A5074139916- Hormonal Regulation and Hypertension
- Adrenal and Paraganglionic Tumors
- Adrenal Hormones and Disorders
- Pituitary Gland Disorders and Treatments
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Electrolyte and hormonal disorders
- Cancer, Hypoxia, and Metabolism
- Scientific Computing and Data Management
- Ion Transport and Channel Regulation
- Blood Pressure and Hypertension Studies
- Graph Theory and Algorithms
- Neural Networks and Applications
- Cancer, Lipids, and Metabolism
- Ferroptosis and cancer prognosis
- Helicobacter pylori-related gastroenterology studies
- Drug Transport and Resistance Mechanisms
- Gastroesophageal reflux and treatments
- Vitamin K Research Studies
- Stress Responses and Cortisol
- Neuroblastoma Research and Treatments
- Bone Tumor Diagnosis and Treatments
- RNA Research and Splicing
- Body Composition Measurement Techniques
- Reproductive System and Pregnancy
- Renal function and acid-base balance
University of Zurich
2017-2025
University Hospital of Zurich
2013-2025
Universitätsklinik für Diabetologie, Endokrinologie, Ernährungsmedizin & Metabolismus
2020
During active inflammation, intraluminal intestinal pH is decreased in patients with inflammatory bowel disease [IBD]. Acidic may play a role IBD pathophysiology. Recently, proton-sensing G-protein coupled receptors were identified, including GPR4, OGR1 [GPR68], and TDAG8 [GPR65]. We investigated whether GPR4 involved inflammation.The of was assessed murine colitis models by chronic dextran sulphate sodium [DSS] administration cross-breeding into an IL-10 deficient background for development...
Diagnosis of primary aldosteronism (PA) for many patients depends on positive results the saline infusion test (SIT). Plasma aldosterone is often measured by immunoassays, which can return inaccurate results.This study aimed to establish whether differences in measurements immunoassay versus mass spectrometry (MS) might impact confirmatory testing PA.This study, involving 240 tested using SIT at 5 tertiary care centers, assessed discordance between and MS-based plasma aldosterone.Plasma...
Tissue inflammation in inflammatory bowel diseases [IBD] is associated with local acidification. Genetic variants the pH-sensing G protein-coupled receptor 65, also known as T cell death-associated gene 8 [TDAG8], have been implicated IBD and other autoimmune diseases. Since role of TDAG8 intestinal remains unclear, we investigated function using murine colitis models.The effects deficiency were assessed dextran sodium sulphate [DSS], IL-10-/-, transfer models. RNA sequencing...
Abstract Objective Primary aldosteronism (PA) is one of the most frequent causes secondary hypertension. Although clinical practice guidelines recommend a diagnostic process, details steps remain incompletely standardized. Design In present SCOT-PA survey, we have investigated diversity approaches utilized for each step in different expert centers through survey using Google questionnaires. A total 33 from 3 continents participated. Results We demonstrated prominent conditions blood...
Abstract Context Pheochromocytomas and paragangliomas (PPGLs) are rare endocrine tumors that frequently produce catecholamines. Catecholamine-induced cardiometabolic complications substantially contribute to increased morbidity mortality in PPGL patients prior surgical resection. Objective To determine whether markers of elevated risk persist following Design Retrospective analysis a multicenter cohort with PPGLs participating the prospective ProsPheo study ENS@T registry. Methods...
Measurements of aldosterone by mass spectrometry are more accurate and less prone to interferences than immunoassay measurements, may produce a aldosterone:renin ratio (ARR) when screening for primary aldosteronism (PA).
Introduction Endocrine hypertension (EHT) due to pheochromocytoma/paraganglioma (PPGL), Cushing’s syndrome (CS), or primary aldosteronism (PA) is linked a variety of metabolic alterations and comorbidities. Accordingly, patients with EHT (PHT) are characterized by distinct profiles. However, it remains unclear whether the metabolomic differences relate solely disease-defining hormonal parameters. Therefore, our objective was study association disease defining excess concomitant adrenal...
Abstract Context Sampling of blood in the supine position for diagnosis pheochromocytoma and paraganglioma (PPGL) results lower rates false positives plasma normetanephrine than seated sampling. It is unclear how inpatient vs outpatient testing other preanalytical factors impact positives. Objective We aimed to identify precautions minimize false-positive metanephrines. Methods Impacts different sampling conditions on metanephrines were evaluated, including testing, semi- fully recumbent...
