A5071064116- Sarcoma Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Genetics and Neurodevelopmental Disorders
- Neuroendocrine Tumor Research Advances
- Pancreatic and Hepatic Oncology Research
- Pancreatic function and diabetes
- Adrenal and Paraganglionic Tumors
- Neuroblastoma Research and Treatments
- Lung Cancer Research Studies
- Bone Tumor Diagnosis and Treatments
- Hormonal Regulation and Hypertension
- Cardiac tumors and thrombi
- Vascular Tumors and Angiosarcomas
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- Adrenal Hormones and Disorders
- Cancer Cells and Metastasis
- Genetic factors in colorectal cancer
- CAR-T cell therapy research
- Digestive system and related health
- Cytokine Signaling Pathways and Interactions
- Soft tissue tumor case studies
- Radiomics and Machine Learning in Medical Imaging
- RNA Interference and Gene Delivery
Ludwig-Maximilians-Universität München
2016-2025
LMU Klinikum
2016-2025
European Neuroendocrine Tumor Society
2020-2025
Charité - Universitätsmedizin Berlin
2001-2023
University of Glasgow
2018
Schiller International University
2009-2014
Friedrich Schiller University Jena
2009-2014
Jena University Hospital
2009-2013
University of Verona
2013
The Kinghorn Cancer Centre
2013
Patients with soft tissue sarcoma are at risk for local recurrence and distant metastases despite optimal treatment. Preoperative anthracycline plus ifosfamide chemotherapy improves outcome in common histological subtypes.To analyze whether the previously reported improvement progression-free survival by adding regional hyperthermia to neoadjuvant translates into improved survival.Open-label, phase 3 randomized clinical trial evaluate efficacy toxic effects of hyperthermia. Adult patients...
Predicting the clinical outcome of cancer patients based on expression marker genes in their tumors has received increasing interest past decade. Accurate predictors and response to therapy could be used personalize thereby improve therapy. However, state art methods so far often found with limited prediction accuracy, reproducibility, unclear biological relevance. To address this problem, we developed a novel computational approach identify prognostic for that couples gene measurements from...
Abstract Objective Develop a consensus for the nomenclature and definition of adrenal histopathologic features in unilateral primary aldosteronism (PA). Context Unilateral PA is most common surgically treated form hypertension. Morphologic examination combined with CYP11B2 (aldosterone synthase) immunostaining reveals diverse lesions resected adrenals. Patients Methods Surgically removed adrenals (n = 37) from 90 patients operated 2015 to 2018 Munich, Germany, were selected represent broad...
Adenomatous colorectal polyps require endoscopic resection, as opposed to non-adenomatous hyperplastic polyps. This study aims evaluate the effect of artificial intelligence (AI)-assisted differentiation adenomatous and at CT colonography on radiologists' therapy management. Five board-certified radiologists evaluated images with all sizes morphologies retrospectively decided whether depicted required resection. After a primary unassisted reading based current guidelines, second access...
Activated leucocyte cell adhesion molecule (ALCAM) has been implicated in tumorigenesis and tumour progression of malignant melanoma prostate cancer.To clarify the expression patterns ALCAM colon cancer to correlate these with clinicopathological parameters, including patient survival.One hundred eleven colorectal carcinomas were immunostained for (clone MOG/07) using a standard detection system. Cytoplasmic membranous immunoreactivity scored semiquantitatively. Fisher's exact test, chi2...
The programmed cell death 4 gene (PDCD4), a newly identified transformation suppressor, was analysed in lung tumour lines and primary carcinomas. Reduced PDCD4 mRNA expression observed two immortalized 18 cancer by northern blot analysis. In the survey of tumours, cDNA poorly represented 47 tumours compared with normal tissue microarray analysis this poor representation significantly associated high-grade (G3) adenocarcinomas (p = 0.012). Immunohistochemical 124 carcinomas comprising all...
The bispecific T cell engager blinatumomab has shown encouraging clinical activity in B-precursor acute lymphoblastic leukemia (ALL). However, about half of relapsed/refractory patients do not respond to therapy. Here, we present the case a 32-year-old male patient with refractory ALL who was resistant treatment blinatumomab. Bone marrow immunohistochemistry revealed infiltrates and an increase programmed death-ligand 1 (PD-L1)-positive cells as potential immune escape mechanism. We were...
Nuclear relocation of STAT6 has been shown in tumours with NAB2-STAT6 fusion, and proposed as an ancillary marker for the diagnosis solitary fibrous (SFTs). The aim this study was to verify utility immunohistology diagnosing SFT.A total 689 formalin-fixed paraffin-embedded comprising 35 pleural SFTs 654 other mesenchymal were investigated expression using immunohistochemistry. Nine dedifferentiated liposarcomas (DDLSs) five also examined presence fusion at protein level proximity ligation...
