A5055093593- Biochemical Analysis and Sensing Techniques
- Olfactory and Sensory Function Studies
- Advanced Chemical Sensor Technologies
- Prenatal Substance Exposure Effects
- Diet and metabolism studies
- Eating Disorders and Behaviors
- Bariatric Surgery and Outcomes
- Alcohol Consumption and Health Effects
- Regulation of Appetite and Obesity
- Neuroscience of respiration and sleep
- Fatty Acid Research and Health
- Neuroendocrine regulation and behavior
- Breastfeeding Practices and Influences
- Culinary Culture and Tourism
- Head and Neck Cancer Studies
- Obesity and Health Practices
- Alcoholism and Thiamine Deficiency
- Sensory Analysis and Statistical Methods
- Birth, Development, and Health
- Endoplasmic Reticulum Stress and Disease
- Multisensory perception and integration
- RNA regulation and disease
- Infant Health and Development
- Nutrition and Health in Aging
- Diet, Metabolism, and Disease
University of Illinois Urbana-Champaign
2017-2025
Illinois College
2023-2025
Urbana University
2021
Goodwin College
2019
Atkins (United States)
2014-2016
Washington University in St. Louis
2010-2016
Center for Human Genetics
2014
Monell Chemical Senses Center
2003-2010
Instituto de Investigación Médica Mercedes y Martín Ferreyra
1998-2006
Consejo Nacional de Investigaciones Científicas y Técnicas
2000-2004
Objective. Flavor is the primary dimension by which young children determine food acceptance. However, are not merely miniature adults because sensory systems mature postnatally and their responses to certain tastes differ markedly from adults. Among these differences heightened preferences for sweet-tasting greater rejection of bitter-tasting foods. The present study tests hypothesis that genetic variations in newly discovered TAS2R38 taste gene as well cultural associated with sensitivity...
Abstract Recent anecdotal and scientific reports have provided evidence of a link between COVID-19 chemosensory impairments, such as anosmia. However, these downplayed or failed to distinguish potential effects on taste, ignored chemesthesis, generally lacked quantitative measurements. Here, we report the development, implementation, initial results multilingual, international questionnaire assess self-reported quantity quality perception in 3 distinct modalities (smell, chemesthesis) before...
The precise orosensory inputs engaged for dietary lipids detection in humans are unknown. We evaluated whether a common single nucleotide polymorphism (rs1761667) the CD36 gene that reduces expression and addition of orlistat, lipase inhibitor, to reduce FA release from triacylglycerols (TGs), main component fats, would attenuate fat sensitivity humans. Twenty-one obese subjects with different rs1761667 genotypes (6 AA, 7 AG, 8 GG) were studied on two occasions which oleic acid triolein...
OBJECTIVE Nonnutritive sweeteners (NNS), such as sucralose, have been reported to metabolic effects in animal models. However, the relevance of these findings human subjects is not clear. We evaluated acute sucralose ingestion on response an oral glucose load obese subjects. RESEARCH DESIGN AND METHODS Seventeen (BMI 42.3 ± 1.6 kg/m2) who did use NNS and were insulin sensitive (based a homeostasis model assessment resistance score ≤2.6) underwent 5-h modified tolerance test two separate...
Abstract In a preregistered, cross-sectional study, we investigated whether olfactory loss is reliable predictor of COVID-19 using crowdsourced questionnaire in 23 languages to assess symptoms individuals self-reporting recent respiratory illness. We quantified changes chemosensory abilities during the course illness 0–100 visual analog scales (VAS) for participants reporting positive (C19+; n = 4148) or negative (C19−; 546) laboratory test outcome. Logistic regression models identified...
The goal of this study was to determine whether obese women exhibit altered umami and sweet taste perception compared normal-weight women. A total 57 subjects (23 34 normal weight) participated in a 2-day separated by 1 week. Half the each group were evaluated using monosodium glutamate (MSG; prototypical stimulus) on first test day sucrose second day; order reversed for remaining We used two-alternative forced-choice staircase procedures measure detection thresholds, tracking technique...
Abstract Background The purpose of this study was to investigate the effect TAS2R38 haplotypes and age on human bitter taste perception. Results Children (3 10 yrs), adolescents (11 19 yrs) adults (mostly mothers, 20 55 yrs (N = 980) were measured for thresholds 6-n-propylthiouracil (PROP) genotyped three polymorphisms AS2R38 gene (A49P, V262A, I296V). Subjects grouped by haplotype age, as well sex race/ethnicity, compared PROP thresholds. with same similar in threshold regardless...
