A5000647055- Trypanosoma species research and implications
- Research on Leishmaniasis Studies
- Hormonal Regulation and Hypertension
- Adrenal and Paraganglionic Tumors
- Cancer, Hypoxia, and Metabolism
- Biotechnology and Related Fields
- Cardiac tumors and thrombi
- Insect behavior and control techniques
- Biochemical and Molecular Research
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Adenosine and Purinergic Signaling
- Insect Resistance and Genetics
- Insect symbiosis and bacterial influences
- Apelin-related biomedical research
- Pituitary Gland Disorders and Treatments
- Insect and Pesticide Research
- Plant and animal studies
- Viral Infectious Diseases and Gene Expression in Insects
- Epigenetics and DNA Methylation
- Turtle Biology and Conservation
- Global Health and Surgery
- Public Health in Brazil
- Developmental and Educational Neuropsychology
- Toxin Mechanisms and Immunotoxins
- Histone Deacetylase Inhibitors Research
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2023-2025
Universidade de São Paulo
2007-2024
National Council for Scientific and Technological Development
2021
Universidad de Los Andes
2021
Fundación Miguel Lillo
2009-2019
CSIRO Health and Biosecurity
2019
Universidad Católica de Cuenca
2018
Universidade Federal de Viçosa
2013-2014
Universidade de Ribeirão Preto
2007
Hospital Universitário de Santa Maria
2001
Abstract Intracellular parasites from the Leishmania genus cause Leishmaniasis, a disease affecting millions of people worldwide. NLRP3 inflammasome is key for outcome, but molecular mechanisms upstream activation are still unclear. Here, we demonstrate that despite absence pyroptosis, Gasdermin-D (GSDMD) active at early stages infection in macrophages, allowing transient cell permeabilization, potassium efflux, and activation. Further, GSDMD processed into non-canonical 25 kDa fragment....
Leishmaniasis is a worldwide public health problem caused by protozoan parasites of the genus Leishmania. Leishmania braziliensis most important species responsible for tegumentary leishmaniases in Brazil. An understanding molecular mechanisms underlying success this parasite urgently needed. in-depth study on modulation gene expression across life cycle stages L. covering coding and noncoding RNAs (ncRNAs) was missing presented herein. Analyses differentially expressed (DE) genes revealed...
Este texto analiza la evolución de las políticas públicas en Brasil dirigidas a enfrentar Enfermedades Crónicas No Transmisibles (ECNT), como hipertensión, diabetes, obesidad, enfermedades cardiovasculares y cáncer. El análisis destaca los avances logrados, desafíos persistentes el impacto estas salud población. estudio, desarrollado con un enfoque narrativo cualitativo, se centra públicas, marcos regulatorios planes estratégicos, Plan Acción Estratégico para Enfrentamiento ECNT (2021-2030)....
In this study, our aim was to search for new genotype-phenotype correlations in patients with Von Hippel-Lindau (VHL) disease. We retrospectively studied 53 consecutive VHL disease and confirmed genetic diagnoses from 32 relatives. Most pathogenic or likely variants were missense (18 out of 32; 56.25%). The median size the large carcinoma (RCC) 3.6 cm (interquartile range, 2.8 6.5 cm). Interestingly, RCC harboring (n = 9) significantly greater than that 7) (5.4 [3.65 6.6] vs. 2.9 [2.45...
Hereditary tumor predisposition syndromes pose a challenge for early detection and timely treatment of tumors. In von Hippel-Lindau disease, desirable personalized surveillance programs are lacking due to insufficient data on genotype-specific risk profiles individual mutations. To describe neoplastic carriers pathogenic likely VHL germline mutations, our observational study recruited 1350 participants from 40 centers worldwide. 432 different mutations were observed, with p.Asn78Ser,...
Carney-Stratakis syndrome (CSS), a rare condition characterized by paragangliomas and/or pheochromocytomas and gastrointestinal stromal tumors (GIST), is caused germline heterozygous pathogenic variants in the succinate dehydrogenase subunit genes (SDHB, SDHC, SDHD). Histological, genetic, functional analyses were conducted 59-year-old female with CSS (9 cm left pheochromocytoma, 4.8 paraganglioma, 9.3 GIST). Whole-exome sequencing (WES) of DNA paired tumor was performed. WES identified...
El aumento paulatino de la presencia estudiantes diagnosticados Trastornos del Espectro Autista (TEA) en las aulas Educación Infantil, exige realización investigaciones que permitan describir, identificar y evaluar los procesos enseñanza aprendizaje un aula ordinaria a asiste alumnado con condición autista. En este contexto, surge una investigación cuyos resultados se presentan artículo. Sus objetivos son describir analizar voz profesorado familias sobre experiencia convivencia...
Background Visceral leishmaniasis is an important tropical disease, and Leishmania infantum chagasi (synonym of infantum) the main pathogenic agent visceral in New World. Recently, ecto-nucleoside triphosphate diphosphohydrolases (E-NTPDases) were identified as enablers infection virulence factors many pathogens. Two putative E-NTPDases (∼70 kDa ∼45 kDa) have been found L. genome. Here, we studied E-NTPDase from to describe its natural occurrence, biochemical characteristics influence on...
