A5049632995- Moyamoya disease diagnosis and treatment
- Per- and polyfluoroalkyl substances research
- Toxic Organic Pollutants Impact
- Cerebrovascular and genetic disorders
- Carcinogens and Genotoxicity Assessment
- Folate and B Vitamins Research
- Wood Treatment and Properties
- Tree Root and Stability Studies
- Metabolism and Genetic Disorders
- Air Quality and Health Impacts
- Forest ecology and management
- Pancreatic function and diabetes
- Endoplasmic Reticulum Stress and Disease
- Effects and risks of endocrine disrupting chemicals
- Amino Acid Enzymes and Metabolism
- Connective tissue disorders research
- Atmospheric chemistry and aerosols
- Intracranial Aneurysms: Treatment and Complications
- Adipose Tissue and Metabolism
- Mitochondrial Function and Pathology
- Genetics, Aging, and Longevity in Model Organisms
- Health, Environment, Cognitive Aging
- Neurological Complications and Syndromes
- Drug-Induced Hepatotoxicity and Protection
- Sulfur Compounds in Biology
Kyoto Prefectural Institute of Public Health and Environment
2015-2025
Kyoto University
2015-2024
Sichuan University
2022
Sirindhorn College of Public Health
2022
Faculty of Public Health
2022
Gunma Chuo Hospital
2022
Jikei University School of Medicine
2019-2021
Social Welfare Department
2020-2021
Kyoto College of Medical Science
2009-2021
Waseda University
2020
Overload of pancreatic β cells in conditions such as hyperglycemia, obesity, and long-term treatment with sulfonylureas leads to cell exhaustion type 2 diabetes. Because mass declines under these conditions, apparently a result apoptosis, we speculated that overload kills endoplasmic reticulum (ER) stress. The Akita mouse, which carries conformation-altering missense mutation (Cys96Tyr) Insulin 2, likewise exhibits hyperglycemia reduced mass. In the development diabetes mice, mRNAs for ER...
Overload of pancreatic β cells in conditions such as hyperglycemia, obesity, and long-term treatment with sulfonylureas leads to cell exhaustion type 2 diabetes. Because mass declines under these conditions, apparently a result apoptosis, we speculated that overload kills endoplasmic reticulum (ER) stress. The Akita mouse, which carries conformation-altering missense mutation (Cys96Tyr) Insulin 2, likewise exhibits hyperglycemia reduced mass. In the development diabetes mice, mRNAs for ER...
Hereditary hemorrhagic telangiectasia (HHT or Rendu-Osler-Weber syndrome) is an autosomal dominant disorder characterized by aberrant vascular development. We report here a genetic epidemiologic study in county, A, the Akita prefecture (population 1.2 million) located northern Japan. Nine HHT patients who had been referred to tertiary-care hospitals were and near county. A total of 137 pedigree members traced which 81 alive 32 affected HHT. Complications associated with cerebral pulmonary...
Perfluorooctanoate and Perfluorooctane Sulfonate Concentrations in Surface Water Japan: Norimitsu Saito, et al. Institute for Environmental Sciences Public Health of Iwate Prefecture —Perfluorooctanoate (PFOA) perfluorooctane sulfonate (PFOS) are synthetic surfactants used Japan. An epidemiological study workers exposed to PFOA revealed a significant increase prostate cancer mortality. A cross‐sectional PFOA‐exposed showed that perturbs sex hormone homeostasis. We analyzed their...
Background— Perceived mental stress has been associated with risk of coronary heart disease (CHD) in white men, but no prospective data are available for other ethnic groups. Methods and Results— From 1988 to 1990, a total 73 424 Japanese (30 180 men 43 244 women), aged 40 79 years, without history stroke, CHD, or cancer completed lifestyle questionnaire including perception under the Japan Collaborative Cohort Study Evaluation Cancer Risk Sponsored by Monbusho (JACC Study). Systematic...
<h3>Background</h3> The effects of coffee and green, black oolong teas caffeine intake on cardiovascular disease (CVD) mortality have not been well defined in Asian countries. <h3>Methods</h3> To examine the relationship between consumption these beverages risk from CVD, 76 979 individuals aged 40–79 years free stroke, coronary heart (CHD) cancer at entry were prospectively followed. daily was assessed by questionnaires. <h3>Results</h3> 1362 deaths documented strokes 650 CHD after 1 010 787...
Blood and/or breast milk have been used to assess human exposure various environmental contaminants. Few studies available compare the concentrations in one matrix with those another. The goals of this study were determine current levels polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) Japanese women, analysis effects lifestyle dietary habits on these levels, develop a quantitative structure-activity relationship (QSAR) which predict ratio serum concentration...
This study prospectively examined the association between shift work and risk of ischemic heart disease among Japanese male workers. A baseline survey, which involved 110,792 inhabitants (age range: 40–79 years) from 45 areas throughout Japan, was conducted 1988 1990. The causes death were identified certificates. analysis restricted to 17,649 men 40–59 who employed at time survey. All subjects asked indicate most regular that they had undertaken previously: day work, rotating-shift or...
Arginine rich, mutated in early stage of tumors (ARMET) was first identified as a human gene highly variety cancers. However, little is known about the characteristics ARMET protein and its expression. We upregulated by endoplasmic reticulum (ER) stress. Here, we show that mouse homologue an 18-kDa soluble ER mature after cleavage signal sequence has four intramolecular disulfide bonds, including two CXXC sequences. stress stimulated expression, expression patterns mRNA tissues were similar...
Moyamoya disease (MMD) is an idiopathic steno-occlusive cerebrovascular that represents important cause of stroke. However, etiology the has remained largely unknown.We previously showed inheritance pattern MMD autosomal dominant with incomplete penetrance. Here, we report genome-wide parametric linkage analysis for in 15 extended Japanese families. We conducted analyses under two diagnostic classifications: narrow and broad. Affected member-only was applied due to age-dependent penetrance...
To examine the association of plant-based food intakes with CVD and total mortality among Japanese. In Japan Collaborative Cohort Study for Evaluation Cancer Risk, 25 206 men 34 279 women aged 40–79 years, whose fruit, vegetable bean were assessed by questionnaire at baseline in 1988–90, followed 13 years. Deaths from stroke, stroke subtypes, CHD CVD, according to International Classification Diseases 10th Revision, registered. During 756 054 person-years follow-up, there 559 deaths 258 CHD,...
Significance There is a potential risk of human exposure to radiation owing the March 2011 Fukushima Daiichi Nuclear Power Plant accident. In this study, we evaluated dose rates from deposited radiocesium in three areas neighboring restricted and evacuation Fukushima. The mean annual rate 2012 associated with accident was 0.89–2.51 mSv/y. estimates 2022 are comparable variations average 2 mSv/y background natural radionuclides Japan. Furthermore, extra lifetime integrated after estimated...
Serum free-carnitine levels were determined in 973 unrelated white collar workers Akita, Japan. Fourteen of these participants consistently had serum below the fifth percentile (28 µM for females and 38 males). The OCTN2 (organic cation transporter) gene was sequenced 14 subjects, 22 subjects whose carnitine first screening but normal second measurement 69 individuals with two separate measurements. Polymorphic sequences defined three major haplotypes equal frequency. Mutations identified...