A5044029740- Systemic Lupus Erythematosus Research
- Statistical Methods and Bayesian Inference
- Statistical Methods and Inference
- Advanced Causal Inference Techniques
- Graph theory and applications
- Atherosclerosis and Cardiovascular Diseases
- Peripheral Neuropathies and Disorders
- Dementia and Cognitive Impairment Research
- Advanced Graph Theory Research
- Multiple Sclerosis Research Studies
- Bayesian Methods and Mixture Models
- Graph Labeling and Dimension Problems
- Pulmonary Hypertension Research and Treatments
- Respiratory Support and Mechanisms
- Functional Brain Connectivity Studies
- Statistical Methods in Clinical Trials
- Systemic Sclerosis and Related Diseases
- Tensor decomposition and applications
- Recycling and utilization of industrial and municipal waste in materials production
- Rheumatoid Arthritis Research and Therapies
- Alzheimer's disease research and treatments
- Renal Diseases and Glomerulopathies
- Monoclonal and Polyclonal Antibodies Research
- Health Systems, Economic Evaluations, Quality of Life
- Gastric Cancer Management and Outcomes
MRC Biostatistics Unit
2016-2025
University of Cambridge
2016-2025
University of Sheffield
2022-2025
Affiliated Hospital of Youjiang Medical University for Nationalities
2025
North China Electric Power University
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
Guang’anmen Hospital
2025
Jiangxi Normal University
2012-2024
Insigneo
2024
Cambridge School
2024
Objective. To determine nephritis outcomes in a prospective multi-ethnic/racial SLE inception cohort. Methods. Patients the Systemic Lupus International Collaborating Clinics cohort (≤15 months of diagnosis) were assessed annually for estimated glomerular filtration rate (eGFR), proteinuria and end-stage renal disease (ESRD). Health-related quality life was measured by Short Form (36 questions) health survey questionnaire (SF-36) subscales, mental physical component summary scores. Results....
<h3>Background and aims</h3> We studied damage accrual factors determining development progression of in an international cohort systemic lupus erythematosus (SLE) patients. <h3>Methods</h3> The Systemic Lupus International Collaborating Clinics (SLICC) Inception Cohort recruited patients within 15 months developing four or more 1997 American College Rheumatology (ACR) criteria for SLE; the SLICC/ACR index (SDI) was measured annually. assessed relative rates transition using maximum...
Background— Chronic thromboembolic pulmonary hypertension results from incomplete resolution of emboli. Pulmonary endarterectomy (PEA) is potentially curative, but residual following surgery common and its impact on long-term outcome poorly understood. We wanted to identify factors correlated with poor after specifically define clinically relevant post-PEA. Methods Results— Eight hundred eighty consecutive patients (mean age, 57 years) underwent PEA for chronic hypertension. Patients...
Objectives To determine the frequency, accrual, attribution and outcome of neuropsychiatric (NP) events impact on quality life over 3 years in a large inception cohort patients with systemic lupus erythematosus (SLE). Methods The study was conducted by Systemic Lupus International Collaborating Clinics. Patients were enrolled within 15 months SLE diagnosis. NP identified using American College Rheumatology case definitions, decision rules derived to proportion disease attributable SLE....
The aim of this study was to describe the frequency, attribution, outcome and predictors seizures in systemic lupus erythematosus (SLE).The Systemic Lupus International Collaborating Clinics, or SLICC, performed a prospective inception cohort study. Demographic variables, global SLE disease activity (SLE Disease Activity Index 2000), cumulative organ damage (SLICC/American College Rheumatology Damage (SDI)) neuropsychiatric events were recorded at enrolment annually. anticoagulant,...
Objective Neuropsychiatric events occur unpredictably in systemic lupus erythematosus (SLE) and most biomarker associations remain to be prospectively validated. This study examined a disease inception cohort of 1047 SLE patients determine which autoantibodies at enrolment predicted subsequent neuropsychiatric events. Methods Patients with recent diagnosis were assessed for up 10 years using the American College Rheumatology case definitions. Decision rules graded stringency determined...
Objective To examine the frequency, characteristics, and outcome of mood disorders, as well clinical autoantibody associations, in a multiethnic/racial, prospective inception cohort patients with systemic lupus erythematosus (SLE). Methods Patients were assessed annually for disorders (4 types, according to Diagnostic Statistical Manual Mental Disorders, Fourth Edition) 18 other neuropsychiatric events. Global disease activity scores (SLE Disease Activity Index 2000 [SLEDAI‐2K]), damage...
Objective. The aim of this study was to describe the outcomes and predictors for development damage in a large inception cohort SLE patients. Methods. This prospective longitudinal patients were included if they recruited within 3 years achieving fourth ACR criterion SLE. Data collected on disease activity, treatment. Information death provided by Office National Statistics. censoring date analysis 31 December 2010. A standardized mortality ratio calculated. Poisson regression used determine...
Statistical models that involve a two-part mixture distribution are applicable in variety of situations. Frequently, the two parts model for binary response variable and outcome is conditioned on response. Two common examples zero-inflated or hurdle count data semicontinuous data. Recently, there has been particular interest use these analysis repeated measures an over time. The aim this review to consider motivations such context highlight central issues arise with their use. We examine...
