A5001580002- Bone health and osteoporosis research
- Bone fractures and treatments
- Nutrition and Health in Aging
- Hip and Femur Fractures
- Ultrasound and Hyperthermia Applications
- Muscle Physiology and Disorders
- Tendon Structure and Treatment
- Bone Metabolism and Diseases
- Effects of Vibration on Health
- Scoliosis diagnosis and treatment
- Pelvic and Acetabular Injuries
- Orthopedic Infections and Treatments
- Body Composition Measurement Techniques
- Shoulder Injury and Treatment
- Orthopaedic implants and arthroplasty
- Bone and Joint Diseases
- Cardiac, Anesthesia and Surgical Outcomes
- Bone health and treatments
- Cerebral Palsy and Movement Disorders
- Spinal Fractures and Fixation Techniques
- Total Knee Arthroplasty Outcomes
- Laser Applications in Dentistry and Medicine
- Noise Effects and Management
- Bone Tissue Engineering Materials
- Estrogen and related hormone effects
Chinese University of Hong Kong
2016-2025
Prince of Wales Hospital
2012-2024
Marymount University
2022
Chinese University of Hong Kong, Shenzhen
2015-2021
Hospital Authority
2018
Shenzhen Institutes of Advanced Technology
2012-2017
Chinese Academy of Sciences
2012-2017
University College London
2015-2017
University College Hospital
2015-2017
Nanjing University
2016
Background Elderly people with low lean and high fat mass, are diagnosed sarcopenic obesity (SO), often have poor clinical outcomes. This study aimed to explore the relationship between sarcopenia, optimal proportion of muscle for old individuals. Methods Participants aged 60 years or above were instructed perform bioelectrical impedance analysis obtain indicators, handgrip strength was also performed. Sarcopenia according predicted appendicular skeletal mass function. Body index (BMI) body...
Low intensity pulsed ultrasound (LIPUS) has been proven effective in promoting fracture healing but the underlying mechanisms are not fully depicted. We examined effect of LIPUS on recruitment mesenchymal stem cells (MSCs) and pivotal role stromal cell-derived factor-1/C-X-C chemokine receptor type 4 (SDF-1/CXCR4) pathway response to stimulation, which essential factors bone healing. For vitro study, isolated rat MSCs were divided into control or group. treatment was given 20 minutes/day at...
Abstract Aims The comparative efficacy of Roux‐en‐Y gastric bypass (RYGB) and sleeve gastrectomy on Type 2 diabetes remission the role weight loss are unclear. DiaRem prediction score uses HbA 1c , age medications but not duration. aim this study was to compare with DiaBetter that includes duration, upon combined (complete plus partial) 2‐year post‐surgery in people following RYGB gastrectomy, investigate relationship between remission. Methods A retrospective single‐centre cohort obese who...
Abstract Background This study aimed to adjust and cross‐validate skeletal muscle mass measurements between bioimpedance analysis (BIA) dual‐energy X‐ray absorptiometry (DXA) for the screening of sarcopenia in community estimate prevalence Hong Kong. Methods Screening was provided community‐dwelling older adults. Appendicular (ASM) evaluated by BIA (InBody 120 or 720) and/or DXA. Handgrip strength gait speed were assessed. Diagnosis based on 2019 revised Asian Working Group Sarcopenia...
The effect of low intensity pulsed ultrasound on human periosteal cells was investigated. Normal periosteum obtained to culture the cells. After characterization, cultures at Days 2 and 4 were treated with for 5, 10, 20 minutes respectively. Assessments done assess total number viable cells, cell proliferation, alkaline phosphatase activity, osteocalcin secretion, vascular endothelial growth factor expression, calcium nodule formation. With not as control, results showed that did affect It...
Fracture healing is a biological regenerative process that follows well-orchestrated sequence. Most uneventful and enhancement of normal fracture not commonly done, although it clinically important in the recovery regain functions after fracture. This study investigated osteogenic effect low-magnitude high-frequency vibration (LMHFV, 35 Hz, 0.3 g) on rats with closed femoral shaft by comparing sham-treated control. Assessments plain radiography, micro-CT as well histomorphometry showed...
Background: This retrospective cohort study aims to investigate the impact of regular pre- and postoperative geriatric input into management patients with hip fracture, specific interests in morbidity mortality. Methods: Patients fracture (n = 548) older than 60 years were identified within a 2-year period. In first year, 270) managed mainly by orthopedics this group constituted control group. second (orthogeriatric group, n 278) had reviews orthopedic surgeons geriatricians (physicians...
BDNF produced by skeletal muscle in female mice enables switching of fuel sources during fasting.
Sarcopenia is an age-related systemic syndrome with progressive deterioration in skeletal muscle functions and loss mass.Although the senescence-accelerated mouse P8 (SAMP8) was reported valid for muscular ageing research, there no report on details such as sarcopenia onset time.Therefore, this study to investigate change of mass, structure during development sarcopenia.Besides average life span, structural functional measurements were also studied.Male SAMP8 animals examined at month 6, 7,...
Aims The effect of the gut microbiota (GM) and its metabolite on bone health is termed gut-bone axis. Multiple studies have elucidated mechanisms but findings vary greatly. A systematic review was performed to analyze current animal models explore GM bone. Methods Literature search PubMed Embase databases. Information types strains animals, induction osteoporosis, intervention strategies, determination GM, assessment mineral density (BMD) quality, key were extracted. Results total 30...