A5070069839- Thyroid Cancer Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Thyroid Disorders and Treatments
- Pituitary Gland Disorders and Treatments
- Adrenal and Paraganglionic Tumors
- Cancer, Hypoxia, and Metabolism
- Thyroid and Parathyroid Surgery
- Ion channel regulation and function
- Hormonal Regulation and Hypertension
- Neuroblastoma Research and Treatments
- BRCA gene mutations in cancer
- Diabetes Management and Education
- Advanced Glycation End Products research
- Lung Cancer Research Studies
- Cardiac electrophysiology and arrhythmias
- Cancer-related Molecular Pathways
- Head and Neck Anomalies
- Chronic Disease Management Strategies
- Cancer Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Medical Imaging Techniques and Applications
- Glioma Diagnosis and Treatment
- Growth Hormone and Insulin-like Growth Factors
- PI3K/AKT/mTOR signaling in cancer
- Adrenal Hormones and Disorders
University Medical Center Groningen
2016-2025
University of Groningen
2016-2025
LabCorp (United States)
2025
Dialyse Centrum Groningen
1993-2021
Wilhelmina Children's Hospital
2020
University Medical Center Utrecht
2005-2020
Jagiellonian University
2018
Martini Ziekenhuis
2004-2013
Radboud University Medical Center
2011-2012
OLVG
2011-2012
Thyroid disease and the metabolic syndrome are both associated with cardiovascular disease.The aim of this study was to explore hypothesis that thyroid function, in euthyroid subjects, is components syndrome, including serum lipid concentrations insulin resistance.A total 2703 adult inhabitants a middle-sized city The Netherlands participated cross-sectional study. Subjects who were not excluded, as subjects taking medication, medication for diabetes, whom data available (n = 1122)....
Tissue advanced glycation end products (AGE) are a measure of cumulative metabolic stress and trigger cytokines driven inflammatory reactions. AGE thought to contribute the chronic complications diabetes ESRD. autofluorescence is related accumulation AGE. Therefore, skin (AF) may provide prognostic information on mortality in hemodialysis (HD) patients. Skin AF was measured noninvasively with an reader at baseline 109 HD Overall cardiovascular monitored prospectively during period 3 yr. The...
Treatment with amiodarone is associated changes in thyroid function tests, but also dysfunction (amiodarone-induced hypothyroidism, AIH, and amiodarone-induced thyrotoxicosis, AIT). Both AIH AIT may develop apparently normal glands or the presence of underlying abnormalities. does not require withdrawal, treated levothyroxine replacement if overt, whereas subclinical forms be followed without treatment. Two main types are recognized: type 1 (AIT 1), a form iodine-induced hyperthyroidism...
At present, no European recommendations for the management of pediatric thyroid nodules and differentiated carcinoma (DTC) exist. Differences in clinical, molecular, pathological characteristics between adult DTC emphasize need specific population. An expert panel was instituted by executive committee Thyroid Association including an international community experts from a variety disciplines endocrinology, pathology, endocrine surgery, nuclear medicine, clinical genetics, oncology. The 2015...
Abstract Aims To provide one of the diagnostic categories for distal diabetic polyneuro‐pathy,several symptom scoring systems are available, which often extensive andlack in validation. We validated a new four‐item Diabetic Neuropathy Symptom (DNS) scorefor diagnosing polyneuropathy. Methods compared score characteristics generally accepted NeuropathySymptom Score (NSS) with DNS score, and tested construct validity,predictive value reproducibility Examinationscore, Semmes–Weinstein...
OBJECTIVE—Advanced glycation end products (AGEs) are biomarkers of metabolic stress and thought to contribute the increase coronary heart disease (CHD) in diabetes. Tissue autofluorescence is related accumulation AGEs. The aim present study was evaluate relationship between skin burden (hyperglycemia hyperlipidemia) its with CHD mortality. RESEARCH DESIGN AND METHODS—Skin measured noninvasively an reader 48 type 1 69 2 diabetic patients 43 control subjects. presence observed at baseline...
Advanced glycation end products (AGEs) are thought to have a role in the pathogenesis of diabetes complications. We recently reported association between skin autofluorescence, as measure tissue AGE accumulation, and diabetic neuropathy selected population. In this study, we investigated relation autofluorescence clinical variables including micro- macrovascular complications type 2 primary care population.Clinical data were obtained group (n = 973) control 231). Skin was assessed by...
Accumulation of advanced glycation end products (AGEs) is thought to play a role in the pathogenesis chronic complications diabetes mellitus and renal failure. Several studies indicate that AGE accumulation tissue may reflect cumulative effect hyperglycemia oxidative stress over many years. Simple quantitation could provide tool for assessing risk long-term complications. Because several AGEs exhibit autofluorescence, we developed noninvasive autofluorescence reader (AFR). Skin measured with...
Skin autofluorescence (AF) as measured with the AGE Reader (DiagnOptics Technologies, Groningen, The Netherlands) is a noninvasive prognostic marker in diabetes mellitus and other diseases increased cardiovascular risk. This study provides reference values of healthy Caucasian control subjects function age, tobacco smoking, gender.The results skin AF 428 by (n = 211) its nonautomated but otherwise similar predecessor, Autofluorescence 217), were analyzed. Linear regression analysis was...
The UK Prospective Diabetes Study (UKPDS) risk engine has become a standard for cardiovascular assessment in type 2 diabetes mellitus. Skin autofluorescence was recently introduced as an alternative tool diabetes. We investigated the prognostic value of skin events combination with UKPDS cohort patients managed primary care.Clinical, and data were obtained at baseline 2001-2002 group (n = 973). Follow-up concerning fatal non-fatal (primary endpoint) till 2005. Patients classified 'low risk'...
Purpose The primary aim was to study the risk of cardiovascular mortality in patients with differentiated thyroid carcinoma (DTC). Secondary aims were evaluate all-cause and explore relation between thyroid-stimulating hormone (TSH; also known as thyrotropin) level these outcome parameters. Patients Methods Subjects from two cohorts retrospectively compared by Cox regression analyses; 524 DTC 1,572 sex- age-matched controls a large population-based same geographic region. Results Mean age...
OBJECTIVE Depression is a common comorbidity of diabetes, undesirably affecting patients’ physical and mental functioning. Psychological interventions are effective treatments for depression in the general population as well patients with chronic disease. The aim this study was to assess efficacy individual mindfulness-based cognitive therapy (MBCT) behavior (CBT) comparison waiting-list control condition treating depressive symptoms adults type 1 or 2 diabetes. RESEARCH DESIGN AND METHODS...
Catecholamine excess is rare, but symptoms may be life threatening.The objective of the study was to investigate sensitivity 6-[F-18]fluoro-l-dihydroxyphenylalanine positron emission tomography ((18)F-DOPA PET), compared with (123)I-metaiodobenzylguanidine ((123)I-MIBG) scintigraphy and computer (CT)/magnetic resonance imaging (MRI) for tumor localization in patients catecholamine excess.All consecutive visiting University Medical Center Groningen, The Netherlands, between March 2003 January...
Multiple endocrine neoplasia type 2 is characterized by germline mutations in RET. For exon 10, comprehensive molecular and corresponding phenotypic data are scarce. The International RET Exon 10 Consortium, comprising 27 centers from 15 countries, analyzed patients with for clinical-risk profiles. Presentation, age-dependent penetrance, stage at presentation of medullary thyroid carcinoma (MTC), pheochromocytoma, hyperparathyroidism were studied. A total 340 subjects 103 families, age 4–86,...