A5021707048- Ion Transport and Channel Regulation
- Parathyroid Disorders and Treatments
- Magnesium in Health and Disease
- Renal function and acid-base balance
- Metabolism and Genetic Disorders
- Amino Acid Enzymes and Metabolism
- Genetic Syndromes and Imprinting
- Biomedical Research and Pathophysiology
- Ion channel regulation and function
- ATP Synthase and ATPases Research
- Electrolyte and hormonal disorders
- Dialysis and Renal Disease Management
- Neonatal Health and Biochemistry
- Genetic and Kidney Cyst Diseases
- Mitochondrial Function and Pathology
- Kidney Stones and Urolithiasis Treatments
- Renal and related cancers
- Hormonal Regulation and Hypertension
- Cardiac Arrhythmias and Treatments
- Diet and metabolism studies
- Medical Imaging and Pathology Studies
- Drug Transport and Resistance Mechanisms
- Adrenal Hormones and Disorders
- Erythrocyte Function and Pathophysiology
- Pediatric Urology and Nephrology Studies
University of Zurich
2016-2025
Czech Academy of Sciences, Institute of Physiology
1999-2025
FORS – Swiss Centre of Expertise in the Social Sciences
2016-2024
von Hoerner & Sulger (Germany)
2022-2024
Target (United States)
2023-2024
Center for Pediatric Endocrinology Zurich
2023
University Hospital of Lausanne
2022
Swiss Integrative Center for Human Health
2011-2020
University of Applied Sciences and Arts Hildesheim/Holzminden/Göttingen
2020
RELX Group (United States)
2018-2020
Idiopathic infantile hypercalcemia (IIH) is characterized by severe with failure to thrive, vomiting, dehydration, and nephrocalcinosis. Recently, mutations in the vitamin D catabolizing enzyme 25-hydroxyvitamin D3-24-hydroxylase (CYP24A1) were described that lead increased sensitivity due accumulation of active metabolite 1,25-(OH)2D3. In a subgroup patients who presented early infancy renal phosphate wasting symptomatic hypercalcemia, CYP24A1 excluded. Four from families parental...
Klotho and fibroblast growth factor 23 (FGF23) are key regulators of mineral metabolism in renal insufficiency. FGF23 levels have been shown to increase early chronic kidney disease (CKD); however, the corresponding soluble at different CKD stages not known. Soluble Klotho, FGF23, parathyroid hormone (PTH), 1,25-dihydroxy vitamin D3 (1,25D) other parameters were measured an observational cross-sectional study 87 patients. Locally weighted scatter plot smoothing function these plotted versus...
Blood gas and tissue pH regulation depend on the ability of brain to sense CO2 and/or H(+) alter breathing appropriately, a homeostatic process called central respiratory chemosensitivity. We show that selective expression proton-activated receptor GPR4 in chemosensory neurons mouse retrotrapezoid nucleus (RTN) is required for CO2-stimulated breathing. Genetic deletion disrupted acidosis-dependent activation RTN neurons, increased apnea frequency, blunted ventilatory responses CO2....
Hartnup amino acid transporter B(0)AT1 (SLC6A19) is the major luminal sodium-dependent neutral of small intestine and kidney proximal tubule. The expression in was recently shown to depend on its association with collectrin (Tmem27), a protein homologous membrane-anchoring domain angiotensin-converting enzyme (ACE) 2.Because almost absent from intestine, we tested hypothesis that it ACE2 interacts enterocytes. Furthermore, because depends an associated protein, Hartnup-causing mutations...
Glutamine release from astrocytes is an essential part of the glutamate-glutamine cycle in brain. Uptake glutamine into cultured rat occurs by at least four different routes. In agreement with earlier studies, a significant contribution amino acid transport systems ASC, A, L, and N was detected. It has not been determined whether these are also involved efflux or specific transporters exist. We show here that ASCT2, variant system strongly expressed astroglia-rich primary cultures but...
Transforming growth factor β (TGF-β) has been shown to participate in the pathophysiology of diabetic complications. As most recently, TGF-β stimulates expression a distinct serine/threonine kinase (hSGK) which had previously cloned as an early gene transcriptionally regulated by cell volume alterations. The present study was performed elucidate transcription and function hSGK nephropathy. Northern blotting, increase extracellular glucose concentration increased mRNA levels cultured cells,...
An environmental and epidemiological study has been carried out in Central Cappadocia, Turkey, aiming at investigating the relationship between exposure to naturally occurring erionite fibres reported high incidence of malignant mesotheliomas. Airborne fibre levels are generally low but show a higher proportion villages affected by disease than control village. The same pattern is confirmed analysis content lung tissues sheep from several villages, both unaffected disease. 3 with highest...
The cationic amino acid arginine, due to its positive charge, is usually accumulated in the cytosol. Nevertheless, arginine has be released by a number of cell types, e.g. kidney cells, which supply other organs with this acid, or endothelial cells blood–brain barrier release into brain. Arginine mammalian can mediated two different transporters, y+LAT1 and y+LAT2. For insertion plasma membrane, these transporters have associated type-II membrane glycoprotein 4F2hc [Torrents, Estevez,...
The inhibitory programmed death 1 (PD-1)–programmed ligand (PD-L1) pathway contributes to the functional down-regulation of T cell responses during persistent systemic and local virus infections. blockade PD-1–PD-L1–mediated inhibition is considered as a therapeutic approach reinvigorate antiviral responses. Yet previous studies reported that PD-L1–deficient mice develop fatal pathology early lymphocytic choriomeningitis (LCMV) infection, suggesting host protective role down-regulation. As...
Organic anion transporting polypeptides (humans OATPs, rodents Oatps) are expressed in most mammalian tissues and mediate cellular uptake of a wide variety amphipathic organic compounds such as bile salts, steroid conjugates, oligopeptides, large list drugs, probably by acting exchangers. In the present study we aimed to investigate role extracellular pH on transport activity nine human four rat OATPs/Oatps. Furthermore, test concept that OATP/Oatp is accompanied extrusion bicarbonate. By...
Tubular epithelial injury represents an underestimated but important cause of renal dysfunction in patients with cholestasis and advanced liver disease, the underlying mechanisms are unclear. To address hypothesis that accumulation excessive alternative urinary elimination potentially toxic bile acids (BAs) may contribute to kidney cholestasis, we established a mouse model for detailed vivo time course as well treatment studies. Three-day common duct ligation (CBDL) induced tubular...