A5030637072- Spinal Fractures and Fixation Techniques
- Spine and Intervertebral Disc Pathology
- Cervical and Thoracic Myelopathy
- Cancer, Hypoxia, and Metabolism
- Pelvic and Acetabular Injuries
- Head and Neck Surgical Oncology
- Spinal Hematomas and Complications
- Radiation Dose and Imaging
- Management of metastatic bone disease
- Medical Imaging and Analysis
- Neurosurgical Procedures and Complications
- Neuroblastoma Research and Treatments
- Glioma Diagnosis and Treatment
- Neurofibromatosis and Schwannoma Cases
- Traumatic Brain Injury and Neurovascular Disturbances
- Spinal Dysraphism and Malformations
- Adrenal and Paraganglionic Tumors
- Bone Tumor Diagnosis and Treatments
- Epilepsy research and treatment
- Musculoskeletal pain and rehabilitation
- Meningioma and schwannoma management
- Ocular Oncology and Treatments
- Scoliosis diagnosis and treatment
- Intracranial Aneurysms: Treatment and Complications
- Advanced Neuroimaging Techniques and Applications
University of Freiburg
2016-2025
University Medical Center Freiburg
2015-2025
National Institutes of Health
2015
Wellcome Trust
2015
Howard Hughes Medical Institute
2015
University of Basel
1953
Abstract Objectives Computed tomography (CT) is employed to evaluate surgical outcome after spinal interventions. Here, we investigate the potential of multispectral photon-counting computed (PC-CT) on image quality, diagnostic confidence, and radiation dose compared an energy-integrating CT (EID-CT). Methods In this prospective study, 32 patients underwent PC-CT spine. Data was reconstructed in two ways: (1) standard bone kernel with 65-keV (PC-CT std ) (2) 130-keV monoenergetic images 130...
Spontaneous intracranial hypotension (SIH) caused by a spinal CSF leak is multisymptom syndrome, which can dramatically affect physical and mental health. However, systematic data on health-related quality of life (HRQoL) health are scarce. We hypothesized that surgical treatment leads to significant sustained improvements in HRQoL patients with SIH.
Abstract Introduction Hemangioblastomas are rare, histologically benign, highly vascularized tumors of the brain, spinal cord, and retina, occurring sporadically or associated with autosomal dominant inherited von Hippel-Lindau (VHL) disease. Children adults VHL disease have one > 300 known germline mutations gene located on chromosome 3. They prone to develop hemangioblastomas, extremely rarely starting at age 6, 12–18, and, typically almost all, as adults. There is a plethora...
Spinal CSF leaks cause spontaneous intracranial hypotension (SIH). Surgical closure of spinal is the treatment choice for persisting leaks. approaches vary, and there are no studies in which minimally invasive techniques were used. In this study, authors aimed to detail safety feasibility microsurgical sealing using nonexpandable tubular retractors.
Purpose . To assess the frequency, risk factors, and management of accidental durotomy in minimally invasive transforaminal lumbar interbody fusion (MIS TLIF). Methods This single‐center study retrospectively investigates 372 patients who underwent MIS TLIF were mobilized within 24 hours after surgery. The frequency durotomies, intraoperative closure technique, body mass index, history previous surgery was recorded. Results We identified 32 durotomies 514 levels (6.2%). Analysis showed a...
The aim of the study was to investigate safety and efficacy minimally invasive tubular microdiscectomy for treatment recurrent lumbar disc herniation (LDH). As opposed endoscopic techniques, namely microendoscopic transforaminal discectomy, this microscopically assisted technique has never been used LDH.Thirty consecutive patients who underwent LDH were included in study. preoperative postoperative visual analog scale (VAS) scores pain, clinical outcome according modified Macnab criteria,...
Abstract Background/Aims Retinal haemangioblastomas (RH) remain a major cause of visual impairment in patients with von Hippel‐Lindau (VHL) disease. Identification genotype–phenotype correlation is an important prerequisite for better management, treatment and prognosis. Methods Retrospective, single‐centre cohort study 200 VHL patients. Genetic data date onset RH, central nervous system (CNSH), pheochromocytoma/paraganglioma (PPGL), clear cell renal carcinoma (ccRCC) pancreatic...
Abstract Design Prospective diagnostic study. Objectives Anatomical evaluation and graduation of the severity spinal stenosis is essential in degenerative cervical spine disease. In clinical practice, this subjectively categorized on MRI lacking an objective reliable classification. We implemented a fully-automated quantification canal compromise through 3D T2-weighted segmentation. Setting Medical Center - University Freiburg, Germany. Methods Evaluation 202 participants receiving spine....
