A5027448769- Bariatric Surgery and Outcomes
- Nutrition and Health in Aging
- Body Contouring and Surgery
- Diet and metabolism studies
- Vitamin D Research Studies
- Obesity and Health Practices
- Liver Disease Diagnosis and Treatment
- GDF15 and Related Biomarkers
- Liver Disease and Transplantation
- Dietary Effects on Health
- Pharmaceutical Economics and Policy
- Regulation of Appetite and Obesity
- Physical Activity and Health
- Antibiotic Use and Resistance
- Obesity, Physical Activity, Diet
- Cardiovascular Disease and Adiposity
- Pharmacology and Obesity Treatment
- Body Composition Measurement Techniques
- Alcohol Consumption and Health Effects
- Diet, Metabolism, and Disease
- Diabetes Treatment and Management
- Liver Diseases and Immunity
- Pharmaceutical studies and practices
- Clinical Nutrition and Gastroenterology
University College London
2018-2024
Siriraj Hospital
2017-2024
Mahidol University
2017-2024
University College London Hospitals NHS Foundation Trust
2021-2024
National Institute for Health Research
2021-2024
Royal London Hospital
2018
This randomized trial aimed to compare the effects of moderate-intensity aerobic vs resistance exercise with dietary modification in patients nonalcoholic fatty liver disease (NAFLD).Patients NAFLD were randomly assigned (1:1) a 12-week supervised training program or intervention consisting monthly individual nutritional counseling by dietician. Transient elastography, anthropometry, body composition, cardiorespiratory fitness, biochemistries, and glucose tolerance measured at baseline 12...
Abstract Objective The study's aim was to investigate the impact of a 12‐month adjunctive lifestyle intervention on weight loss and health outcomes after bariatric surgery. Methods A total 153 participants (78.4% females; mean [SD], age 44.2 [10.6] years; BMI 42.4 [5.7] kg/m 2 ) were randomized ( n = 79) control 74). BARI‐LIFESTYLE program combined 17 nutritional‐behavioral tele‐counseling sessions plus once‐weekly supervised exercise for 12 weeks. primary outcome percentage at 6 months post...
Abstract Background/Objectives There have been no studies examining the efficacy of meal replacement (MR) on weight loss and metabolic syndrome (MS) improvement in Southeast Asians. Thus, we undertook a 12-week randomised trial to evaluate effect lifestyle education intervention alone (LEI) or with partial MR (LEI + MR) obese Thai adults MS. Subjects/Methods A total 110 patients were receive either LEI MR. Both groups received achieve loss. group additionally two daily replace breakfast,...
Dietary modification is essential for treating nonalcoholic fatty liver disease (NAFLD); however, the dietary components are less well defined. We enrolled 252 adults with no history of and excessive alcohol use to evaluate relationship between macronutrients NAFLD insulin resistance. Participants took photographs their meals documented food intake in a diary seven consecutive days. A dietitian estimated type portion size items analyzed nutrients INMUCAL-Nutrients software. Later,...
Summary The BARI‐LIFESTYLE trial is a randomized controlled evaluating the efficacy of post‐surgery nutritional and behavioural tele‐counselling, supervised exercise programme to maximize health benefits bariatric surgery. Due coronavirus disease 2019 (COVID‐19) pandemic, in‐person component had be converted remote tele‐exercise. However, patients' acceptability this method provision unknown. Between 3 6 months following surgery, 13 adults participated in weekly, structured, 60‐min classes...
Abstract Context There are limited comparative studies between one-anastomosis gastric bypass (OAGB) vs Roux-en-Y (RYGB) and sleeve gastrectomy (SG) on body composition musculoskeletal health. Objective To compare changes in composition, areal bone mineral density (aBMD), muscle strength, physical function the first year following OAGB, RYGB, SG within a UK-based healthcare setting. Methods This is secondary analysis of BARI-LIFESTYLE trial 119 adults (77% women; mean ± SD age 45.9 10.3...
Introduction Roux-en-Y gastric bypass and sleeve gastrectomy are the two most common bariatric surgery performed in UK that result comparable weight loss remission of obesity-associated comorbidities. However, there is a paucity studies examining impact these procedures on body composition, physical activity levels, sedentary behaviour, function strength, dietary intake, health-related quality life costs. Methods analysis The BARI-LIFESTYLE observational study 1-year prospective,...
Emerging evidence revealed that brain-derived neurotrophic factor (BDNF), secreted protein acidic and rich in cysteine (SPARC), fibroblast growth 21(FGF-21) differentiation 15 (GDF-15) are involved energy metabolism body weight regulation. Our study aimed at examining their association with BMI, alterations after anti-obesity treatments, 1-year loss.A prospective observational of 171 participants overweight obesity 46 lean controls was established. All received lifestyle educational...
Remission of type 2 diabetes (T2D) can be achieved by many, but not all, people following bariatric/metabolic surgery. The mechanisms underlying T2D remission remain incompletely understood. This observational study aimed to identify novel weight-loss independent clinical, metabolic and genetic factors that associate with using comprehensive phenotyping.Ten patients without (non-remitters) were matched 10 (remitters) for age, sex, surgery, body weight, BMI, post-operative weight loss,...
Abstract Conclusions : This study highlights the association of SPARC, FGF-21, and GDF-15 levels with BMI. Decreased circulating FGF-21 were associated greater weight loss at 1 year regardless types anti-obesity modalities. Purpose Emerging evidence revealed that brain-derived neurotrophic factor(BDNF), secreted protein acidic rich in cysteine(SPARC), fibroblast growth factor 21(FGF-21) differentiation 15(GDF-15) are involved energy metabolism body regulation. Our aimed examining their BMI,...
Abstract Introduction One in 5 people have a suboptimal weight-loss (WL) response to bariatric surgery. The causes are unclear, but patients report resumed hunger and increased food intake, eating behaviours driven by the orexigenic hormone, ghrelin. This proof-of-concept study aimed evaluate impact of reducing circulating acyl-ghrelin, biologically active isoform, on appetite energy intake with WL aberrant ghrelin profile after Methods Thirty-five <20%WL from 12 months Roux-en-Y...
Background: Bariatric surgery is the most effective weight loss treatment for people living with severe obesity. However, following surgery, and health benefits vary markedly between individuals, ability to adapt post-operative lifestyle changes implicated as a potential mediator. The BARI-LIFESTYLE trial investigated whether 12-month adjunctive post-surgery intervention programme compared usual standard care impacted upon outcomes.Methods: This single-blind, parallel-group, randomised...