A5015850975- Sinusitis and nasal conditions
- Allergic Rhinitis and Sensitization
- Olfactory and Sensory Function Studies
- Nasal Surgery and Airway Studies
- Advanced Chemical Sensor Technologies
- Obstructive Sleep Apnea Research
- Asthma and respiratory diseases
- Biochemical Analysis and Sensing Techniques
- Head and Neck Cancer Studies
- Head and Neck Surgical Oncology
- Peptidase Inhibition and Analysis
- Mechanisms of cancer metastasis
- Essential Oils and Antimicrobial Activity
- Otolaryngology and Infectious Diseases
- Cancer-related gene regulation
- Salivary Gland Tumors Diagnosis and Treatment
- Long-Term Effects of COVID-19
- Infectious Diseases and Tuberculosis
- Tracheal and airway disorders
- Voice and Speech Disorders
- Indoor Air Quality and Microbial Exposure
- Respiratory and Cough-Related Research
- Streptococcal Infections and Treatments
- Cancer-related molecular mechanisms research
- Cell Adhesion Molecules Research
University of Padua
2016-2025
Humanitas University
2023
University of Pisa
2021
Creative Research Enterprises (United States)
2021
Center for Neurosciences
2013
Background: Olfactory dysfunction is an increasingly recognised condition, associated with reduced quality of life and major health outcomes such as neurodegeneration death.However, translational research in this field limited by heterogeneity methodological approach, including definitions impairment, improvement appropriate assessment techniques.Accordingly, effective treatments for smell loss are limited.In effort to encourage high comparable work field, among others, we propose the...
Chronic rhinosinusitis with nasal polyps (CRSwNP) is associated significant morbidity and reduced health-related quality of life. Findings from clinical trials have demonstrated the effectiveness dupilumab in CRSwNP, although real-world evidence still limited.This Phase IV real-life, observational, multicenter study assessed safety patients severe uncontrolled CRSwNP (n = 648) over first year treatment. We collected data at baseline after 1, 3, 6, 9, 12 months follow-up. focused on score...
Background: Since publication of the original Position Paper on Olfactory Dysfunction in 2017 (PPOD-17), personal and so- cietal burden olfactory disorders has come sharply into focus through lens COVID-19 pandemic. Clinicians, scientists public are now more aware importance olfaction, impact its dysfunction quality life, nutrition, social relationships mental health. Accordingly, new basic, translational clinical research resulted significant pro- gress since PPOD-17. In this updated...
Background: Chronic rhinosinusitis with nasal polyps (CRSwNP) represents 25−30% of all CRS cases, and in the most severe forms it is associated a poor quality life high rate polyps’ recurrence after surgery. Dupilumab has been suggested as treatment option for CRSwNP. Methods: Patients CRSwNP receiving dupilumab from January 2021 were followed up at 1, 3, 6, 9 12 months first administration considered this study. At baseline each follow-up, patients underwent endoscopy completed Sinonasal...
Background: Local and systemic corticosteroids have long been the workhorse in management of chronic rhinosinusitis with nasal polyps (CRSwNP), although there is no universally accepted modality prescription. We carried out a survey Italy to capture current trends use topical patients CRSwNP. Methods: A was set up on Survey Monkey®. Each author distributed link an ad hoc manner total 437 participants filled survey. Results: Mometasone furoate (79.3%) most frequently prescribed, administered...
Introduction The impairment of the sense smell is often related to chronic rhinosinusitis (CRS) with or without nasal polyps (CRSwNP, CRSsNP). CRSwNP a frequent condition that drastically worsens quality life those affected; it has higher prevalence than CRSsNP. patients experience severe loss earlier presentation and are more likely recurrence their symptoms, requiring revision surgery. Methods present study performed multicentric data collection, enrolling 811 CRS divided according...
Introduction Dupilumab, a monoclonal antibody targeting the IL-4 receptor alpha subunit, effectively blocks both and IL-13 mediated pathways. Its introduction has represented significant advancement in treatment of severe asthma other Type 2 (T2) conditions, including nasal polyps, atopic dermatitis, eosinophilic esophagitis. To date, Dupilumab demonstrated optimal efficacy safety profile.
Chronic rhinosinusitis with nasal polyps (CRSwNP) in the most severe forms is associated a poor quality of life. Dupilumab has been suggested as an add-on treatment option for CRSwNP. Severe CRSwNP patients treated dupilumab different rhinological units were followed up at 1, 3, 6 and 12 months from first administration considered this study. At baseline (T0) each follow-up, underwent endoscopy completed sinonasal outcome test (SNOT)-22, visual analogue scale (VAS) smell/nasal obstruction,...
Adherence to treatment is essential in chronic rhinosinusitis with nasal polyposis (CRSwNP). Intranasal corticosteroids (INCS) are the first-line therapy, followed by systemic and surgery if needed. In cases of refractory disease, biologics added conventional treatment, making adherence INCS crucial assessing eligibility for these targeted therapies. The purpose this review examine assessment rate, before starting during biologic therapy. We conducted a comprehensive literature focusing on...
Aims: Peak Nasal Inspiratory Flow (PNIF) is an easy method to assess nasal patency. Normative unilateral PNIF data in adults have been proposed. The study purpose was compare and values total resistances measured by anterior active rhinomanometry (AAR) subjects with without obstruction see whether PNIFis sensitive detect obstruction. Methods results: Measurements of PNIF, AAR were performed 125 volunteers. Seventy them healthy not complaining symptoms entered into the as the'normal' group....
Since December 2019, a novel coronavirus SARS-CoV-2 (Covid-19) outbreak emerged in China and spread rapidly several countries. As of April 5, 2020, 1.218.474 cases were confirmed with 65.884 deaths worldwide (1). The clinical manifestations Covid-19 range from asymptomatic carrier status to severe pneumonia. In study 7,736 patients China, all the symptoms, hyposmia was not reported any patient(2). Anyway, it is now clear that olfactory dysfunction may also be present these patients(3) as...
Nasal obstruction is the most common symptom in nasal diseases. It can be evaluated objectively, that by means of peak inspiratory flow (PNIF) measures and/or subjectively validated questionnaires. However, it has been reported there a lack reliable correlation between subjective and objective measurements obstruction. The aim present study was to evaluate PNIF sensation measured visual analogue scale (VAS) large population consecutive rhinologic patients.Prospective clinical study.Tertiary...
Abstract Objectives To determine the prevalence of olfactory and taste dysfunction (OD; TD) among COVID‐19 positive health care workers (HCWs), their associated risk factors prognosis. Methods Between May June 2020, a longitudinal multicenter study was conducted on symptomatic PCR confirmed HCWs (COVID‐19 positive) in London Padua. Results Hundred fourteen were surveyed with response rate 70.6% over median follow‐up period 52 days. UK OD TD 73.1% 69.2%, respectively. There male to female...
The relationship between olfactory function, rhinencephalon and forebrain changes in Kallmann syndrome (KS) have not been adequately investigated. We evaluated a large cohort of male KS patients using Sniffin' Sticks MRI order to study bulb (OB) volume, sulcus (OS) depth, cortical thickness close the OS, phenotype.Olfaction was assessed administering Sticks®, 38 17 controls (by means Screening 12 test®). All subjects underwent magnetic resonance imaging (MRI) OB thickness.Compared controls,...