Roux-en-Y gastric bypass (RYGB) surgery causes greater weight loss than laparoscopic adjustable banding (LAGB). We tested the hypothesis that RYGB has loss-independent effects on taste perception, which influence eating behavior and contribute to loss.Subjects were studied before after ∼20% induced by (n = 17) or LAGB 10). The following have been evaluated: sensitivity for sweet, salty savory stimuli, sucrose monosodium glutamate (MSG) preferences, sweetness palatability, behavior,...
Objective To test the hypotheses that bariatric surgery‐induced weight loss: induces remission of food addiction (FA), and normalizes other eating behaviors associated with FA. Methods Forty‐four obese subjects (BMI= 48 ± 8 kg/m 2 ) were studied before after ∼20% loss induced by surgery (25 Roux‐en‐Y gastric bypass, 11 laparoscopic adjustable banding, eight sleeve gastrectomy). We assessed: FA (Yale Food Addiction Scale), cravings (Food Craving Inventory), restrictive, emotional external...
Millions of people in the United States experience a reduced or distorted ability to smell taste. Chemosensory disorders such as anosmia (the inability smell), parosmia (distorted dysgeusia (altered taste) have major impacts on health and quality life including difficulty sensing dangers fire spoilage, diminished palatability food drink that can negatively influence diet nutrition, feelings social isolation, an increased incidence frailty, anxiety, depression. Smell taste dysfunction also be...
Background: Despite popular beliefs that smoking affects the sensitivity and liking of sweet‐tasting foods beverages, few psychophysical studies have examined this phenomenon none taken into account individual’s family history alcoholism (FH+), a predictor heightened sweet preferences. Methods: A within‐ between‐subjects study was conducted to determine effect both cigarette an acute exposure nicotine on taste preferences in women. Two groups were studied 2 days separated by 1 week: women...
Demographics and anthropometry Black mothers were significantly younger (33.6 ± 0.8 versus 38.4 0.7 years) more likely to be single (71% 2%), with lower household incomes fewer years of education (13.4 0.2 14.8 0.3 when compared White (all Ps < 0.001). There significant effects race/ethnicity on children’s age (P 0.025); children older (8.1 than (7.4 0.1 years). No statistical differences observed between the two groups in BMI categories, however. Despite various demographic racial/ethnic...
The present study tested the hypothesis that efficacy of sucrose in reducing pain during Cold Pressor Test (CPT) was related to its hedonic value. To this aim, we determined most preferred level and analgesic properties 24% w/v CPT 242, 5- 10-year-old children their mothers. Outcome measures included thresholds (the time at which discomfort first indicated) tolerance length hand kept cold water bath). Although children, as a group, significantly higher concentrations than adults, there were...
The goal of this study was to test the hypothesis that weight loss induced by Roux-en-Y gastric bypass (RYGB) has greater effects on taste perception and eating behavior than comparable sleeve gastrectomy (SG). We evaluated following outcomes in 31 subjects both before after ~20% RYGB (n = 23) or SG 8): (1) sweet, savory, salty sensitivity; (2) most preferred concentrations sucrose monosodium glutamate; (3) sweetness palatability, using validated sensory testing techniques; (4) behavior,...
Despite the lack of scientific evidence to support claim that alcohol is a galactagogue, lactating women have been advised drink as an aid lactation for centuries. To test hypothesis consumption affects hormonal response in women, we conducted within-subjects design study which 17 consumed 0.4 g/kg dose orange juice during one session and equal volume other. Changes plasma prolactin, oxytocin, cortisol levels after breast stimulation, lactational performance, mood states were compared under...
To determine whether depression and family history of alcoholism are associated with heightened sweet preferences in children, before they have experienced alcohol or tobacco at a time during the life-span when sweets particularly salient. Design Between- within-subject experimental study.Children, 5-12 years old (n = 300), formed four groups based on dependence up to second-degree relatives [positive (FHP) versus negative (FHN)] depressive symptoms as determined by Pictorial Depression...
To address gaps in knowledge, our objectives were to (1) determine whether there are age-related changes sweet taste detection thresholds, as has been observed for preferences, and (2) thresholds preferences significantly related each other from childhood adulthood. We combined data studies that used the same validated psychophysical techniques measure sucrose threshold most preferred concentration children (n = 108), adolescents 172), adults 205). There significant effects of age group on...