mammographic interpretation, likelihood local recurrence cancer following surgery. Visual assessment density widely used, often with readers indicating percentage a mammogram. Although real can be used investigate intra- inter-observer variability, ground truth difficult ascertain, so reader accuracy, we created 60 synthetic, mammogram-like images densities comparable area...