Abstract Purpose Von Hippel-Lindau (VHL) disease is an autosomal-dominantly inherited tumor predisposition syndrome. One of the most common tumors are central nervous system (CNS) hemangioblastomas. Recommendations on initiation and continuation screening surveillance program for CNS in pediatric VHL patients based small case series thus low evidence level. To derive more robust recommendations, we report largest monocentric cohort patients. Methods We performed a retrospective analysis 99...
Purpose . To compare radiographic and clinical outcomes after anterior cervical discectomy in patients with degenerative disc disease using PEEK cages or PMMA spacers a minimum 1-year follow-up. Methods Anterior was performed 107 one two levels empty (51 levels), Sulcem (49 levels) Palacos (41 between January, 2005 February, 2009. Bony fusion, subsidence, sagittal alignment were retrospectively assessed CT scans radiographs at Clinical outcome measured the VAS, NDI, SF-36. Results fusion 65%...
Abstract Background Spinal hemangioblastomas (sHBs) are rare vascular tumors with significant neurological implications. Their management, particularly in von Hippel-Lindau (VHL) disease, remains challenging due to recurrence and functional decline. Timely identification intervention critical for optimal outcomes. Methods This international, multicenter retrospective cohort study included 357 patients (199 VHL-associated, 158 sporadic) from 13 neuro-oncological centers. Clinical imaging data...
Hereditary tumor predisposition syndromes pose a challenge for early detection and timely treatment of tumors. In von Hippel-Lindau disease, desirable personalized surveillance programs are lacking due to insufficient data on genotype-specific risk profiles individual mutations. To describe neoplastic carriers pathogenic likely VHL germline mutations, our observational study recruited 1350 participants from 40 centers worldwide. 432 different mutations were observed, with p.Asn78Ser,...
A radiation exposure study in vitro.This aimed to compare the of 2 different 3-dimensional (3D) C-arm devices on an anthropomorphic phantom.Minimally invasive pedicle screw placement requires intraoperative imaging techniques for visualization unexposed spine. Mobile 3D C-arms compose a image data set out multiple successive fluoroscopic images.We compared Siremobil Iso-C (Siemens Sector Healthcare, Erlangen, Germany) and Vision FD Vario (Ziehm Imaging, Nuremberg, regarding their exposure....
Retrospective case-control study.To compare the incidence, management, and outcome of incidental durotomy in revision microdiscectomy with open minimal-access surgery.Incidental occurs a variable incidence 3%-27% spine surgery. The highest rate microdiscectomy. intraoperative postoperative management dural tears varies literature definite impact on clinical has to be clarified.This is retrospective study medical records 135 patients who underwent microdiscectomy, divided into 2 subgroups:...
Hemangioblastomas are benign, highly vascularized tumors that can occur sporadically or as part of von Hippel-Lindau (VHL) disease. Traditionally, spinal hemangioblastomas have been surgically treated via an open approach. In recent years, however, minimally invasive techniques using tubular retractors increasingly applied in spine surgery. Such procedures involve less tissue trauma but also particularly demanding for the surgeon, especially cases vascular such hemangioblastomas. The object...
Randomized controlled trial.The aim of this study was to compare the dosemetrically determined radiation exposure surgeon and patient during minimally invasive transforaminal lumbar interbody fusion (MIS TLIF) using conventional 2D fluoroscopy (FLUORO) or 3D fluoroscopy-based navigation (NAV).MIS TLIF shown exhibit higher exposures compared open techniques. In particular, routinely exposed encounters risks increased doses. With additional use intraoperative navigation, major steps operation...
OBJECTIVE Presentation of a patient with acute subarachnoid hemorrhage from ruptured spinal artery aneurysm attributable to exacerbated Sjögren syndrome. CLINICAL PRESENTATION A 46-year-old woman symptoms syndrome experienced the onset extreme headache accompanied by nuchal rigidity. INTERVENTION computed tomographic scan revealed hemorrhage. Angiography showed an isolated branch right vertebral that was feeding anterior artery. Neither operative clipping nor endovascular coiling reasonable,...
In degenerative cervical myelopathy (DCM), focally increased spinal cord motion has been observed for C5/C6, but whether stenoses at other segments lead to similar pathodynamics and how severity of stenosis, age, gender affect them is still unclear. We report a prospective matched-pair controlled trial on 65 DCM patients. A high-resolution 3D T2 sampling perfection with application-optimized contrasts using different flip angle evolution (SPACE) phase-contrast magnetic resonance imaging...
To describe the minimally invasive technique for cement augmentation of cannulated and fenestrated screws using an injection cannula as well to report its safety efficacy.A total 157 pedicle had been cement-augmented during posterior screw-rod spondylodesis in 35 patients from January December 2012. Retrospective evaluation extravasation screw loosening was carried out postoperative plain radiographs thin-sliced triplanar computed tomography scans.Twenty-seven, largely prevertebral...