A5079991156- Epilepsy research and treatment
- Advanced Causal Inference Techniques
- Health Systems, Economic Evaluations, Quality of Life
- Statistical Methods in Clinical Trials
- Statistical Methods and Inference
- Pharmacological Effects and Toxicity Studies
- EEG and Brain-Computer Interfaces
- Systemic Lupus Erythematosus Research
- Dementia and Cognitive Impairment Research
- Rheumatoid Arthritis Research and Therapies
- Geriatric Care and Nursing Homes
- Neurological disorders and treatments
- Neuroscience and Neuropharmacology Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Statistical Methods and Bayesian Inference
- Spondyloarthritis Studies and Treatments
- Botulinum Toxin and Related Neurological Disorders
- Cerebrospinal fluid and hydrocephalus
- Systemic Sclerosis and Related Diseases
- Fetal and Pediatric Neurological Disorders
- Advanced Neuroimaging Techniques and Applications
- Occupational Therapy Practice and Research
- Lipoproteins and Cardiovascular Health
- Glioma Diagnosis and Treatment
- Bone and Joint Diseases
University College London
2016-2025
University of Nottingham
2021-2025
London School of Hygiene & Tropical Medicine
2025
MRC Clinical Trials Unit at UCL
2016-2024
Tallaght University Hospital
2021-2023
National Hospital for Neurology and Neurosurgery
2023
Queen's University
2023
Epilepsy Society
2023
The University of Western Australia
2023
Newcastle University
2023
Objective. To determine nephritis outcomes in a prospective multi-ethnic/racial SLE inception cohort. Methods. Patients the Systemic Lupus International Collaborating Clinics cohort (≤15 months of diagnosis) were assessed annually for estimated glomerular filtration rate (eGFR), proteinuria and end-stage renal disease (ESRD). Health-related quality life was measured by Short Form (36 questions) health survey questionnaire (SF-36) subscales, mental physical component summary scores. Results....
<h3>Background and aims</h3> We studied damage accrual factors determining development progression of in an international cohort systemic lupus erythematosus (SLE) patients. <h3>Methods</h3> The Systemic Lupus International Collaborating Clinics (SLICC) Inception Cohort recruited patients within 15 months developing four or more 1997 American College Rheumatology (ACR) criteria for SLE; the SLICC/ACR index (SDI) was measured annually. assessed relative rates transition using maximum...
Objective. MTX is widely used to treat synovitis in PsA without supporting trial evidence. The aim of our study was test the value first large randomized placebo-controlled (RCT) PsA. Methods. A 6-month double-blind RCT compared (15 mg/week) with placebo active primary outcome response criteria (PsARC). Other outcomes included ACR20, DAS-28 and their individual components. Missing data were imputed using multiple imputation methods. Treatments logistic regression analysis (adjusted for age,...
<h3>Background</h3> JUUL is an electronic cigarette that aerosolises a nicotine-containing liquid, while IQOS heats tobacco to produce aerosol. Both are marketed smokers, but their effects have seldom been examined in this population. <h3>Methods</h3> Eighteen smokers (13 men) with no or experience completed within-subject, laboratory study assessing nicotine delivery and subjective after controlled (10 puffs, ~30 s interpuff interval) ad libitum (90 min) use of JUUL, own-brand (OB)...
To examine the frequency and characteristics of headaches their association with global disease activity health-related quality life (HRQOL) in patients systemic lupus erythematosus (SLE).A inception cohort was assessed annually for headache (5 types) 18 other neuropsychiatric (NP) events. Global scores (SLE Disease Activity Index 2000 [SLEDAI-2K]), damage (Systemic Lupus International Collaborating Clinics/American College Rheumatology Damage [SDI]), Short Form 36 (SF-36) mental physical...
Statins are widely prescribed for the primary prevention of cardiovascular disease. Guidelines exist statin prescriptions, but there is little recent analysis concerning prescription trends over time and how these vary with respect to demographic variables.Using The Health Improvement Network care database, therapy initiation prevalence rates were calculated using data from 7,027,711 individuals across UK years 1995 2013, overall stratified by sex, age group, socioeconomic deprivation level...
Summary Objective Surgical resection of the mesial temporal structures brings seizure remission in 65% individuals with drug‐resistant lobe epilepsy ( MTLE ). Laser interstitial thermal therapy (Li TT) is a novel that may provide minimally invasive means ablating similar outcomes, while minimizing damage to neocortex. Systematic trajectory planning helps ensure safety and optimal freedom through adequate ablation amygdalohippocampal complex AHC Previous studies have highlighted relationship...
