A5034213605- Adrenal and Paraganglionic Tumors
- Cancer, Hypoxia, and Metabolism
- Pituitary Gland Disorders and Treatments
- Neuroblastoma Research and Treatments
- Neuroendocrine Tumor Research Advances
- Liver physiology and pathology
- Glioma Diagnosis and Treatment
- Myasthenia Gravis and Thymoma
- Histone Deacetylase Inhibitors Research
- Peptidase Inhibition and Analysis
- Cancer, Lipids, and Metabolism
- Cancer Immunotherapy and Biomarkers
- Diphtheria, Corynebacterium, and Tetanus
- Metabolism, Diabetes, and Cancer
- Orthopedic Infections and Treatments
- Lung Cancer Treatments and Mutations
- PI3K/AKT/mTOR signaling in cancer
- Phagocytosis and Immune Regulation
- Economic and Social Issues
- Bacterial Identification and Susceptibility Testing
University Hospital of Zurich
2021-2025
University of Zurich
2023-2025
University Hospital Carl Gustav Carus
2023
Technische Universität Dresden
2023
Helmholtz-Zentrum Dresden-Rossendorf
2023
Universitätsklinikum Würzburg
2023
Ludwig-Maximilians-Universität München
2023
Spital Limmattal
2023
Pheochromocytomas and paragangliomas (PPGLs) with pathogenic mutations in the succinate dehydrogenase subunit B (SDHB) are associated a high metastatic risk. Somatostatin receptor 2 (SSTR2)-dependent imaging is most sensitive modality for SDHB-related PPGLs, suggesting that SSTR2 expression significant cell surface therapeutic biomarker of such tumors.Exploration relationship between immunoreactivity SDHB immunoreactivity, mutational status, clinical behavior PPGLs. Evaluation SSTR-based...
The effects of sex hormones remain largely unexplored in pheochromocytomas and paragangliomas (PPGLs) gastroenteropancreatic neuroendocrine tumors (GEP-NETs). We evaluated the estradiol, progesterone, Dehydroepiandrosterone sulfate (DHEAS), testosterone on human patient-derived PPGL/GEP-NET primary culture cell viability (n = 38/n 12), performed next-generation sequencing immunohistochemical hormone receptor analysis PPGL tumor tissues 36). In PPGLs, estradiol progesterone (1 µm)...
Abstract Context Treatment options for advanced neuroendocrine tumors (NETs), pheochromocytomas and paragangliomas (PPGLs) are still limited. In recent years, antitumor effects of cannabinoids have been reported; however, there only very limited data available in NETs or PPGLs. Objective Investigation the cannabidiol (CBD) on patient-derived human NET/PPGL primary cultures cell lines. Methods We established derived from 46 different patients with PPGLs (n = 35) 11) who underwent tumor...
Abstract Context Pheochromocytomas and paragangliomas (PPGLs) are rare endocrine tumors that frequently produce catecholamines. Catecholamine-induced cardiometabolic complications substantially contribute to increased morbidity mortality in PPGL patients prior surgical resection. Objective To determine whether markers of elevated risk persist following Design Retrospective analysis a multicenter cohort with PPGLs participating the prospective ProsPheo study ENS@T registry. Methods...
Introduction: Peptide receptor radionuclide therapy (PRRT) is a highly effective, targeted treatment option in advanced neuroendocrine tumours (NETs). However, NET patients expressing low levels of Somatostatin type (SSTR)2 do not benefit from this powerful tool. Recently, several preclinical studies have revealed that histone deacetylase (HDAC) inhibitors can upregulate the expression SSTR2 and enhance somatostatin ligand binding to tumour cells. In study, we explored effects single...
Abstracts Background Somatostatin-receptor (SSTR)—targeting PET/CT is widely used for diagnosis and disease monitoring of pheochromocytoma / paraganglioma (PPGL). The aim this study was to assess the potential novel SSTR-targeting tracer [ 18 F]SiTATE in diagnosing PPGL by comparing imaging parameters tumor marker levels secretory activity a small cohort patients diagnosed with rare type. Methods This retrospective included 34 histologically confirmed who underwent F]SiTATE-PET/CT at LMU...
The therapeutic options for metastatic pheochromocytomas/paragangliomas (mPPGLs) include chemotherapy with cyclophosphamide/vincristine/dacarbazine (CVD), temozolomide monotherapy, radionuclide therapies, and tyrosine kinase inhibitors such as sunitinib. objective of this multicenter retrospective study was to evaluate compare the responses mPPGLs including those pathogenic variants in succinate dehydrogenase subunit B (SDHB), different systemic treatments.This is a analysis treatment mPPGL...
Radionuclide therapies are an important tool for the management of patients with neuroendocrine neoplasms (NENs). Especially [
Hypoxia activates pathways associated with tumor progression, metastatic spread, and alterations in the immune microenvironment leading to an immunosuppressive phenotype. In particular, upregulation of PD-L1, a target for therapy checkpoint inhibitors, is well-studied several tumors. However, relationship between hypoxia PD-L1 regulation pheochromocytomas paragangliomas (PPGL), especially treated embolization, still largely unexplored. We investigated expression hypoxia-marker HIF-2α...
Purpose Hypophysitis occurs in up to 10% of patients treated with immune-checkpoint inhibitors (ICIs). MRI shows no abnormalities the pituitary gland one third patients. A delayed diagnosis increases risk for life-threatening adrenal crisis, underscoring need early detection. This study evaluates diagnostic accuracy FDG PET/CT detecting ICI-induced hypophysitis a cohort melanoma Materials and Methods Patients metastatic hypophysitis, who underwent 90 days before 10 after diagnosis, were...
Mesenchymal-to-epithelial transition (MET) exon 14 skipping mutations and MET gene amplification occur in 3–5% of non-small cell lung cancer (NSCLC) patients. Tyrosine kinase inhibitors (TKIs) targeting alterations have shown promising results these The aim this study was to describe the genomic profile, PD-L1 expression clinicopathological features dysregulated NSCLC. We identified 188 patients with advanced-stage NSCLC data on by immunohistochemistry (IHC). IHC for performed 131 patient...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Rothia spp.are gram-positive bacteria that are part of the normal human oral and gut microbiome.They mainly cause opportunistic infections in immunocompromised hosts associated with periodontal disease.Here, we present a rare case septic arthritis native knee due to mucilaginosa 66-year-old, immunocompetent, male patient osteoarthritis both knees.Intra-articular corticosteroid injection was identified as most likely source infection.We discuss increase iatrogenic joint caused by...
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