To determine, in a large, multiethnic/multiracial, prospective inception cohort of patients with systemic lupus erythematosus (SLE), the frequency, attribution, clinical, and autoantibody associations psychosis short- long-term outcomes as assessed by physicians patients.Patients were evaluated annually for 19 neuropsychiatric (NP) events including psychosis. Scores on Systemic Lupus Erythematosus Disease Activity Index 2000, International Collaborating Clinics/American College Rheumatology...
Abstract Objective To determine the short‐term outcome of neuropsychiatric (NP) events upon enrollment into an international inception cohort patients with systemic lupus erythematosus (SLE). Methods The study was performed by Systemic Lupus International Collaborating Clinics. Patients were enrolled within 15 months SLE diagnosis and NP characterized using American College Rheumatology case definitions. Decision rules derived to identify attributable SLE. Physician scores patient‐derived...
Semicontinuous data in the form of a mixture zeros and continuously distributed positive values frequently arise biomedical research. Two-part mixed models with correlated random effects are an attractive approach to characterize complex structure longitudinal semicontinuous data. In practice, however, independence assumption about these may often be made for convenience computational feasibility. this article, we show that bias can induced regression coefficients when truly but misspecified...
Objective. To prospectively examine neuropsychiatric (NP) events and their association with health related quality of life (HRQOL) over time in patients systemic lupus erythematosus (SLE). Methods. In an observational cohort study from a single academic center, NP attribution were identified at enrollment annual assessments for up to 7 years. characterized using the American College Rheumatology case definitions; other variables global SLE disease activity cumulative organ damage. The...
To determine the frequency, characteristics, and outcomes of cerebrovascular events (CerVEs), as well clinical autoantibody associations in a multiethnic/racial inception cohort patients with systemic lupus erythematosus (SLE).A total 1,826 were assessed annually for 19 neuropsychiatric (NP) events, including 5 types CerVEs: 1) stroke, 2) transient ischemia, 3) chronic multifocal 4) subarachnoid/intracranial hemorrhage, 5) sinus thrombosis. Global disease activity (Systemic Lupus...
Objective To determine the frequency, clinical characteristics, associations, and outcomes of different types peripheral nervous system (PNS) disease in a multiethnic/multiracial, prospective inception cohort systemic lupus erythematosus (SLE) patients. Methods Patients were evaluated annually for 19 neuropsychiatric (NP) events including 7 PNS disease. SLE activity, organ damage, autoantibodies, patient physician assessment outcome measured. Time to event linear regressions used as...
PREVENT is a multi-centre prospective cohort study in the UK and Ireland that aims to examine midlife risk factors for dementia identify describe earliest indices of disease development. The programme one original epidemiological initiatives targeting as critical window intervention neurodegenerative conditions. This paper provides an overview protocol presents first summary results from initial baseline data cohort. Participants provide demographic data, biological samples (blood, saliva,...
Computerized neuropsychological testing may facilitate screening for cognitive impairment in systemic lupus erythematosus (SLE). This study was undertaken to compare patients with SLE, rheumatoid arthritis (RA), and multiple sclerosis (MS) healthy controls using the Automated Neuropsychological Assessment Metrics (ANAM).Patients SLE (n = 68), RA 33), MS 20) were compared 29). Efficiency of performance on 8 ANAM subtests examined throughput (TP), inverse efficiency (IE), adjusted IE scores....
Objective. We examined the association between responses on a screening questionnaire and objective performance computer-administered test of cognitive abilities in systemic lupus erythematosus (SLE). Methods. The Cognitive Symptom Inventory (CSI) Hospital Anxiety Depression Scales (HADS) questionnaires were compared patients with SLE or rheumatoid arthritis (RA). Automated Neuropsychological Assessment Metrics (ANAM) was used to evaluate SLE. Efficiency measured by “throughput” (number...
Abstract Down syndrome is the most common human chromosomal disorder. Whether a risk factor for severe COVID-19 outcomes in pediatric patients remains unclear, especially low-to-middle income countries. We gathered data on <18 years of age with SARS-CoV-2 infection from national registry Brazil to assess among syndrome. included 14,684 hospitalized patients, 261 whom had After adjustments sociodemographic and medical factors, 1.8 times higher odds dying (odds ratio 1.82, 95% CI 1.22–2.68)...
To study bidirectional change and predictors of in estimated glomerular filtration rate (GFR) proteinuria lupus nephritis (LN) using a multistate modeling approach.Patients the Systemic Lupus International Collaborating Clinics inception cohort were classified annually into GFR state 1 (>60 ml/minute), 2 (30-60 or 3 (<30 ml/minute) (<0.25 gm/day), (0.25-3.0 (>3.0 end-stage renal disease (ESRD) death. Using modeling, relative transition rates between states indicated improvement...
Weighting methods offer an approach to estimating causal treatment effects in observational studies. However, if weights are estimated by maximum likelihood, misspecification of the assignment model can lead weighted estimators with substantial bias and variance. In this paper, we propose a unified framework for constructing such that set measured pretreatment covariates is unassociated after weighting. We derive conditions weight estimation eliminating associations between these...
Chronic thromboembolic pulmonary hypertension (CTEPH) is an important consequence of embolism that associated with abnormalities in haemostasis. We investigated the ADAMTS13-von Willebrand factor (VWF) axis CTEPH, including its relationship disease severity, inflammation, ABO groups and ADAMTS13 genetic variants.ADAMTS13 VWF plasma antigen levels were measured patients CTEPH (n=208), chronic without (CTED) (n=35), resolved (n=28), idiopathic arterial (n=30) healthy controls (n=68)....