Previous work has suggested that Trypanosoma cruzi diphosphohydrolase 1 (TcNTPDase-1) may be involved in the infection of mammalian cells and serve as a potential target for rational drug design. In this work, we produced recombinant TcNTPDase-1 evaluated its nucleotidase activity, cellular localization role parasite adhesion to host cells. was able utilize broad range triphosphate diphosphate nucleosides. The enzyme's Km ATP (0.096 mM) capability influence host's ATP-dependent purinergic...
Abstract Background The interaction between gut bacterial symbionts and Tephritidae became the focus of several studies that showed bacteria contributed to nutritional status reproductive potential its fruit fly hosts. Anastrepha fraterculus is an economically important pest in South America. This currently controlled by insecticides, which prompt development environmentally friendly methods such as sterile insect technique (SIT). For SIT be effective, a deep understanding biology sexual...
Abstract Anastrepha fraterculus (Wiedemann), a pest of great economic importance in South America, needs urgently to be controlled by environmentally friendly methods such as the sterile insect technique for which mass rearing insects is required. Because oogenesis takes place during adult stage, mass-rearing facilities should provide females diet that maximizes egg production at lowest cost. Accordingly, we investigated effect artificial protein sources (yeast derivatives different cost but...
Abstract Context Limited information is available concerning the genetic spectrum of pheochromocytoma and paraganglioma (PPGL) patients in South America. Germline SDHB large deletions are very rare worldwide, but most individuals harboring exon 1 deletion originated from Iberian Peninsula. Objective Our aim was to investigate defects a cohort Brazilian with PPGLs. Methods Genetic investigation 155 index PPGL performed by Sanger DNA sequencing, multiplex ligation-dependent probe...
Confirmatory tests represent a fundamental step in primary aldosteronism (PA) diagnosis, but they are laborious and often require hospital environment due to the risks involved.
In the protozoan parasite Leishmania , most genes encoding for ribosomal proteins (RPs) are present as two or more copies in genome. However, their untranslated regions (UTRs) predominantly divergent and might be associated with a distinct regulation of expression paralogous genes. Herein, we investigated profiles RPs (S16 L13a) encoded by duplicated major . The S16 protein possess identical coding sequences (CDSs) UTRs, whereas CDSs L13a diverge amino acids UTRs. Using CRISPR/Cas9 genome...
Germline and somatic drivers are identified in 30% 40% of pheochromocytomas paragangliomas (PPGLs), respectively. In this study, we investigated the genetic landscape PPGLs a Brazilian cohort.
Host manipulation is a common strategy for invading pathogens. Trypanosoma cruzi, the causative agent of Chagas Disease, lives intracellularly within host cells. During infection, parasite-associated modifications occur to cell metabolism and morphology. However, little known about effect T. cruzi infection on nucleus nuclear functionality. Here, we show that can modulate transcription splicing machinery in non-professional phagocytic cells during infection. We found regulates RNA polymerase...
Senecio nutans Sch. Bip., S. viridis var. Phill. and spegazzinii Cabrera are native species used in traditional medicine of northwestern Argentina. The total phenolics, flavonoids caffeoylquinic acids contents, as well radical scavenging, antioxidant, hemolytic cytotoxic activities aqueous extracts (infusion decoction) all three were determined. was the most active. did not show antibacterial activity. Alkaloids detected any studied species.
BACKGROUND: Expression dysregulation of HOX homeobox genes has been observed in several cancers, including head and neck squamous cell carcinoma (HNSC). Although characterization gene roles HNSC development reported, there is still a need to better understand their real contribution tumorigenesis. OBJECTIVE: The present study aimed evaluate the protein-coding ( HOXA10, HOXC9, HOXC10, HOXC13) cellular processes related carcinogenesis progression HNSC. METHODS: was analyzed RNA-Seq data from...
Abstract Background Aldosterone excess chronically induces oxidative stress and cell proliferation. Previously, a single study investigated primary aldosteronism (PA) in patients with papillary thyroid cancer (PTC), albeit without matched control group. Methods We conducted propensity score case-control to investigate the association between PA PTC individuals arterial hypertension (HT). was 137 HT. The group included (1:1) age, sex-, body mass index (BMI)-matched secondary analysis which...
Abstract Disclosure: L.S. Santana: None. A.G. Guimaraes: F. Freitas-Castro: A.W. Maciel: G.F. Fagundes: M.A. Pereira: L.F. Drager: L.A. Bortolotto: M.C. Fragoso: B.B. Mendonca: A. Latronico: M.Q. Almeida: Primary aldosteronism (PA) is the most common cause of endocrine hypertension, with an estimated prevalence 10-20% in patients referred to tertiary hospitals. The causes PA are bilateral adrenal hyperplasia (BAH) and aldosteronomas. Significant advances elucidating pathogenesis have been...