A5036643048- Hormonal Regulation and Hypertension
- Adrenal Hormones and Disorders
- Pituitary Gland Disorders and Treatments
- Amino Acid Enzymes and Metabolism
- Metabolism and Genetic Disorders
- Stress Responses and Cortisol
- Diet and metabolism studies
- Hormonal and reproductive studies
- Drug Transport and Resistance Mechanisms
- Cancer, Lipids, and Metabolism
- Hemoglobin structure and function
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Chemical Reactions and Isotopes
- Infrared Thermography in Medicine
- Cancer-related cognitive impairment studies
- Antibiotics Pharmacokinetics and Efficacy
- Body Composition Measurement Techniques
- Adrenal and Paraganglionic Tumors
- ATP Synthase and ATPases Research
- Biochemical and Molecular Research
- Vitamin D Research Studies
- Pharmacogenetics and Drug Metabolism
Mayo Clinic in Arizona
2023-2025
Mayo Clinic
2024
WinnMed
2024
Medical Research Council
1975-1979
Agricultural Research Service
1976
United States Department of Agriculture
1976
The effects of varying dietary protein intake, and supplements ornithine, arginine, lysine, proline on a patient with hyperornithinemia, hyperammonemia, homocitrullinuria were investigated in an attempt to understand the condition. homocitrulline excretion is increased also by intake. Supplementary ornithine or arginine lowers plasma ammonia levels simultaneously decreases homocitrulline. A possible cause this disease defect transport into mitochondria. Arginine may be useful treatment
Rats metabolized single oral doses of O,O-diethyl-O(3,5,6-trichloro-2-pyridyl-2,6-14C) phosphorothioate to at least six radiolabeled urinary metabolites. The urine contained about 90 percent the dose. Three these metabolites were identified as glucuronide 3,5,6-trichloro-2-pyridinol (80% 14C), a glycoside (4%), and (12%).
Abstract Objective Glucocorticoid withdrawal syndrome (GWS) may develop in patients following successful surgery for endogenous hypercortisolism. Effective strategies to minimize GWS and improve quality of life (QoL) are currently lacking. We aimed determine the impact hydrocortisone versus prednisone therapy on QoL during first 12 weeks post-surgery. Methods Single-center prospective cohort study (2019-2024) adults with hypercortisolism who developed post-operative adrenal insufficiency...
Abstract Context Patients with nonfunctioning adenomas (NFAs), mild autonomous cortisol secretion (MACS) and Cushing syndrome (CS) demonstrate an increased cardiovascular risk. Objective This work aimed to determine the extent of lipoprotein abnormalities in NFA, MACS, CS. Methods We conducted a single-center, cross-sectional study patients NFA (n = 167), MACS 213), CS 142), referent individuals 202) between January 2015 July 2022. Triglyceride-rich particles (TRLP), low-density (LDLP),...
BACKGROUND: Distinguishing between unilateral and bilateral primary aldosteronism, a major cause of secondary hypertension, is crucial due to different treatment approaches. While adrenal venous sampling the gold standard, its invasiveness, limited availability, often difficult interpretation pose challenges. This study explores utility circulating microRNAs (miRNAs) machine learning in distinguishing forms aldosteronism. METHODS: MiRNA profiling was conducted on plasma samples from 18...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Patients with mild autonomous cortisol secretion (MACS) have a high risk of fractures, discordant to the degree bone mineral density (BMD) loss. Increased fractures may be due impaired quality. Previous cross-sectional studies demonstrated that trabecular score (TBS), DXA-based measurement correlates parameters microstructure, was lower in MACS vs referent subjects. The impact adrenalectomy on TBS has not been characterized patients MACS. Thus, we aimed determine and BMD. In this...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Abstract Context Mild autonomous cortisol secretion (MACS) is diagnosed based on postdexamethasone >1.8 µg/dL. Scarce evidence exists steroid circadian and metabolome in MACS. Objective To characterize 24-hour (h) urine patients with MACS determine differences profiling concentrations vs referent subjects. Methods Cross-sectional study, 2018-2023, at a referral center. Patients age-, sex-, body mass index–, menopausal status–matched subjects were included. Urine was collected over 24...
Abstract Disclosure: J. Saini: None. R. Nathani: Larson: V. Fell: I. Bancos: Background: Surgical menopause due to bilateral salpingo-oophorectomy (BSO) at a younger age is associated with an increased risk of cardiovascular disease, cognitive decline, and mortality. Aging abnormalities in steroid metabolome, most notably glucocorticoid androgen ratio (“adrenal aging”). We hypothesized that postmenopausal women the same age, duration adrenal aging. Objective: To determine differences...
Abstract Disclosure: J. Saini: None. V. Fell: B. Atkinson: S. Achenbach: I. Bancos: Background: Patients with mild autonomous cortisol secretion (MACS) have a higher prevalence of frailty and reduced muscle strength as compared to patients nonfunctioning adrenal adenomas or subjects without disorders. Objective: To determine the impact adrenalectomy on parameters functional in MACS. Methods: We conducted single-center prospective longitudinal study adults MACS scheduled for referent...