In healthcare research, outcomes with skewed probability distributions are common. Sample size calculations for such typically based on estimates a transformed scale (e.g. log) which may sometimes be difficult to obtain. contrast, of median and variance the untransformed generally easier pre-specify. The aim this paper is describe how calculate sample two group comparison interest log-normal outcome data.A distribution data assumed calculation approach two-sample t-test that compares...
Background The START (STrAtegies for RelaTives) intervention reduced depressive and anxiety symptoms of family carers relatives with dementia at home over 2 years was cost-effective. Aims To assess the clinical effectiveness 6 impact on costs care admission. Method We conducted a randomised, parallel group, superiority trial recruiting from 4 November 2009 to 8 June 2011 6-year follow-up (trial registration: ISCTRN 70017938). A total 260 self-identified people were randomised 2:1 START, an...
OBJECTIVE One-third of cases focal epilepsy are drug refractory, and surgery might provide a cure. Seizure-free outcome after depends on the correct identification resection epileptogenic zone. In patients with no visible abnormality MRI, or in which presurgical evaluation yields discordant data, invasive stereoelectroencephalography (SEEG) recordings be necessary. SEEG is procedure multiple electrodes placed stereotactically key targets within brain to record interictal ictal...
Abstract Objective This study was undertaken to determine reasons for adults with drug‐resistant focal epilepsy who undergo presurgical evaluation not proceeding surgery, and identify predictors of this course. Methods We retrospectively analyzed data on 617 consecutive individuals evaluated surgery at a tertiary referral center between January 2015 December 2019. compared the characteristics those in whom decision proceed surgical treatment made underwent definitive same period....
There has been a significant rise in robotic trajectory guidance devices that have utilised for stereotactic neurosurgical procedures. These costs and associated learning curves. Previous studies reporting usage not undertaken prospective parallel-group comparisons before their introduction, so the comparative differences are unknown. We study difference stereoelectroencephalography electrode implantation time between device (iSYS1) manual frameless (PAD) patients with drug-refractory focal...
We aimed to estimate the clinical effectiveness of Community Occupational Therapy for people with dementia and family carers-UK version (Community in Dementia-UK [COTiD-UK]) relative treatment as usual (TAU). hypothesised that COTiD-UK would improve ability perform activities daily living (ADL), carers' sense competence, compared TAU.The study design was a multicentre, 2-arm, parallel-group, assessor-masked, individually randomised controlled trial (RCT) internal pilot. It conducted 15 sites...
A community-based occupational therapy intervention for people with mild to moderate dementia and their family carers (Community Occupational Therapy in Dementia (COTiD)) was found clinically cost effective the Netherlands but not Germany. This highlights need adapt implement complex interventions specific national contexts. The current trial aims evaluate United Kingdom-adapted living community (COTiD-UK) compared treatment as usual. study is a multi-centre, parallel-group, pragmatic...
The regression discontinuity (RD) design is a quasi-experimental that estimates the causal effects of treatment by exploiting naturally occurring rules. It can be applied in any context where particular or intervention administered according to pre-specified rule linked continuous variable. Such thresholds are common primary care drug prescription RD used estimate effect medication general population. results then contrasted those obtained from randomised controlled trials (RCTs) and inform...
Young adults living with perinatally acquired HIV (PAH) face many stressors. Sharing one's status may help coping these challenges but there are no rigorously evaluated interventions to support sharing in this population. The aim of study was explore the experiences participants a novel status-sharing intervention guided by motivational interviewing. We used cross-sectional, qualitative design. Ten young from Uganda (20-25 years; 6 female), nine UK (19-29 7 female) and five therapists (2 UK;...
This study aims to refine computer-assisted planning (CAP) of SEEG implantations by adding spatial constraints from prior trajectories ("Priors") improve safety and reduce manual adjustments, without increasing time. Retrospective validation based on 159 previously implanted (11 cases) planned the clinical standard CAP constrained with priors ("CAP + Priors"). Constraints included 31 target 51 entry zones, created 98 consecutive patients (763 trajectories). Each was two fellows, once Priors,...
The accurate and automatic localisation of SEEG electrodes is crucial for determining the location epileptic seizure onset. We propose an algorithm segmentation electrode bolts contacts that accounts bending in relation to regional brain anatomy.Co-registered post-implantation CT, pre-implantation MRI, parcellation images are used create regions interest automatically segment contacts. Contact search strategy based on direction bolt with distance angle constraints, addition post-processing...
ABSTRACT Background: People with Parkinson's disease (PD) who develop visuo‐perceptual deficits are at higher risk of dementia, but we lack tests that detect subtle and can be performed by untrained personnel. Hallucinations associated cognitive impairment typically involve perception complex objects. Changes in object may therefore a sensitive marker PD. Objective: We developed an online platform to test function. hypothesised (1) PD could detected using tests, (2) would preferentially...