BACKGROUND: Diagnosis of primary aldosteronism (PA) is complicated by the need to withdraw antihypertensive medications that interfere with test results, particularly renin. This study examined whether machine learning-based steroid-probability scores offer a renin measurement-independent approach for testing less prone interference than aldosterone-to-renin ratio (ARR). METHODS: prospective multicenter cohort involved use plasma steroidomics and ARR in 839 patients tested PA, including 190...
BACKGROUND: Distinguishing between unilateral and bilateral primary aldosteronism, a major cause of secondary hypertension, is crucial due to different treatment approaches. While adrenal venous sampling the gold standard, its invasiveness, limited availability, often difficult interpretation pose challenges. This study explores utility circulating microRNAs (miRNAs) machine learning in distinguishing forms aldosteronism. METHODS: MiRNA profiling was conducted on plasma samples from 18...
In vitro and in vivo data have shown that retinoid treatment promotes an anti-inflammatory milieu with few adverse effects toward the gastrointestinal tract. The studies reported here further evaluate 2 mouse models of inflammatory bowel disease.Chronic dextran sulfate sodium colitis was induced age- weight-matched C57Bl/6 mice by 4 cycles administration (6-8 animals/group). At cycle 4, animals were administered 13-cis-retinoic acid (isotretinoin, 30 mg/kg) or vehicle (oral gavage)...
Abstract Hypokalemia plays an important role in the diagnosis and management of primary aldosteronism (PA). While hypokalemic variant disease accounts for about one third all cases, little is known incidence PA populations. The IPAHK+ study epidemiological, cross-sectional trial to provide evidence on patients from a university hospital outpatient population. Recruitment outpatients with hypokalemia≤3 mmol/l carried out continuous referral-basis through automated data delivery system. Up...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Abstract Background and Aims Primary aldosteronism (PA) is one of the most frequent causes secondary hypertension. Patients with PA are at higher risk for cardiovascular renal complications than those essential Screening rarely considered in assessment a hypertensive patient, part because difficulties diagnostic process. Nevertheless, identification crucial to guide patients towards optimal management, either by mineralocorticoid receptor blockade or unilateral adrenalectomy, latter offering...
Abstract Disclosure: B. Vekony: None. G. Nyiro: Z. Herold: J. Fekete: F. Ceccato: S. Gruber: L. Kurzinger: M. Parasiliti-Caprino: Szeredas: S.K. Nazri: V. Fell: Bassiony: E.A. Azizan: I. Bancos: Beuschlein: P. Igaz: Background: The differentiation of uni- and bilateral forms primary aldosteronism (PA) is pivotal clinical relevance. Whereas unilateral PA warrants surgical treatment, treated by aldosterone antagonists. most reliable way to differentiate these two entities adrenal venous...
Abstract Disclosure: B. Vekony: None. G. Nyiro: Z. Herold: J. Fekete: F. Ceccato: S. Gruber: L. Kurzinger: M. Parasiliti-Caprino: Szeredas: Syed Mohammed Nazri: V. Fell: Bassiony: E.A. Azizan: I. Bancos: Beuschlein: P. Igaz: Background: The differentiation of uni- and bilateral forms primary aldosteronism (PA) is pivotal clinical relevance. Whereas unilateral PA warrants surgical treatment, treated by aldosterone antagonists. most reliable way to differentiate these two entities adrenal...
Abstract Disclosure: S. Gruber: None. D. Kirschenbaum: T. Hortobagyi: C. Serra: A. Bink: F. Beuschlein: Z. Erlic: Background: Pituitary adenomas account for about 15% of all intracranial neoplasms and typically arise from monoclonal proliferation anterior pituitary cells. While lactotropic clinically hormone-inactive make up by far the largest proportion, somatotropic corticotropic have a significantly lower prevalence. This case describes very rare finding gonadotropic double adenoma....
Hypokalemia plays a central role for case finding, course, treatment decision, and prognosis of patients with primary aldosteronism. However, to date there is lack high-level evidence about the incidence aldosteronism in hypokalemic patients. The IPAHK+study an epidemiological, cross-sectional, monocentric study provide on PA population. aim current analysis was describe baseline characteristics first 100 eligible inclusion. recruitment hypokalemia (≤3 mmol/l) carried out continuously...