Abstract Disclosure: B. Vekony: None. G. Nyiro: Z. Herold: J. Fekete: F. Ceccato: S. Gruber: L. Kurzinger: M. Parasiliti-Caprino: Szeredas: S.K. Nazri: V. Fell: Bassiony: E.A. Azizan: I. Bancos: Beuschlein: P. Igaz: Background: The differentiation of uni- and bilateral forms primary aldosteronism (PA) is pivotal clinical relevance. Whereas unilateral PA warrants surgical treatment, treated by aldosterone antagonists. most reliable way to differentiate these two entities adrenal venous...
Abstract Disclosure: B. Vekony: None. G. Nyiro: Z. Herold: J. Fekete: F. Ceccato: S. Gruber: L. Kurzinger: M. Parasiliti-Caprino: Szeredas: Syed Mohammed Nazri: V. Fell: Bassiony: E.A. Azizan: I. Bancos: Beuschlein: P. Igaz: Background: The differentiation of uni- and bilateral forms primary aldosteronism (PA) is pivotal clinical relevance. Whereas unilateral PA warrants surgical treatment, treated by aldosterone antagonists. most reliable way to differentiate these two entities adrenal...
Abstract Disclosure: J. Saini: None. C.D. Zhang: V. Fell: E. Atkinson: S. Achenbach: I. Bancos: Background: Several studies employing computed tomography (CT) scans for body composition measurements have reported lower muscle mass and a higher proportion of visceral fat in patients with mild autonomous cortisol secretion (MACS) compared to referent subjects. While CT scan assesses adipose tissue (VAT) at single slice level (L3), no evaluated the overall VAT MACS using Dual-Energy X-ray...
Abstract Disclosure: J. Saini: None. S. Singh: A.L. Ebbehøj: C.D. Zhang: R. Nathani: V. Fell: E. Atkinson: Achenbach: A. Rivard: R.J. S.K. Grebe: I. Bancos: Context: Mild autonomous cortisol secretion (MACS) is diagnosed based on post-dexamethasone cortisol>1.8 mcg/dL. Scarce evidence exists steroid circadian and metabolome in MACS. Objective: To characterize 24-hour urine patients with MACS determine differences profiling concentrations versus referent subjects. Design:...
Abstract Disclosure: B. Salama: None. J. Saini: V. Fell: E.J. Atkinson: S.J. Achenbach: Background: Mildly autonomous cortisol secretion (MACS) can be unilateral in 80% of cases, or bilateral 20% due to either adrenal adenomas macronodular hyperplasia. Scarce evidence demonstrates the differences plasma steroid profiling patients with versus MACS, however, these findings have not been confirmed using a more comprehensive 24h urine profiling. Objectives: To characterize metabolome and MACS....
Abstract Disclosure: J. Saini: None. R. Nathani: Larson: V. Fell: I. Bancos: Background: Surgical menopause due to bilateral salpingo-oophorectomy (BSO) at a younger age is associated with an increased risk of cardiovascular disease, cognitive decline, and mortality. Aging abnormalities in steroid metabolome, most notably glucocorticoid androgen ratio (“adrenal aging”). We hypothesized that postmenopausal women the same age, duration adrenal aging. Objective: To determine differences...
Abstract Disclosure: E.Y. Ferreira: None. J. Saini: Larson: E. Atkinson: C. Powell: S. Nevin: V. Fell: I. Bancos: Grant Recipient; Self; HRA Pharmaceuticals. Research Investigator; Context: Mild autonomous cortisol secretion (MACS) is the most prevalent hormonal abnormality demonstrated in 20-45% of patients with adrenal adenomas. MACS associated increased prevalence and incidence cardiovascular morbidity, frailty, fragility fractures, psychiatric sleep disorders, as well mortality....
Abstract Disclosure: J. Saini: None. V. Fell: B. Atkinson: S. Achenbach: I. Bancos: Background: Patients with mild autonomous cortisol secretion (MACS) have an impaired quality of life and a higher prevalence sleep mood disturbances as compared to patients nonfunctioning adrenal adenomas. The impact adrenalectomy on life, mood, is unclear. Objective: To determine the sleep, in MACS Methods: We conducted single-center prospective longitudinal study adults scheduled for referent subjects...
The impact of mild autonomous cortisol secretion (MACS) on cognition is incompletely characterized. We aimed to assess in patients with MACS, identify factors associated lower cognition, and determine the adrenalectomy cognition.
Abstract Disclosure: J. Saini: None. R. Nathani: C. Zhang: M. Suresh: K. Thangamuthu: S. Singh: V. Fell: E.J. Atkinson: Achenbach: N.H. Stricker: I. Bancos: Background: Patients with mild autonomous cortisol secretion (MACS) have impaired cognition compared to patients non-functioning adrenal adenomas. However, the impact of adrenalectomy on cognitive function in MACS is unclear. Objective: To determine MACS. Methods: Single-center prospective longitudinal study adults was defined as serum...