A5022918107- Hormonal Regulation and Hypertension
- Adrenal and Paraganglionic Tumors
- Cancer, Hypoxia, and Metabolism
- Hormonal and reproductive studies
- Acute Ischemic Stroke Management
- Advanced MIMO Systems Optimization
- Cardiovascular Health and Disease Prevention
- Cerebrovascular and Carotid Artery Diseases
- Pituitary Gland Disorders and Treatments
- Diet and metabolism studies
- Prostate Cancer Treatment and Research
- Histiocytic Disorders and Treatments
- Cooperative Communication and Network Coding
- Growth Hormone and Insulin-like Growth Factors
- Cancer, Lipids, and Metabolism
- Vascular anomalies and interventions
- Parvovirus B19 Infection Studies
- Congenital Heart Disease Studies
- AI in cancer detection
- Adrenal Hormones and Disorders
- Estrogen and related hormone effects
- Viral-associated cancers and disorders
- Coronary Artery Anomalies
- Nutritional Studies and Diet
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
Sichuan University
2010-2025
Mayo Clinic in Arizona
2022-2025
Mayo Clinic
2022-2025
China Medical University
2017-2024
Nanjing University
2024
West China Hospital of Sichuan University
2019-2024
First Hospital of China Medical University
2017-2024
WinnMed
2024
Renji Hospital
2022
Sherman Hospital
2022
Human papillomavirus vaccination and cervical screening are lacking in most lower resource settings, where approximately 80% of more than 500 000 cancer cases occur annually. Visual inspection the cervix following acetic acid application is practical but not reproducible or accurate. The objective this study was to develop a "deep learning"-based visual evaluation algorithm that automatically recognizes precancer/cancer.A population-based longitudinal cohort 9406 women ages 18-94 years...
(Abstracted from J Natl Cancer Inst 2019; doi: 10.1093/jnci/djy225) Ninety-nine percent of cervical cancers cases are caused by infections with a human papillomavirus (HPV). This cancer can be prevented in most women screening and HPV vaccination.
Hereditary tumor predisposition syndromes pose a challenge for early detection and timely treatment of tumors. In von Hippel-Lindau disease, desirable personalized surveillance programs are lacking due to insufficient data on genotype-specific risk profiles individual mutations. To describe neoplastic carriers pathogenic likely VHL germline mutations, our observational study recruited 1350 participants from 40 centers worldwide. 432 different mutations were observed, with p.Asn78Ser,...
Abstract Rationale: Langerhans cell histiocytosis (LCH) is characterized by clonal proliferation of immature dendritic cells, mainly affects children. LCH in adult sellar region extremely rare. In literature, optimal treatments remain unclear and only a few cases were treated using surgery. Here, we present rare case isolated hypothalamic-pituitary LHC female adult. We focused on elucidating the clinical manifestations immunohistochemical features LCH, exploring proper treatment adults....
Abstract Context Urinary bladder paraganglioma (UBPGL) is rare. Objective We aimed to characterize the presentation and outcomes of patients diagnosed with UBPGL. Methods conducted a multicenter study consecutive pathologically confirmed UBPGL evaluated between 1971 2021. Outcomes included repeat surgery, metastases, disease-specific mortality. Results Patients (n=110 total; n=56 [51%] women) were at median age 50 years (interquartile range [IQR], 36-61 years). Median tumor size was 2 cm...
Abstract Context Patients with adrenal hormone excess demonstrate increased cardiovascular (CV) risk and mortality. Objective We aimed to determine the effect of disorders on inflammation marker glycoprotein acetylation (GlycA), total branched-chain amino acids (BCAAs), ketone bodies, gut microbiome-derived metabolites trimethylamine N-oxide (TMAO) betaine. Methods conducted a single-center cross-sectional study patients nonfunctioning adenomas (NFAs), mild autonomous cortisol secretion...
Abstract Context Patients with nonfunctioning adenomas (NFAs), mild autonomous cortisol secretion (MACS) and Cushing syndrome (CS) demonstrate an increased cardiovascular risk. Objective This work aimed to determine the extent of lipoprotein abnormalities in NFA, MACS, CS. Methods We conducted a single-center, cross-sectional study patients NFA (n = 167), MACS 213), CS 142), referent individuals 202) between January 2015 July 2022. Triglyceride-rich particles (TRLP), low-density (LDLP),...
Guidelines suggest performing urine steroid profiling in patients with indeterminate adrenal tumors to make a noninvasive diagnosis of adrenocortical carcinoma (ACC). However, is not widely available.
To identify the presence of mouse beta-defensin 3 (Mbd3) (the human homologue 2) in different tissues and to define antimicrobial properties recombinant MBD3 (rMBD3) against a panel pathogens.Mbd3 gene expression before or after lipopolysaccharide (LPS) injection was compared by semi-quantitative RT-PCR. This analysis demonstrated that epithelial mucosal expressed Mbd3 independent LPS stimulation. Evaluation rMBD3 determined assessing median inhibition concentration (IC(50)), minimal...
Abstract Background Cushing’s syndrome has been described as a complex endocrine disorder characterized with high cortisol concentration. Correct and early diagnosis of is challenging. According to the latest guideline, bilateral inferior petrosal sinus sampling (BIPSS) considered be gold standard for differential diagnosis. However, in some unusual cases, this method may false positive. Here, we presented rare case orbital neuroendocrine tumor secreting adrenocorticotrophic hormone positive...
Objective Primary adrenal lymphoma (PAL) is easily misdiagnosed as other masses, such adrenocortical carcinoma and pheochromocytoma, but patients with PAL benefit little from surgery. The diagnostic method for thus far limited to biopsy. In our study, we aimed develop a quick efficient PAL. Methods Results At the same institution, 505 (between 2009 2019) 171 2019 2020) were separately included in primary validation studies. Univariate multivariate analyses conducted evaluate clinical...
Background and purposeTo develop validate a risk model (Extracranial Carotid Artery Stenosis score, ECAS score) to predict moderate severe ECAS. Furthermore, we compared discrimination of the score three existing models with regard both ECAS.MethodsThe was developed based on Renqiu Stroke Screening Study (RSSS), in which eligible patients were randomly divided into derivation (60%) validation (40%) cohorts. diagnosed by carotid duplex ultrasound according published criteria. Independent...
Objective The result interpretation of the captopril challenge test (CCT) for diagnosis primary aldosteronism (PA) is not standardized. Superiorities different indexes in CCT have been fully investigated. We aimed to comprehensively evaluate value and influence factors CCT-associated PA. Methods enrolled 312, 85, 179 97 patients groups PA, essential hypertension (EH), unilateral PA (UPA) bilateral (BPA), respectively. For each single index investigated, we computed diagnostic estimates...