A5046474433- Bioinformatics and Genomic Networks
- Olfactory and Sensory Function Studies
- Advanced Chemical Sensor Technologies
- Gene Regulatory Network Analysis
- Gene expression and cancer classification
- Bacterial Genetics and Biotechnology
- Biochemical Analysis and Sensing Techniques
- Computational Drug Discovery Methods
- Machine Learning in Healthcare
- Molecular Biology Techniques and Applications
- Viral Infectious Diseases and Gene Expression in Insects
- Artificial Intelligence in Healthcare
- Cell Image Analysis Techniques
- Circadian rhythm and melatonin
- Photosynthetic Processes and Mechanisms
- Scientific Computing and Data Management
- Microbial Metabolic Engineering and Bioproduction
- Genomics and Phylogenetic Studies
- Genetics, Bioinformatics, and Biomedical Research
- Artificial Intelligence in Healthcare and Education
- Neurobiology and Insect Physiology Research
- RNA and protein synthesis mechanisms
- Genomics and Chromatin Dynamics
- Metabolomics and Mass Spectrometry Studies
- Bacteriophages and microbial interactions
IBM (United States)
2015-2024
IBM Research - Thomas J. Watson Research Center
2013-2023
Universidade Federal de Minas Gerais
2015-2021
Icahn School of Medicine at Mount Sinai
2017-2020
University of Toronto
2015
Philip Morris International (Switzerland)
2015
Clemson University
2014
Hunan Agricultural University
2014
University of California, Santa Barbara
2014
Wayne State University
2013-2014
Abstract Recent anecdotal and scientific reports have provided evidence of a link between COVID-19 chemosensory impairments, such as anosmia. However, these downplayed or failed to distinguish potential effects on taste, ignored chemesthesis, generally lacked quantitative measurements. Here, we report the development, implementation, initial results multilingual, international questionnaire assess self-reported quantity quality perception in 3 distinct modalities (smell, chemesthesis) before...
We have generated several stable cell lines expressing GFP-labeled centrin. This fusion protein becomes concentrated in the lumen of both centrioles, making them clearly visible living cell. Time-lapse fluorescence microscopy reveals that centriole pair inherited after mitosis splits during or just telophase. At this time mother remains near center while daughter migrates extensively throughout cytoplasm. differential behavior is not related to presence a nucleus because it also observed...
How will this molecule smell? We still do not understand what a given substance smell like. Keller et al. launched an international crowd-sourced competition in which many teams tried to solve how the of be perceived by humans. The were access database responses from subjects who had sniffed large number molecules and been asked rate each across range different qualities. also comprehensive list physical chemical features smelled. produced algorithms predict correspondence between quality...
Abstract In a preregistered, cross-sectional study, we investigated whether olfactory loss is reliable predictor of COVID-19 using crowdsourced questionnaire in 23 languages to assess symptoms individuals self-reporting recent respiratory illness. We quantified changes chemosensory abilities during the course illness 0–100 visual analog scales (VAS) for participants reporting positive (C19+; n = 4148) or negative (C19−; 546) laboratory test outcome. Logistic regression models identified...
In contrast to current models, fluorescence resonance energy transfer measurements using a single-cell imaging assay with fluorescent forms of PER and TIM showed that these proteins bind rapidly persist in the cytoplasm while gradually accumulating discrete foci. After approximately 6 hours, complexes abruptly dissociated, as independently moved nucleus narrow time frame. The per(L) mutation delayed nuclear accumulation vivo our cultured cell system, but without affecting rates PER/TIM...
Abstract Ontogenetic shifts in plants are ubiquitous, but their ecological and evolutionary significance remain largely unknown. Juveniles have few opportunities to accumulate sufficient biomass withstand damage, whereas adults allocate resources reproduction. Thus, age‐specific environmental filters expected drive selection towards specific resource‐investment strategies for each developmental stage. We tested whether species exhibited that favour faster rates of accumulation during early...
Abstract Motivation: After more than a decade since microarrays were used to predict phenotype of biological samples, real-life applications for disease screening and identification patients who would best benefit from treatment are still emerging. The interest the scientific community in identifying approaches develop such prediction models was reaffirmed competition style international collaboration called IMPROVER Diagnostic Signature Challenge whose results we describe herein. Results:...
Whole-cell models that explicitly represent all cellular components at the molecular level have potential to predict phenotype from genotype. However, even for simple bacteria, whole-cell will contain thousands of parameters, many which are poorly characterized or unknown. New algorithms needed estimate these parameters and enable researchers build increasingly comprehensive models. We organized Dialogue Reverse Engineering Assessments Methods (DREAM) 8 Whole-Cell Parameter Estimation...
Accurate estimation of parameters biochemical models is required to characterize the dynamics molecular processes. This problem intimately linked identifying most informative experiments for accomplishing such tasks. While significant progress has been made, effective experimental strategies parameter identification and distinguishing among alternative network topologies remain unclear. We approached these questions in an unbiased manner using a unique community-based approach context DREAM...
Motivation: Inferring how humans respond to external cues such as drugs, chemicals, viruses or hormones is an essential question in biomedicine. Very often, however, this cannot be addressed because it not possible perform experiments humans. A reasonable alternative consists of generating responses animal models and ‘translating’ those results The limitations translation, are far from clear, systematic assessments its actual potential urgently needed. sbv IMPROVER (systems biology...
The recent advent of CRISPR and other molecular tools enabled the reconstruction cell lineages based on induced DNA mutations promises to solve ones more complex organisms. To date, no lineage algorithms have been rigorously examined for their performance robustness across dataset types number cells. benchmark such methods, we decided organize a DREAM challenge using in vitro experimental intMEMOIR recordings silico data C. elegans tree about 1,000 cells Mus musculus 10,000 Some 22...
During Bacillus subtilis sporulation, an endocytic-like process called engulfment results in one cell being entirely encased the cytoplasm of another cell. The driving force underlying this membrane movement has remained unclear, although components machinery have been characterized. Here we provide evidence that synthesis peptidoglycan, rigid, strength bearing extracellular polymer bacteria, is a key part missing force-generating mechanism for engulfment. We observed sites peptidoglycan...
The biological responses to external cues such as drugs, chemicals, viruses and hormones, is an essential question in biomedicine the field of toxicology, cannot be easily studied humans. Thus, biomedical research has continuously relied on animal models for studying impact these compounds attempted 'translate' results In this context, SBV IMPROVER (Systems Biology Verification Industrial Methodology PROcess VErification Research) collaborative initiative, which uses crowd-sourcing...
Abstract There has been recent progress in predicting whether common verbal descriptors such as “fishy”, “floral” or “fruity” apply to the smell of odorous molecules. However, accurate predictions have achieved only for a small number descriptors. Here, we show that applying natural-language semantic representations on set general olfactory perceptual allows inference ratings mono-molecular odorants over large and potentially arbitrary This is noteworthy given prevailing view humans’...
Individual cells in clonal populations often respond differently to environmental changes; for binary phenotypes, such as cell death, this can be measured a fractional response. These types of responses have been attributed cell-intrinsic stochastic processes and variable abundances biochemical constituents, proteins, but the influence organelles is still under investigation. We use response TNF-related apoptosis inducing ligand (TRAIL) new statistical framework determining parameter on...
The recently discovered bactericidal properties of nanostructures on wings insects such as cicadas and dragonflies have inspired the development similar nanostructured surfaces for antibacterial applications. Since most applications require covering a considerable amount area, practical fabrication method needs to be cost-effective scalable. However, reported nanofabrication methods either expensive equipment or high temperature process, limiting cost efficiency scalability. Here, we report...