Desmosomes are intercellular junctions that confer strong cell-cell adhesion, thus conferring resistance against mechanical stress on epithelial tissues. A body of evidence indicates decreased expression desmosomal proteins is associated with poor prognosis in various cancers. As a key component plaque proteins, the functional role desmoplakin (DSP) cancer not yet elucidated. Here, we reported anti-tumorigenic activity DSP non-small cell lung (NSCLC). We found by DNA methylation was...
Chondrosarcoma is the second most frequent primary malignant bone tumor. Treatment mainly based on surgery. In general, wide resection advocated at least in G2 and G3 tumors. But which margins should be achieved? Does localization as for example pelvis have a higher impact survival than surgical themselves?From 1982 to 2014, 87 consecutive patients were treated by resection. The margin was defined R0 (wide resection), R1 (marginal resection) or, R2 if tumor left intentionally. All followed...
Primary aldosteronism (PA) is frequently caused by a unilateral aldosterone-producing adenoma with PA-driver mutation. Unilateral adrenalectomy has high probability of short-term biochemical remission, but long-term postsurgical outcomes are relatively undefined. Our objective was to investigate the incidence recurrence PA in individuals remission.
The effects of sex hormones remain largely unexplored in pheochromocytomas and paragangliomas (PPGLs) gastroenteropancreatic neuroendocrine tumors (GEP-NETs). We evaluated the estradiol, progesterone, Dehydroepiandrosterone sulfate (DHEAS), testosterone on human patient-derived PPGL/GEP-NET primary culture cell viability (n = 38/n 12), performed next-generation sequencing immunohistochemical hormone receptor analysis PPGL tumor tissues 36). In PPGLs, estradiol progesterone (1 µm)...
Aldosterone-producing adenomas (APAs) are a major cause of primary aldosteronism, common form endocrine hypertension. Here, we demonstrate that Early Growth Response 1 (EGR1) plays dual role in adrenal cell biology, regulating both oxidative stress and aldosterone production. Using RNA sequencing RSL3-treated human cells spatial transcriptomics glands from patients with identify EGR1 as key gene associated RSL3-related APAs. We show silencing decreases increases CYP11B2 expression production...
Background: The prognosis of patients with advanced soft tissue sarcoma (STS) remains dismal. Trofosfamide (TRO) has been proposed as a well-tolerated oral maintenance therapy. This retrospective analysis aims to determine the value this Methods: Fifty-nine STS who received TRO therapy between 2016 and 2022 were reviewed analysed regarding clinical parameters outcomes. Results: median age was 48 years; most common histological subtype synovial (n = 22, 37%), 71% 42) presented metastatic...
OBJECTIVE. This prospective study was performed to compare the image quality, tumor delineation, and depiction of staging criteria on MRI prostate cancer at 1.5 3.0 T.
Survivin appears to function as an apoptosis inhibitor and a regulator of cell division during development tumorigenesis. Here we report the molecular characterization nucleocytoplasmic transport survivin its potential implications for We identified evolutionary conserved Crm1-dependent nuclear export signal (NES) in survivin. In dividing cells, NES is essential tethering survivin/Aurora-B kinase complex mitotic machinery, which turn be proper division. addition, seems required...
Aberrant activities of Janus kinase (JAK)/signal transducer and activator transcription (STAT) signalling pathways have been implicated in the development spread various cancer entities, among them colorectal carcinoma (CRC). Transcription factors STAT3 STAT1, both downstream effectors interleukin (IL)-6 its receptor, are involved growth developmental control CRC cells. Constituents network around IL-6 STAT activation discussed as potential biomarkers therapeutic targets CRC. By...
Transcriptional signatures are an indispensible source of correlative information on disease-related molecular alterations a genome-wide level. Numerous candidate genes involved in disease and factors predictive, as well prognostic, value have been deduced from such portraits, e.g. cancer. However, mechanistic insights into the regulatory principles governing global transcriptional changes lagging behind extensive compilations deregulated genes. To identify regulators transcriptome...
Liposarcomas are the second most common type of soft tissue sarcomas, 30-50% these myxoid subtype. The aim this retrospective study was to analyze local control rate, metastatic pattern and survival patients in a consecutive single-institution series.From 1983 2015, 43 with liposarcoma extremities trunk wall underwent resections. margin defined as R0 (wide) or R1 (marginal). Patients were followed for evidence recurrence distant metastasis. Overall recurrence-free calculated.The mean age...
Colorectal cancer is treated with antibodies blocking epidermal growth factor receptor (EGF-R), but therapeutic success limited. EGF-R stimulated by soluble ligands, which are derived from transmembrane precursors ADAM17-mediated proteolytic cleavage. In mouse intestinal models in the absence of ADAM17, tumorigenesis was almost completely inhibited, and few remaining tumors were low-grade dysplasia. RNA sequencing analysis demonstrated down-regulation STAT3 Wnt pathway components. Because on...