A5021652187- Olfactory and Sensory Function Studies
- Advanced Chemical Sensor Technologies
- Biochemical Analysis and Sensing Techniques
- Allergic Rhinitis and Sensitization
- Sinusitis and nasal conditions
- Asymmetric Synthesis and Catalysis
- Nasal Surgery and Airway Studies
- Long-Term Effects of COVID-19
- Chemical synthesis and alkaloids
- Neurobiology and Insect Physiology Research
- Asthma and respiratory diseases
- EEG and Brain-Computer Interfaces
- Delphi Technique in Research
- Facial Nerve Paralysis Treatment and Research
- Obstructive Sleep Apnea Research
- Antifungal resistance and susceptibility
- Bone Tumor Diagnosis and Treatments
- Healthcare Systems and Practices
- Insect Pheromone Research and Control
- Ocular Infections and Treatments
- Vagus Nerve Stimulation Research
- Ocular Diseases and Behçet’s Syndrome
- Axial and Atropisomeric Chirality Synthesis
- Enhanced Recovery After Surgery
- Diabetes Management and Education
Cliniques Universitaires Saint-Luc
2015-2025
UCLouvain
2013-2025
University of Southern Denmark
2022
Université Libre de Bruxelles
2020
Macquarie University
2019
Centre Hospitalier Universitaire Amiens-Picardie
2013-2014
Ninewells Hospital
2011
University of Dundee
2011
Ghent University Hospital
2011
Abstract Recent anecdotal and scientific reports have provided evidence of a link between COVID-19 chemosensory impairments, such as anosmia. However, these downplayed or failed to distinguish potential effects on taste, ignored chemesthesis, generally lacked quantitative measurements. Here, we report the development, implementation, initial results multilingual, international questionnaire assess self-reported quantity quality perception in 3 distinct modalities (smell, chemesthesis) before...
Abstract In a preregistered, cross-sectional study, we investigated whether olfactory loss is reliable predictor of COVID-19 using crowdsourced questionnaire in 23 languages to assess symptoms individuals self-reporting recent respiratory illness. We quantified changes chemosensory abilities during the course illness 0–100 visual analog scales (VAS) for participants reporting positive (C19+; n = 4148) or negative (C19−; 546) laboratory test outcome. Logistic regression models identified...
With the COVID-19 pandemic, chemosensory dysfunction are among most prevalent symptoms. Most reports subjective evaluations, which have been suggested to be unreliable. The objective is test and recovery based on extensive psychophysical tests in during course of disease.Prospective cohort study.A total 111 patients from four centers participated study. All tested positive for SARS-COV-2 with RT-PCR. They were within 3 days diagnosis 28 169 after infection. Testing included olfactory testing...
Background: Since publication of the original Position Paper on Olfactory Dysfunction in 2017 (PPOD-17), personal and so- cietal burden olfactory disorders has come sharply into focus through lens COVID-19 pandemic. Clinicians, scientists public are now more aware importance olfaction, impact its dysfunction quality life, nutrition, social relationships mental health. Accordingly, new basic, translational clinical research resulted significant pro- gress since PPOD-17. In this updated...
Anosmia constitutes a prominent symptom of COVID-19. However, anosmia is also common acute colds various origins. In contrast to an cold, it appears from several questionnaire-based studies that in the context COVID-19 infection, main rhinological and usually not associated with other symptoms such as rhinorrhoea or nasal obstruction. Until now, no study has directly compared smell taste function between patients causes upper respiratory tract infection (URTI) using valid reliable...
Several prognostic factors influencing the recovery from olfactory dysfunction have been described. The aim of this study was to investigate whether bulb volume could be used as a new predictor in postinfectious and posttraumatic loss.Cohort study; Level evidence, 4. Setting Tertiary university clinic, department otolaryngology.A cohort 60 patients with (n = 28) loss 32) investigated. Assessment function performed using orthonasal (Sniffin' Sticks test) retronasal psychophysical tests, at...
The frequent association between coronavirus disease 2019 (COVID-19) and olfactory dysfunction is creating an unprecedented demand for a treatment of the loss. Systemic corticosteroids have been considered as therapeutic option. However, based on current literature, we call caution using these treatments in early COVID-19-related because: (1) evidence supporting their usefulness weak; (2) rate spontaneous recovery high; (3) well-known potential adverse effects. We encourage randomized...
It has been shown that the volume of olfactory bulb (OB) changes with function. The aim this study was to investigate whether OB and function in early blind (EB) subjects increase compared controls. Psychophysical testing performances volumetric measurements assessed by an MRI scan were studied. Quantitative expressed odor discrimination odor-free identification scores higher EB mean right, left total 65.40, 75.48, 140.89 mm, respectively for 54.47, 52.11, 106.60 controls, these differences...
<h3>BACKGROUND AND PURPOSE:</h3> In congenital anosmia, the OB and OT can be aplastic or hypoplastic. clinical routine, these are sometimes difficult to assess. We thus wanted investigate morphologic differences of OS in patients with IA since birth early childhood comparison controls, whether there is a depth that predictive IA. <h3>MATERIALS METHODS:</h3> Within context 2-center study, we investigated 36 70 controls. MR imaging was performed standard quadrature head coil (1.5T; T1-...
The recording of olfactory and trigeminal chemosensory event-related potentials (ERPs) has been proposed as an objective non-invasive technique to study the cortical processing odors in humans. Until now, responses have characterized mainly using across-trial averaging time domain. Unfortunately, ERPs, particular, exhibit a relatively low signal-to-noise ratio. Hence, although is increasingly used basic research well clinical practice evaluate people suffering from disorders, its current...
The presence of cerebral lesions in patients with neurosensory alterations provides a unique window into brain function. Using fuzzy logic based combination morphological information about 27 olfactory-eloquent regions acquired four different imaging techniques, patterns damage were analyzed 127 who displayed anosmia, i.e., complete loss the sense smell (n = 81), or other and mechanistically still incompletely understood olfactory dysfunctions including parosmia, distorted perceptions...
Background Olfactory dysfunction is deemed to be a significant contributor poor quality of life in chronic rhinosinusitis (CRS). Objective To assess and compare the effectiveness three modalities corticosteroids administration patients with CRS. Study Design A prospective randomized controlled study Methods Thirty CRS were groups depending on route administration: 16 days by oral (Medrol (Pfizer, Belgique), 32 mg/8 −16 mg/4 days–8 days); nasal spray (Rhinocort (AstraZeneca, 2 × 64...
The current COVID-19 or Sars-CoV-2 pandemic increased awareness of hyposmia anosmia, as this can be an accompanying symptom.In mild cases, anosmia without rhinorrhea the only presenting symptom infection.Timely identification lead to early detection otherwise asymptomatic carriers.History taking and essential clinical assessment with appropriate protective measures performed in patients whom is suspected.Patients nasal obstruction should considered suspect initiate testing self-isolation.As...
Olfactory impairment is a recognized early indicator of neurodegenerative diseases (NDs), such as Alzheimer's disease (AD). Intracellular aggregates hyperphosphorylated tau protein, referred to neurofibrillary tangles (NFTs), are hallmark AD. NFTs found in the olfactory bulb (OB) and entorhinal cortex (EC), both crucial for processing information. We explored hypothesis that typical lesions could appear progress along regions reach connected areas critically affected AD (e.g. EC hippocampal...